{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T18:49:37Z","timestamp":1763837377227},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bmcl.2024.129793","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T15:29:33Z","timestamp":1715354973000},"page":"129793","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, synthesis, and biological evaluation of new bis-benzylisoquinoline-based analogues as potential neuromuscular blocking agents"],"prefix":"10.1016","volume":"108","author":[{"given":"Lin","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.129793_b0005","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2174\/0929867023369466","article-title":"Synthesis and structure-activity relationships of neuromuscular blocking agents","volume":"9","author":"Tuba","year":"2002","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmcl.2024.129793_b0010","series-title":"The Wondrous story of anesthesia","first-page":"671","article-title":"A history of neuromuscular block and its antagonism","author":"Caldwell","year":"2014"},{"key":"10.1016\/j.bmcl.2024.129793_b0015","series-title":"Anesthesiology","first-page":"149","article-title":"Nondepolarizing neuromuscular blocking agents","author":"Bettendorf","year":"2017"},{"key":"10.1016\/j.bmcl.2024.129793_b0020","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.apsb.2023.01.013","article-title":"8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases","volume":"13","author":"Knez","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmcl.2024.129793_b0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2044.1948.tb06772.x","article-title":"Muscle relaxants in clinical practice","volume":"3","author":"Edwards","year":"1948","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bmcl.2024.129793_b0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1054\/cacc.2003.0438","article-title":"Muscle relaxants: past, present and future","volume":"14","author":"Prior","year":"2003","journal-title":"Curr Anaesth Crit Care"},{"key":"10.1016\/j.bmcl.2024.129793_b0035","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bja\/87.5.755","article-title":"Structure, conformation, and action of neuromuscular blocking drugs","volume":"87","author":"Lee","year":"2001","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bmcl.2024.129793_b0040","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.apsb.2020.05.005","article-title":"Interacting with \u03b17 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages","volume":"10","author":"Liu","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmcl.2024.129793_b0045","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/j.1365-2044.1992.tb03139.x","article-title":"A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia","volume":"47","author":"Booth","year":"1992","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bmcl.2024.129793_b0050","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2165\/00002018-199410060-00002","article-title":"Adverse effects of nondepolarising neuromuscular blocking agents: incidence, prevention and management","volume":"10","author":"Abel","year":"1994","journal-title":"Drug Saf"},{"key":"10.1016\/j.bmcl.2024.129793_b0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00000542-199607000-00023","article-title":"Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats","volume":"85","author":"Wastila","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bmcl.2024.129793_b0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/0310057X9902700406","article-title":"Fisher, Cisatracurium and atracurium as antigens","volume":"27","author":"McD","year":"1999","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.bmcl.2024.129793_b0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00044-005-0136-9","article-title":"Synthesis and neuromuscular blocking activity of 16\u03b2-piperidino epiandrosterone derivatives","volume":"14","author":"Dubey","year":"2005","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmcl.2024.129793_b0070","doi-asserted-by":"crossref","first-page":"A310","DOI":"10.1097\/00000542-198509001-00310","article-title":"Elimination of atracurium in humans: contribution of Hofmann elimination and ester hydrolysis","volume":"63","author":"Fisher","year":"1985","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bmcl.2024.129793_b0075","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1007\/s00044-023-03128-5","article-title":"The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism","volume":"32","author":"Khojasteh","year":"2023","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmcl.2024.129793_b0080","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/bja\/75.5.588","article-title":"Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine","volume":"75","author":"Naguib","year":"1995","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bmcl.2024.129793_b0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1213\/00000539-199801000-00025","article-title":"The cerebral and cardiovascular effects of cisatracurium and atracurium in neurosurgical patients","volume":"86","author":"Schramm","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bmcl.2024.129793_b0090","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.apsb.2020.12.005","article-title":"An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation","volume":"11","author":"Harms","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmcl.2024.129793_b0095","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1021\/jm020574+","article-title":"Boros, Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys","volume":"46","author":"Eric","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129793_b0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/jo01232a007","article-title":"Optically active quaternary ammonium salts from d- and l-2-octyl p-bromobenzenesulfonate and tertiary amines","volume":"1","author":"Cary","year":"1936","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2024.129793_b0105","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1021\/jo960057x","article-title":"Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. studies on direct and indirect reductive amination procedures","volume":"61","author":"Abdel-Magid","year":"1996","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2024.129793_b0110","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1021\/ol9911573","article-title":"Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates","volume":"1","author":"Samano","year":"1996","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2024.129793_b0115","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.1365-2044.1998.00283.x","article-title":"Neuromuscular interactions between mivacurium and esmolol in rabbits","volume":"53","author":"Kim","year":"1998","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bmcl.2024.129793_b0120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00000542-200107000-00048","article-title":"Hofmann, Schmofmann: Atracurium undergoes michael elimination","volume":"95","author":"Alston","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bmcl.2024.129793_b0125","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00000542-199702000-00008","article-title":"Pharmacokinetics of mivacurium isomers and their metabolites in healthy volunteers after intravenous bolus administration","volume":"86","author":"Lacroix","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bmcl.2024.129793_b0130","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41594-022-00737-3","article-title":"Structural mechanism of muscle nicotinic receptor desensitization and block by curare","volume":"29","author":"Rahman","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.bmcl.2024.129793_b0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2009","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmcl.2024.129793_b0140","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1097\/CCM.0000000000002027","article-title":"Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient","volume":"44","author":"Murray","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bmcl.2024.129793_b0145","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00003246-200201000-00021","article-title":"Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient","volume":"30","author":"Murray","year":"2002","journal-title":"Crit Care Med"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24001951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24001951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:58:00Z","timestamp":1717635480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X24001951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":29,"alternative-id":["S0960894X24001951"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129793","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of new bis-benzylisoquinoline-based analogues as potential neuromuscular blocking agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129793"}}