{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:10:53Z","timestamp":1760775053788,"version":"build-2065373602"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.bmcl.2023.129490","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:30:45Z","timestamp":1695763845000},"page":"129490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents"],"prefix":"10.1016","volume":"95","author":[{"given":"Ling-Jie","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"De Jonghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Waer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"Herdewijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129490_b0005","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1021\/cr900021w","article-title":"IMP dehydrogenase: structure, mechanism and inhibition","volume":"109","author":"Hedstrom","year":"2009","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2023.129490_b0010","doi-asserted-by":"crossref","first-page":"e4399","DOI":"10.1002\/pro.4399","article-title":"The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases","volume":"31","author":"Buey","year":"2022","journal-title":"Protein Sci"},{"key":"10.1016\/j.bmcl.2023.129490_b0015","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3390\/microorganisms10081631","article-title":"Inhibitors of nucleotide biosynthesis as candidates for a wide spectrum of antiviral chemotherapy","volume":"10","author":"Sep\u00falveda","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.bmcl.2023.129490_b0020","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3390\/cancers11091346","article-title":"Anti-tumor potential of IMP dehydrogenase inhibitors: A century-long story","volume":"11","author":"Naffouje","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bmcl.2023.129490_b0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4155\/fmc.09.147","article-title":"Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics","volume":"2","author":"Braun-Sand","year":"2010","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmcl.2023.129490_b0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/13543776.2017.1280463","article-title":"Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002\u20132016)","volume":"27","author":"Cuny","year":"2017","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmcl.2023.129490_b0035","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/0929867043455648","article-title":"Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH) - the major therapeutic target","volume":"11","author":"Pankiewicz","year":"2004","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmcl.2023.129490_b0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/095632020701800501","article-title":"Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery","volume":"18","author":"Nair","year":"2007","journal-title":"Antivir Chem Chemother"},{"key":"10.1016\/j.bmcl.2023.129490_b0045","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/681482","article-title":"Mizoribine: A new approach in the treatment of renal disease","volume":"2009","author":"Kawasaki","year":"2009","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.bmcl.2023.129490_b0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s10593-021-02912-8","article-title":"Antiviral nucleoside analogs","volume":"57","author":"Kataev","year":"2021","journal-title":"Chem Heterocycl Compd"},{"key":"10.1016\/j.bmcl.2023.129490_b0055","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2174\/0929867329666220909122820","article-title":"Prodrugs of nucleoside 5'-monophosphate analogues: overview of the recent literature concerning their synthesis and applications","volume":"30","author":"Roy","year":"2023","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmcl.2023.129490_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2040206618775243","article-title":"Phosphoramidates and phosphonamidates (ProTides) with antiviral activity","volume":"26","author":"Slusarczyk","year":"2018","journal-title":"Antivir Chem Chemother"},{"key":"10.1016\/j.bmcl.2023.129490_b0065","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/1389557517666170216151601","article-title":"Amino acid ester prodrugs of nucleoside and nucleotide antivirals","volume":"17","author":"Krecmerova","year":"2017","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.bmcl.2023.129490_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2016.06.002","article-title":"Towards antiviral therapies for treating dengue virus infections","volume":"30","author":"Kaptein","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.bmcl.2023.129490_b0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fimmu.2022.855496","article-title":"Molnupiravir and its antiviral activity against COVID-19","volume":"13","author":"Tian","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.bmcl.2023.129490_b0080","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1039\/b005510g","article-title":"Synthesis of sugar-modified analogs of bredinin (mizoribine), a clinically useful immunosuppressant, by a novel photochemical imidazole ring-cleavage reaction as the key step","volume":"1","author":"Shuto","year":"2000","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1016\/j.bmcl.2023.129490_b0085","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1039\/C5OB00427F","article-title":"Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication","volume":"13","author":"Maiti","year":"2015","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmcl.2023.129490_b0090","doi-asserted-by":"crossref","first-page":"e20191247","DOI":"10.1084\/jem.20191247","article-title":"Effects of interleukin-2 in immunostimulation and immunosuppression","volume":"217","author":"Pol","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.bmcl.2023.129490_b0095","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00007691-200108000-00006","article-title":"Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells","volume":"23","author":"Ahmed","year":"2001","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.bmcl.2023.129490_b0100","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/TP.0b013e3181613f0c","article-title":"Occurrence of autoimmunity after xenothymus transplantation in T-cell-deficient mice depends on the thymus transplant technique","volume":"85","author":"Devos","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.bmcl.2023.129490_b0105","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1056\/NEJMra033540","article-title":"Immunosuppressive drugs for kidney transplantation","volume":"351","author":"Halloran","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23003682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23003682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:49:20Z","timestamp":1760773760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23003682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":21,"alternative-id":["S0960894X23003682"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129490","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129490"}}