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Mice were procured from animal breeding facilities at CDRI Lucknow. (a) Peters, W. Techniques for the study of drug response in experimental malaria. In Chemotherapy and drug resistance in malaria; Academic Press: London, 1970; pp 64-136. (b) In vivo test procedure: The colony bred Swiss albino mice (25 \u00b1 1g) were inoculated with 1X106 parasitized RBC on day zero and treatment was administered to a group of five mice at each dose, from day 0 to 3, in two divided doses daily. The drug dilution of compounds 11a, 13a-e, and 15a-b were prepared in groundnut oil so as to contain the required amount of the drug (0.3 mg for a dose of 24 mg\/kg, 0.15 mg for a dose of 12 mg\/kg and 0.075 mg for a dose of 6 mg\/kg) in 0.1 ml and administered via oral and intramuscular routes for each dose. Parasitaemia level were recorded from thin blood smears on day 4 and subsequently twice a week till day 28. The treated mice surviving beyond day 28 were recorded as Swiss mice protected by the drug.30-31 Mice treated with \u03b2-arteether served as positive control."},{"key":"10.1016\/j.bmcl.2024.129700_b0150","unstructured":"(a) 100% suppression of parasitaemia means no parasites were detected in 50 oil immersion microscopic fields, parasites if at all presents were below the detection limit. The parasites present below the detection limit could multiply and eventually could be detected during observation on subsequent days. In such cases though the drug was providing near 100% suppression of the parasitaemia on day 4 but would not provide full protection to the treated mice in the 28 days survival assay. Multidrug-resistant Plasmodium yoelii nigeriensis used in this study is resistant to chloroquine, mefloquine and halofantrine. (b) 100% protection means all the treated mice survived till day 28. 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