{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:29:14Z","timestamp":1778563754203,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019688","name":"Department of Medicine, Georgetown University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["EKFS2013 A213"],"award-info":[{"award-number":["EKFS2013 A213"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bmcl.2023.129501","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:41:49Z","timestamp":1696509709000},"page":"129501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism"],"prefix":"10.1016","volume":"96","author":[{"given":"Philipp","family":"Maier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2060-4851","authenticated-orcid":false,"given":"Britta","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Gabor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samario","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-8986","authenticated-orcid":false,"given":"Stefanie","family":"Hahner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3085-7561","authenticated-orcid":false,"given":"Andreas","family":"Schirbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129501_b0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nrendo.2011.223","article-title":"Primary aldosteronism in 2011: Towards a better understanding of causation and consequences","volume":"8","author":"Stowasser","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.bmcl.2023.129501_b0010","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1210\/jc.2008-2116","article-title":"Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German Conn\u2019s Registry","volume":"94","author":"Born-Frontsberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2023.129501_b0015","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1210\/jc.2015-3405","article-title":"Prevalence of malignancies in patients with primary aldosteronism","volume":"101","author":"Lang","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2023.129501_b0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12020-016-0983-9","article-title":"Worsening of lipid metabolism after successful treatment of primary aldosteronism","volume":"54","author":"Adolf","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.bmcl.2023.129501_b0025","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: An endocrine society clinical practice guideline","volume":"101","author":"Funder JW","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2023.129501_b0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/0003-4819-151-5-200909010-00007","article-title":"Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism","volume":"151","author":"Kempers","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bmcl.2023.129501_b0035","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/HYPERTENSIONAHA.110.168484","article-title":"Adrenal venous sampling: evaluation of the German Conn's registry","volume":"57","author":"Vonend","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.bmcl.2023.129501_b0040","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2265.2009.03714.x","article-title":"Adrenal vein sampling for Primary Aldosteronism: time for a reality check","volume":"72","author":"Stewart","year":"2010","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.bmcl.2023.129501_b0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/EJE-18-0328","article-title":"Radiation exposure of adrenal vein sampling: a German Multicenter Study","volume":"179","author":"Fuss","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bmcl.2023.129501_b0050","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1055\/a-1535-2566","article-title":"Reduction of radiation exposure in adrenal vein sampling: impact of the rapid cortisol assay","volume":"193","author":"Augustin","year":"2021","journal-title":"Fortschr R\u00f6ntgenstr"},{"key":"10.1016\/j.bmcl.2023.129501_b0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0971-6203.25665","article-title":"Positron emission tomography: An overview","volume":"31","author":"Shukla","year":"2006","journal-title":"J Med Phys"},{"key":"10.1016\/j.bmcl.2023.129501_b0060","doi-asserted-by":"crossref","first-page":"20961","DOI":"10.1016\/S0021-9258(19)30030-4","article-title":"Characterization of 2 Genes encoding human steroid 11-beta-hydroxylase (P-45011-Beta)","volume":"264","author":"Mornet","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/ml100071j","article-title":"First Selective CYP11B1 inhibitors for the treatment of cortisol-dependent diseases","volume":"2","author":"Hille","year":"2011","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129501_b0070","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1530\/EJE-20-0532","article-title":"Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism","volume":"183","author":"Soinio","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bmcl.2023.129501_b0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41591-022-02114-5","article-title":"[11C]metomidate PET-CT versus adrenal vein sampling for diagnosis surgically curable primary aldosteronism: a prospective, within-patient trial","volume":"29","author":"Wu","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.bmcl.2023.129501_b0080","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1210\/jc.2015-3431","article-title":"A Novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism","volume":"101","author":"Abe","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2023.129501_b0085","doi-asserted-by":"crossref","first-page":"9321","DOI":"10.1021\/acs.jmedchem.1c00539","article-title":"Development of [18F]aldoview as the first highly selective aldosterone synthase PET tracer for imaging of primary hyperaldosteronism","volume":"64","author":"Sander","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0090","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1021\/acs.jmedchem.5b00407","article-title":"Structure-activity relationships, pharmacokinetics, and in vivo activity of CYP11B2 and CYP11B1 inhibitors","volume":"58","author":"Papillon","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105332","article-title":"Aldosterone synthase inhibitors for cardiovascular diseases: A comprehensive review of preclinical, clinical and in silico data","volume":"163","author":"Lenzini","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bmcl.2023.129501_b0100","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/ml400324c","article-title":"Discovery and in vivo evaluation of potent dual CYP11B2 (aldosterone synthase) and CYP11B1 inhibitors","volume":"4","author":"Meredith","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129501_b0105","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1021\/acs.jmedchem.8b00328","article-title":"Discovery of novel pyrazole-based selective aldosterone synthase (CYP11B2) inhibitors: A new template to coordinate the heme-iron motif of CYP11B2","volume":"61","author":"Sakakibara","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0110","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/CIRCULATIONAHA.111.029892","article-title":"Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial","volume":"124","author":"Calhoun","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bmcl.2023.129501_b0115","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jc.2013-2117","article-title":"LCI699, a potent 11beta-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing's disease: results from a multicenter, proof-of-concept study","volume":"99","author":"Bertagna","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2023.129501_b0120","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acsmedchemlett.9b00152","article-title":"Development of highly selective pyrimidine-based aldosterone synthase (CYP11B2) inhibitors","volume":"10","author":"Sparks","year":"2019","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129501_b0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/acsmedchemlett.6b00455","article-title":"Discovery of spirocyclic aldosterone synthase inhibitors as potential treatments for resistant hypertension","volume":"8","author":"Petrilli","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129501_b0130","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1021\/jm101470k","article-title":"Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]-quinolin-4-one derivatives","volume":"54","author":"Lucas","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0135","unstructured":"Chamoin S, Hu Q-Y, Papillon J. Aryl Pyridine as Aldosterone Synthase Inhibitors. WO2010130796A1."},{"key":"10.1016\/j.bmcl.2023.129501_b0140","unstructured":"Allolio B, Hahner S, Schirbel A, Hartmann R, Zimmer C. PET Radiopharmaceuticals for the Differential Diagnosis Between Bilateral and Unilateral Conditions of Primary Hyperaldosteronism. WO2011151411A1."},{"key":"10.1016\/j.bmcl.2023.129501_b0145","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1002\/anie.200802174","article-title":"Asymmetric suzuki-miyaura coupling reactions catalyzed by chiral palladium nanoparticles at room temperature","volume":"47","author":"Sawai","year":"2008","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmcl.2023.129501_b0150","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0040-4039(99)02204-2","article-title":"Synthesis of the 4-arylindole portion of the antitumor agent diazoamide and related studies","volume":"41","author":"Chan","year":"2000","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmcl.2023.129501_b0155","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1016\/S0040-4020(00)00928-5","article-title":"Suzuki cross-coupling reaction of sterically hindered aryl boronates with 3-iodo-4-methoxybenzoic acid methylester","volume":"56","author":"Chaumeil","year":"2000","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2023.129501_b0160","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1021\/jm0503704","article-title":"Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis","volume":"48","author":"Voets","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0165","unstructured":"Hu QY, Papillon J. Benzoxazolone Derivatives as Aldosterone Synthase Inhibitors. WO2010130773A2."},{"key":"10.1016\/j.bmcl.2023.129501_b0170","doi-asserted-by":"crossref","first-page":"10380","DOI":"10.1002\/chem.200901617","article-title":"Detection and identification of alkylating agents by using a bioinspired \u201cChemical Nose\u201d","volume":"15","author":"Hertzog-Ronen","year":"2009","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmcl.2023.129501_b0175","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1039\/C4TC01474J","article-title":"New sulfone-based electron-transport materials with high triplet energy for highly efficient blue phosphorescent organic light-emitting diodes","volume":"2","author":"Jeon","year":"2014","journal-title":"J Mater Chem C"},{"key":"10.1016\/j.bmcl.2023.129501_b0180","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1021\/jm00010a005","article-title":"Novel approach to dual-acting thromboxane receptor antagonist\/synthase inhibitors based on the link of 1,3-dioxane-thromboxane receptor antagonists and -thromboxane synthase inhibitors","volume":"38","author":"Ackerley","year":"1995","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0185","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1021\/jo00439a002","article-title":"A General One-Step Synthesis of Nitriles from Ketones Using Tosylmethyl Isocyanide. Introduction of a One-Carbon Unit","volume":"42","author":"Oldenziel","year":"1977","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejmech.2015.04.013","article-title":"Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11b-hydroxylase","volume":"96","author":"Hu","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0195","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1248\/cpb.47.1685","article-title":"Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb\/IIIa Antagonists. 1. The selection of naphthalene derivatives","volume":"67","author":"Ono","year":"1999","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2023.129501_b0200","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/jm00080a014","article-title":"Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives","volume":"35","author":"Street","year":"1992","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129501_b0205","unstructured":"Buckman B, Serebryany V, Nicholas JB, Seiwert S. Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication. WO2012054874A1."},{"key":"10.1016\/j.bmcl.2023.129501_b0210","unstructured":"Beswick PJ, Harling JD, Kleanthous S, Patel VK, Simpson J. Propionic acid derivatives and their use as hppars activators. WO2004000762A2."},{"key":"10.1016\/j.bmcl.2023.129501_b0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ab.2009.07.025","article-title":"Coexpression of CYP11B2 and CYP11B1 with adrenotoxin and adrenotoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors","volume":"394","author":"LaSala","year":"2009","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bmcl.2023.129501_b0220","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0303-7207(94)90277-1","article-title":"The NCI-H295 cell line: a pluripotent model for human adrenocortical studies","volume":"100","author":"Rainey","year":"1994","journal-title":"Mol Cell Endocrinol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23003797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23003797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:48:28Z","timestamp":1760773708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23003797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":44,"alternative-id":["S0960894X23003797"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129501","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"129501"}}