{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:06:13Z","timestamp":1778789173432,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008409","name":"Ministerio de Fomento","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["112S182"],"award-info":[{"award-number":["112S182"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["KANSIL-2016H121540"],"award-info":[{"award-number":["KANSIL-2016H121540"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007467","name":"School of Medicine, Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007467","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018718","name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bmcl.2024.129775","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T17:49:40Z","timestamp":1714326580000},"page":"129775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells"],"prefix":"10.1016","volume":"106","author":[{"given":"M.","family":"Fatih Polat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irem","family":"Durmaz \u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-0496","authenticated-orcid":false,"given":"P\u0131nar","family":"Kul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rengul","family":"Cetin Atalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral","family":"Tuncbilek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.129775_b0005","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bmcl.2024.129775_b0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2024.129775_b0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11894-015-0442-4","article-title":"New treatment modalities for hepatocellular cancer","volume":"17","author":"Mauer","year":"2015","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.bmcl.2024.129775_b0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.sla.0000197706.21803.a1","article-title":"Early and late recurrence after liver resection for hepatocellular carcinoma","volume":"243","author":"Portolani","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.bmcl.2024.129775_b0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/bmb\/ldl020","article-title":"Thiopurines, DNA damage, DNA repair and therapy-related cancer","volume":"79\u201380","author":"Karran","year":"2006","journal-title":"Br Med Bull"},{"key":"10.1016\/j.bmcl.2024.129775_b0030","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.leukres.2003.11.013","article-title":"Metabolic response patterns of nucleotides in B-cell chronic lymphocytic leukaemias to cladribine, fludarabine and deoxycoformycin","volume":"28","author":"Wilson","year":"2004","journal-title":"Leukemia Res"},{"key":"10.1016\/j.bmcl.2024.129775_b0035","first-page":"845","article-title":"Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma","volume":"37","author":"Nakamura","year":"2010","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bmcl.2024.129775_b0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(85)80182-4","article-title":"On the importance of deoxyribonucleotide pools in the senescence of cultured human diploid fibroblasts","volume":"179","author":"Dick","year":"1985","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmcl.2024.129775_b0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1345\/aph.10096","article-title":"Fluorouracil and the new oral fluorinated pyrimidines","volume":"35","author":"Kuhn","year":"2001","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.bmcl.2024.129775_b0050","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1038\/sj.onc.1207229","article-title":"Mechanisms of apoptosis induction by nucleoside analogs","volume":"22","author":"Sampath","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2024.129775_b0055","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/leu.2011.37","article-title":"Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia","volume":"25","author":"Escherich","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.bmcl.2024.129775_b0060","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2174\/138955706776876212","article-title":"Pharmacological and clinical studies on purine nucleoside analogs- new anticancer agents","volume":"6","author":"Lech-Maranda","year":"2006","journal-title":"Mini-Reviews Med Chem."},{"key":"10.1016\/j.bmcl.2024.129775_b0065","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1021\/jm3001532","article-title":"Synthesis of Novel 6-(4-Substituted piperazine-1-yl)-9-(\u03b2- d -ribofuranosyl)purine Derivatives, Which Lead to Senescence-Induced Cell Death in Liver Cancer Cells","volume":"55","author":"Tuncbilek","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129775_b0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejmech.2014.10.080","article-title":"Synthesis of novel substituted purine derivatives and identification of the cell death mechanism","volume":"89","author":"Demir","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129775_b0075","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1871520622666220905122346","article-title":"A Novel 6,8,9-Trisubstituted Purine Analogue Drives Breast Cancer Luminal A Subtype MCF-7 to Apoptosis and Senescence through Hsp70 Inhibition","volume":"23","author":"Kul","year":"2023","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.bmcl.2024.129775_b0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bmcl.2017.12.070","article-title":"Synthesis of novel 6-substituted amino-9-(\u03b2-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells","volume":"28","author":"Tuncbilek","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129775_b0085","first-page":"858","volume":"24","author":"Ayta\u00e7","year":"2016","journal-title":"Novel Triazolothiadiazines Act as Potent Anticancer Agents in Liver Cancer Cells through Akt and ASK-1 Proteins."},{"key":"10.1016\/j.bmcl.2024.129775_b0090","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bmcl.2024.129775_b0095","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2024.129775_b0100","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129775_b0105","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1023\/A:1020444330011","article-title":"Rate-limited steps of human oral absorption and QSAR studies","volume":"19","author":"Zhao","year":"2002","journal-title":"Pharm Res"},{"key":"10.1016\/j.bmcl.2024.129775_b0110","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2400177X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2400177X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:40:23Z","timestamp":1778517623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2400177X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":22,"alternative-id":["S0960894X2400177X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129775","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129775"}}