{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:41Z","timestamp":1790713421242,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bmcl.2023.129541","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T13:44:54Z","timestamp":1699623894000},"page":"129541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation"],"prefix":"10.1016","volume":"97","author":[{"given":"Rie","family":"Nishikawa-Shimono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-7799","authenticated-orcid":false,"given":"Masafumi","family":"Kamitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Futamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamaguchi-Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yabuuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitose","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Tanaka-Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Satake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Abe-Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Funayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koga","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Uozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunoshin","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Nakamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemi","family":"Mishima-Tsumagari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudai","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Asami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129541_b0005","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1021\/acs.jmedchem.0c00352","article-title":"Matrix metalloproteinases as new targets in Alzheimer's disease: opportunities and challenges","volume":"63","author":"Zipfel","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129541_b0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/path.1400","article-title":"Extracellular matrix remodelling: the role of matrix metalloproteinases","volume":"200","author":"Stamenkovic","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.bmcl.2023.129541_b0015","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bmcl.2023.129541_b0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.00047-08","article-title":"Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock","volume":"22","author":"Vanlaere","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmcl.2023.129541_b0025","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","article-title":"Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage","volume":"97","author":"Mitchell","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bmcl.2023.129541_b0030","doi-asserted-by":"crossref","first-page":"27757","DOI":"10.1038\/srep27757","article-title":"Transient ECM protease activity promotes synaptic plasticity","volume":"6","author":"Magnowska","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2023.129541_b0035","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.celrep.2014.10.064","article-title":"Pharmacogenetic inhibition of eIF4E-dependent MMP-9 mRNA translation reverses fragile X syndrome-like phenotypes","volume":"9","author":"Gkogkas","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmcl.2023.129541_b0040","doi-asserted-by":"crossref","first-page":"9867","DOI":"10.1523\/JNEUROSCI.1162-14.2014","article-title":"Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model","volume":"34","author":"Sidhu","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmcl.2023.129541_b0045","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/ajmg.a.36023","article-title":"High MMP-9 activity levels in fragile X syndrome are lowered by minocycline","volume":"161","author":"Dziembowska","year":"2013","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.bmcl.2023.129541_b0050","doi-asserted-by":"crossref","first-page":"e49475","DOI":"10.1371\/journal.pone.0049475","article-title":"Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders","volume":"7","author":"Kong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2023.129541_b0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13229-016-0110-z","article-title":"Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders","volume":"7","author":"Fiorentino","year":"2016","journal-title":"Mol Autism"},{"key":"10.1016\/j.bmcl.2023.129541_b0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model","volume":"46","author":"Bilousova","year":"2009","journal-title":"J Med Genet"},{"key":"10.1016\/j.bmcl.2023.129541_b0065","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/cr9804543","article-title":"Design and therapeutic application of matrix metalloproteinase inhibitors","volume":"99","author":"Whittaker","year":"1999","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2023.129541_b0070","first-page":"2087","article-title":"A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts","volume":"53","author":"Davies","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2023.129541_b0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/jm970494j","article-title":"Matrix metalloproteinase inhibitors: a structure-activity study","volume":"41","author":"Levy","year":"1998","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129541_b0080","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.4049\/jimmunol.154.9.4379","article-title":"T cell gelatinases mediate basement membrane transmigration in vitro","volume":"154","author":"Leppert","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.bmcl.2023.129541_b0085","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/sj.bjc.6603043","article-title":"Towards third generation matrix metalloproteinase inhibitors for cancer therapy","volume":"94","author":"Overall","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bmcl.2023.129541_b0090","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1074\/jbc.M117.806075","article-title":"Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation","volume":"292","author":"Scannevin","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2023.129541_b0095","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/acschemneuro.6b00029","article-title":"Central nervous system multiparameter optimization desirability: application in drug discovery","volume":"7","author":"Wager","year":"2016","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.bmcl.2023.129541_b0100","unstructured":"Molecular Operating Environment (MOE), 2022.02 Chemical Computing Group ULC, 910-1010 Sher-Brooke St. W., Montreal, QC H3A 2R7, Canada, 2023."},{"key":"10.1016\/j.bmcl.2023.129541_b0105","doi-asserted-by":"crossref","first-page":"14472","DOI":"10.1021\/acs.joc.8b02180","article-title":"Carboxylic acid-promoted single-step indole construction from simple anilines and ketones via aerobic cross-dehydrogenative coupling","volume":"83","author":"Ren","year":"2018","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2023.129541_b0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.biochi.2004.11.019","article-title":"Crystal structures of MMPs in complex with physiological and pharmacological inhibitors","volume":"87","author":"Maskos","year":"2005","journal-title":"Biochimie"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:49:55Z","timestamp":1760773795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23004195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":22,"alternative-id":["S0960894X23004195"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129541","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129541"}}