{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:08:00Z","timestamp":1778792880273,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["108.05-2017.311"],"award-info":[{"award-number":["108.05-2017.311"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["108"],"award-info":[{"award-number":["108"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bmcl.2023.129574","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T18:38:30Z","timestamp":1701628710000},"page":"129574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Design, synthesis, biological evaluation and molecular docking of alkoxyaurones as potent pancreatic lipase inhibitors"],"prefix":"10.1016","volume":"98","author":[{"given":"Cam-Van","family":"Thi Vo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang","family":"Thanh Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien","family":"Ngoc Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manh","family":"Quoc Dao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vy","family":"Thao Vo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oanh","family":"Thi Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loc","family":"Thanh Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh-Dao","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129574_b0005","unstructured":"WHO. Obesity and overweight. Accessed May 27, 2023. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"10.1016\/j.bmcl.2023.129574_b0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"Bl\u00fcher","year":"2019","journal-title":"Nat Rev Endocrinol."},{"key":"10.1016\/j.bmcl.2023.129574_b0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41573-021-00337-8","article-title":"Anti-obesity drug discovery: advances and challenges","volume":"21","author":"M\u00fcller","year":"2022","journal-title":"Nat Rev Drug Discov."},{"key":"10.1016\/j.bmcl.2023.129574_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110314","article-title":"Lipase inhibitors for obesity: A review","volume":"128","author":"Liu","year":"2020","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.bmcl.2023.129574_b0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-2999(02)01422-X","article-title":"Orlistat: its current status as an anti-obesity drug","volume":"440","author":"Ballinger","year":"2002","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.bmcl.2023.129574_b0030","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/clpt.1994.104","article-title":"Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers","volume":"56","author":"Zhi","year":"1994","journal-title":"Clin Pharmacol Therapeut."},{"key":"10.1016\/j.bmcl.2023.129574_b0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1592\/phco.20.4.270.34882","article-title":"Orlistat, a new lipase inhibitor for the management of obesity","volume":"20","author":"Heck","year":"2000","journal-title":"Pharmacotherapy."},{"key":"10.1016\/j.bmcl.2023.129574_b0040","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1517\/17460441.2013.792804","article-title":"New advances in models and strategies for developing anti-obesity drugs","volume":"8","author":"Kim","year":"2013","journal-title":"Expert Opin Drug Discov."},{"key":"10.1016\/j.bmcl.2023.129574_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104681","article-title":"Targeting obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review","volume":"155","author":"Rajan","year":"2020","journal-title":"Pharmacol Res."},{"key":"10.1016\/j.bmcl.2023.129574_b0050","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/973143","article-title":"Medicinal plants and their inhibitory activities against pancreatic lipase: a review","volume":"2015","author":"Seyedan","year":"2015","journal-title":"Evidence-Based Complementary Alternative Med."},{"key":"10.1016\/j.bmcl.2023.129574_b0055","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.phytochem.2010.07.011","article-title":"Possible anti-obesity therapeutics from nature\u2013A review","volume":"71","author":"Yun","year":"2010","journal-title":"Phytochemistry."},{"key":"10.1016\/j.bmcl.2023.129574_b0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.phytol.2022.06.011","article-title":"Natural mimetic 4-benzyloxychalcones as potent pancreatic lipase inhibitors: Virtual screening, synthesis and biological evaluation","volume":"51","author":"Vo","year":"2022","journal-title":"Phytochem Lett."},{"key":"10.1016\/j.bmcl.2023.129574_b0065","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1055\/s-0035-1546173","article-title":"Polyphenolic compounds as pancreatic lipase inhibitors","volume":"81","author":"Buchholz","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.bmcl.2023.129574_b0070","doi-asserted-by":"crossref","unstructured":"Sui G, Li T, Zhang B, Wang R, Hao H, Zhou W. Recent advances on synthesis and biological activities of aurones. Bioorg Med Chem. Jan 1 2021;29:115895. 10.1016\/j.bmc.2020.115895.","DOI":"10.1016\/j.bmc.2020.115895"},{"key":"10.1016\/j.bmcl.2023.129574_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25204657","article-title":"Exploring Aurone Derivatives as Potential Human Pancreatic Lipase Inhibitors through Molecular Docking and Molecular Dynamics Simulations","author":"Nguyen","year":"202025204657","journal-title":"Molecules."},{"key":"10.1016\/j.bmcl.2023.129574_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106805","article-title":"Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies","volume":"140","author":"Saroha","year":"2023","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bmcl.2023.129574_b0085","first-page":"29262","article-title":"FDA-Approved Pharmacotherapy for Weight Loss Over the Last Decade","volume":"14","author":"Idrees","year":"2022","journal-title":"Cureus."},{"key":"10.1016\/j.bmcl.2023.129574_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2021.101248","article-title":"Quercetin is a promising pancreatic lipase inhibitor in reducing fat absorption in vivo","volume":"43","author":"Zhou","year":"2021","journal-title":"Food Biosci."},{"key":"10.1016\/j.bmcl.2023.129574_b0095","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1016\/j.bmcl.2017.06.040","article-title":"Synthesis of 6-hydroxyaurone analogues and evaluation of their \u03b1-glucosidase inhibitory and glucose consumption-promoting activity: development of highly active 5, 6-disubstituted derivatives","volume":"27","author":"Sun","year":"2017","journal-title":"Bioorg Med Chem Lett."},{"key":"10.1016\/j.bmcl.2023.129574_b0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1515\/HC.2007.13.1.43","article-title":"PTSA catalyzed Claisen-Schmidt condensation in solvent-free conditions under microwave irradiation","volume":"13","author":"Mogilaiah","year":"2007","journal-title":"Heterocycl Commun."},{"key":"10.1016\/j.bmcl.2023.129574_b0105","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2478\/s11696-013-0359-z","article-title":"KI-catalysed synthesis of 4-methylcatechol dimethylacetate and fragrant compound Calone 1951\u00ae","volume":"67","author":"Zhang","year":"2013","journal-title":"Chem Pap."},{"key":"10.1016\/j.bmcl.2023.129574_b0110","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3987\/COM-01-9182","article-title":"An efficient synthesis of 4, 6-dimethoxyaurones","volume":"55","author":"Beney","year":"2001","journal-title":"Heterocycles."},{"key":"10.1016\/j.bmcl.2023.129574_b0115","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1021\/ja01878a018","article-title":"Derivatives of Coumaran. V. Synthesis of 4-Hydroxycoumaran-3-one","volume":"61","author":"Shriner","year":"1939","journal-title":"J Am Chem Soc."},{"key":"10.1016\/j.bmcl.2023.129574_b0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1248\/cpb.49.105","article-title":"Two new aurones from marine brown alga Spatoglossum variabile","volume":"49","author":"Choudhary","year":"2001","journal-title":"Chem Pharmaceut Bull."},{"key":"10.1016\/j.bmcl.2023.129574_b0125","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1007\/s00044-015-1400-2","article-title":"Synthesis and structural elucidation of two new series of aurone derivatives as potent inhibitors against the proliferation of human cancer cells","volume":"24","author":"Elhadi","year":"2015","journal-title":"Med Chem Res."},{"key":"10.1016\/j.bmcl.2023.129574_b0130","first-page":"28","article-title":"The infrared spectroscopy of Alkenes","volume":"11","author":"Smith","year":"2016","journal-title":"Spectroscopy."},{"key":"10.1016\/j.bmcl.2023.129574_b0135","doi-asserted-by":"crossref","first-page":"1000103","DOI":"10.4172\/2167-065X.1000103","article-title":"Direct measurement of lipase inhibition by orlistat using a dissolution linked in vitro assay","volume":"1","author":"Lewis","year":"2012","journal-title":"Clin Pharmacol Biopharmaceut."},{"key":"10.1016\/j.bmcl.2023.129574_b0140","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1021\/bi00009a003","article-title":"The 2.46. ANG. resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate","volume":"34","author":"Egloff","year":"1995","journal-title":"Biochemistry."},{"key":"10.1016\/j.bmcl.2023.129574_b0145","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/acs.jafc.1c02351","article-title":"Pancreatic Triglyceride Lipase Inhibitors Derived from Natural Products: How To Dig into the Truth","volume":"69","author":"Zhang","year":"2021","journal-title":"J Agric Food Chem."},{"key":"10.1016\/j.bmcl.2023.129574_b0150","first-page":"157","article-title":"Digestive lipases: Inactivation by phosphonates. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid","volume":"1210","author":"Marguet","year":"1994","journal-title":"Metabolism."},{"key":"10.1016\/j.bmcl.2023.129574_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115853","article-title":"Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors","volume":"29","author":"Huo","year":"2021","journal-title":"Bioorg Med Chem."},{"key":"10.1016\/j.bmcl.2023.129574_b0160","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/acs.jnatprod.0c01387","article-title":"Natural isoflavones and semisynthetic derivatives as pancreatic lipase inhibitors","volume":"84","author":"Cardullo","year":"2021","journal-title":"J Nat Prod."},{"key":"10.1016\/j.bmcl.2023.129574_b0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00217-011-1491-z","article-title":"Probing the interaction between 3 flavonoids and pancreatic lipase by methods of fluorescence spectroscopy and enzymatic kinetics","volume":"233","author":"Li","year":"2011","journal-title":"Eur Food Res Technol."},{"key":"10.1016\/j.bmcl.2023.129574_b0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.17113\/ftb.55.04.17.5138","article-title":"In vitro inhibition of pancreatic lipase by polyphenols: A kinetic, fluorescence spectroscopy and molecular docking study","volume":"55","author":"Martinez-Gonzalez","year":"2017","journal-title":"Food Technol Biotechnol."},{"key":"10.1016\/j.bmcl.2023.129574_b0175","first-page":"277","article-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006","journal-title":"Third Edition Ed. Springer"},{"key":"10.1016\/j.bmcl.2023.129574_b0180","first-page":"37","article-title":"Enzyme kinetics in drug metabolism: fundamentals and applications","author":"Nagar","year":"2014","journal-title":"Springer"},{"key":"10.1016\/j.bmcl.2023.129574_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13321-021-00522-2","article-title":"GNINA 1.0: molecular docking with deep learning","volume":"13","author":"McNutt","year":"2021","journal-title":"J Cheminf."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:13:33Z","timestamp":1778789613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23004523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":37,"alternative-id":["S0960894X23004523"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129574","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, biological evaluation and molecular docking of alkoxyaurones as potent pancreatic lipase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129574","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129574"}}