{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:07:38Z","timestamp":1756462058704,"version":"3.40.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bmcl.2023.129576","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T04:16:20Z","timestamp":1701836180000},"page":"129576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A conformationally-locked p-hydroxybenzylidene imidazolinone derivative for detecting A\u03b242 aggregation"],"prefix":"10.1016","volume":"98","author":[{"given":"Anyang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulziba","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-0330","authenticated-orcid":false,"given":"Jinwu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129576_b0005","doi-asserted-by":"crossref","unstructured":"2020 Alzheimer's disease facts and figures, Alzheimers Dement., 16 (2020) 391-460. https:\/\/doi.org\/10.1002\/alz.12068.","DOI":"10.1002\/alz.12068"},{"key":"10.1016\/j.bmcl.2023.129576_b0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40035-018-0107-y","article-title":"Alzheimer's disease hypothesis and related therapies","volume":"7","author":"Du","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bmcl.2023.129576_b0015","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41580-018-0060-8","article-title":"A new era for understanding amyloid structures and disease","volume":"19","author":"Iadanza","year":"2018","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bmcl.2023.129576_b0020","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(13)70090-5","article-title":"Tau pathology and neurodegeneration","volume":"12","author":"Spillantini","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bmcl.2023.129576_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111982","article-title":"Biological applications of near-infrared fluorescence dye probes in monitoring Alzheimer's disease","volume":"187","author":"Gyasi","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129576_b0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/acscentsci.8b00951","article-title":"Frontiers in probing alzheimer's disease biomarkers with fluorescent small molecules","volume":"5","author":"Jun","year":"2019","journal-title":"ACS Cent Sci"},{"key":"10.1016\/j.bmcl.2023.129576_b0035","article-title":"Fluorescence detection and dissociation of amyloid - \u03b2 species for the treatment of alzheimer's disease","volume":"2","author":"Lv","year":"2019","journal-title":"Adv Ther"},{"key":"10.1016\/j.bmcl.2023.129576_b0040","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.bioconjchem.9b00695","article-title":"Development of near-infrared fluorescent probes for use in alzheimer's disease diagnosis","volume":"31","author":"Yang","year":"2020","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.bmcl.2023.129576_b0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/biom11020198","article-title":"Different aggregation pathways and structures for A\u03b240 and A\u03b242 peptides","volume":"11","author":"Wang","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bmcl.2023.129576_b0050","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1002\/1873-3468.13919","article-title":"Internalisation and toxicity of amyloid-beta 1\u201342 are influenced by its conformation and assembly state rather than size","volume":"594","author":"Vadukul","year":"2020","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmcl.2023.129576_b0055","doi-asserted-by":"crossref","first-page":"16397","DOI":"10.1021\/ja405239v","article-title":"Design and synthesis of curcumin analogs for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease","volume":"135","author":"Zhang","year":"2013","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2023.129576_b0060","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1039\/C7SC02050C","article-title":"Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species","volume":"8","author":"Li","year":"2017","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmcl.2023.129576_b0065","doi-asserted-by":"crossref","first-page":"13503","DOI":"10.1021\/jacs.5b06190","article-title":"Chemical fluorescent probe for detection of abeta oligomers","volume":"137","author":"Teoh","year":"2015","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2023.129576_b0070","doi-asserted-by":"crossref","first-page":"8865","DOI":"10.1039\/C6CC02741E","article-title":"A spiropyran-based fluorescent probe for the specific detection of beta-amyloid peptide oligomers in Alzheimer's disease","volume":"(Camb),52","author":"Lv","year":"2016","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmcl.2023.129576_b0075","doi-asserted-by":"crossref","first-page":"8279","DOI":"10.1039\/C7SC03974C","article-title":"Fluoro-substituted cyanine for reliable in vivo labelling of amyloid-beta oligomers and neuroprotection against amyloid-beta induced toxicity","volume":"8","author":"Li","year":"2017","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmcl.2023.129576_b0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1039\/C9CC08894F","article-title":"Highly specific detection of Abeta oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a \u201cV-shaped\u201d spatial conformation","volume":"56","author":"Yang","year":"2020","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.bmcl.2023.129576_b0085","doi-asserted-by":"crossref","unstructured":"F. Zeng J. Yang X. Li et al. Versatile near-infrared fluorescent probe for in vivo detection of Abeta oligomers Bioorg. Med. Chem. 28 2020 115559.https:\/\/doi.org\/10.1016\/j.bmc.2020.115559.","DOI":"10.1016\/j.bmc.2020.115559"},{"key":"10.1016\/j.bmcl.2023.129576_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121830","article-title":"Amyloid-beta oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self- aggregation and amyloid-beta induced ROS generation","volume":"224","author":"Wang","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.bmcl.2023.129576_b0095","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1039\/D0SC02060E","article-title":"Differentiating Abeta40 and Abeta42 in amyloid plaques with a small molecule fluorescence probe","volume":"11","author":"Yang","year":"2020","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmcl.2023.129576_b0100","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1039\/D0AN01180K","article-title":"Novel D-\u03c0-A type near-infrared fluorescent probes for the detection of Abeta40 aggregates","volume":"145","author":"Lv","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.bmcl.2023.129576_b0105","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1021\/ja037944j","article-title":"Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe","volume":"126","author":"Gabe","year":"2004","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2023.129576_b0110","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1021\/cr078381n","article-title":"BODIPY dyes and their derivatives: syntheses and spectroscopic properties","volume":"107","author":"Loudet","year":"2007","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2023.129576_b0115","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1021\/acs.analchem.5b00191","article-title":"Capillary electrophoresis strategy to monitor the released and remaining nitric oxide from the same single cell using a specially designed water-soluble fluorescent probe","volume":"87","author":"Zhang","year":"2015","journal-title":"Anal Chem"},{"key":"10.1016\/j.bmcl.2023.129576_b0120","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1002\/ejoc.201500721","article-title":"Bioinspired fluorescent dyes based on a conformationally locked chromophore of the fluorescent protein kaede","volume":"2015","author":"Baleeva","year":"2015","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmcl.2023.129576_b0125","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1021\/ja710388h","article-title":"Syntheses of highly fluorescent GFP-chromophore analogues","volume":"130","author":"Wu","year":"2008","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2023.129576_b0130","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1021\/acs.accounts.7b00554","article-title":"Elucidating the structures of amyloid oligomers with macrocyclic beta-hairpin peptides: insights into alzheimer's disease and other amyloid diseases","volume":"51","author":"Kreutzer","year":"2018","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.bmcl.2023.129576_b0135","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1039\/C9CC00113A","article-title":"A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid","volume":"55","author":"Tan","year":"2019","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.bmcl.2023.129576_b0140","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.1039\/C7CC05056A","article-title":"Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-beta plaques","volume":"53","author":"Yan","year":"2017","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.bmcl.2023.129576_b0145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jcc.21628","article-title":"Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water","volume":"32","author":"Lee","year":"2011","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmcl.2023.129576_b0150","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1073\/pnas.0506723102","article-title":"3D structure of Alzheimer's amyloid-beta(1\u201342) fibrils","volume":"102","author":"Luhrs","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.bmcl.2023.129576_b0155","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1021\/ol049258a","article-title":"Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes","volume":"6","author":"Zhang","year":"2004","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2023.129576_b0160","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1021\/jacs.8b04404","article-title":"A general method to increase stokes shift by introducing alternating vibronic structures","volume":"140","author":"Ren","year":"2018","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2023.129576_b0165","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1039\/D2SC03833A","article-title":"Imaging of hypochlorous acid in mitochondria using an asymmetric near-infrared fluorescent probe with large Stokes shift","volume":"13","author":"Hu","year":"2022","journal-title":"Chem Sci"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23004547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:06:31Z","timestamp":1726848391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23004547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":33,"alternative-id":["S0960894X23004547"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129576","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A conformationally-locked p-hydroxybenzylidene imidazolinone derivative for detecting A\u03b242 aggregation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129576"}}