{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:34:34Z","timestamp":1784291674898,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bmcl.2024.129670","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T03:52:20Z","timestamp":1708487540000},"page":"129670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Re-exploration of tetrahydro-\u03b2-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities"],"prefix":"10.1016","volume":"102","author":[{"given":"Wen","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baibei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.129670_b0005","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/sj.onc.1210620","article-title":"Histone deacetylase inhibitors: molecular mechanisms of action","volume":"26","author":"Xu","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2024.129670_b0010","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1158\/1541-7786.MCR-07-0324","article-title":"Histone deacetylase inhibitors: overview and perspectives","volume":"5","author":"Dokmanovic","year":"2007","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.bmcl.2024.129670_b0015","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"de Ruijter","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.bmcl.2024.129670_b0020","doi-asserted-by":"crossref","first-page":"11672","DOI":"10.1021\/acs.jmedchem.3c01160","article-title":"Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms","volume":"66","author":"Mukherjee","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113332","article-title":"Histone deacetylase 2: A potential therapeutic target for cancer and neurodegenerative disorders","volume":"216","author":"Gediya","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejmech.2018.12.039","article-title":"Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview","volume":"164","author":"Banerjee","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0035","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","article-title":"HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor","volume":"18","author":"Kovacs","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.bmcl.2024.129670_b0040","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1242\/jcs.046813","article-title":"Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6","volume":"122","author":"Zilberman","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bmcl.2024.129670_b0045","article-title":"Histone deacetylase-6 modulates Tau function in Alzheimer's disease","volume":"1869","author":"Qureshi","year":"2022","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmcl.2024.129670_b0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molcel.2007.05.033","article-title":"HDAC6 modulates cell motility by altering the acetylation level of cortactin","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.bmcl.2024.129670_b0055","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s13402-022-00704-6","article-title":"HDAC6: A unique HDAC family member as a cancer target","volume":"45","author":"Kaur","year":"2022","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.bmcl.2024.129670_b0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s43018-022-00494-8","article-title":"HDAC6 score: to treat or not to treat?","volume":"4","author":"Hey","year":"2023","journal-title":"Nat Cancer"},{"key":"10.1016\/j.bmcl.2024.129670_b0065","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1021\/acs.jmedchem.0c01782","article-title":"A review of progress in histone deacetylase 6 inhibitors research: structural specificity and functional diversity","volume":"64","author":"Zhang","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115776","article-title":"Tetrahydro-beta-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity","volume":"260","author":"Chen","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111950","article-title":"Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity","volume":"187","author":"Chen","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0080","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.3390\/molecules28217323","article-title":"Design, synthesis, and antiproliferative activity of selective histone deacetylases 6 inhibitors containing a tetrahydropyridopyrimidine scaffold","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2024.129670_b0085","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1182\/blood-2011-10-387365","article-title":"Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma","volume":"119","author":"Santo","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2024.129670_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.129015","article-title":"Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease","volume":"76","author":"Li","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129670_b0095","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2217\/epi-2023-0373","article-title":"Histone deacetylase 6: at the interface of cancer and neurodegeneration","volume":"15","author":"Pu","year":"2023","journal-title":"Epigenomics"},{"key":"10.1016\/j.bmcl.2024.129670_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113874","article-title":"Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010\u20132020)","volume":"226","author":"Li","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0105","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/j.1471-4159.2008.05564.x","article-title":"Histone deacetylase 6 interacts with the microtubule-associated protein tau","volume":"106","author":"Ding","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.bmcl.2024.129670_b0110","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1073\/pnas.0907935106","article-title":"HDAC6 is a target for protection and regeneration following injury in the nervous system","volume":"106","author":"Rivieccio","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.bmcl.2024.129670_b0115","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1021\/ja102758v","article-title":"Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A","volume":"132","author":"Butler","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2024.129670_b0120","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1021\/acs.jmedchem.0c01940","article-title":"Melatonin- and ferulic acid-based HDAC6 selective inhibitors exhibit pronounced immunomodulatory effects in vitro and neuroprotective effects in a pharmacological Alzheimer's disease mouse model","volume":"64","author":"He","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0125","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1021\/acs.jmedchem.8b00151","article-title":"5-Aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating Alzheimer's disease phenotypes","volume":"61","author":"Lee","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0130","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1021\/acs.jmedchem.7b01922","article-title":"Why are the majority of active compounds in the CNS domain natural products? A critical analysis","volume":"61","author":"Bharate","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113815","article-title":"A review of synthetic bioactive tetrahydro-beta-carbolines: A medicinal chemistry perspective","volume":"225","author":"Wang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129670_b0140","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0959-437X(00)00174-X","article-title":"Functional significance of histone deacetylase diversity","volume":"11","author":"Khochbin","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.bmcl.2024.129670_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129148","article-title":"Discovery of indole-piperazine derivatives as selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting activities and neuroprotective activities","volume":"81","author":"Liang","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129670_b0150","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1021\/acschemneuro.7b00488","article-title":"Sarcodonin G derivatives exhibit distinctive effects on neurite outgrowth by modulating NGF signaling in PC12 cells","volume":"9","author":"Cao","year":"2018","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.bmcl.2024.129670_b0155","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24000726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24000726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:49:29Z","timestamp":1760773769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X24000726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":31,"alternative-id":["S0960894X24000726"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129670","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Re-exploration of tetrahydro-\u03b2-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129670"}}