{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:12:57Z","timestamp":1789269177233,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"am","delay-in-days":297,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC2DK126122"],"award-info":[{"award-number":["UC2DK126122"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bmcl.2024.129810","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:43:50Z","timestamp":1716331430000},"page":"129810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Replacement of the hydroxamic acid group in the selective HDAC8 inhibitor PCI-34051"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-732X","authenticated-orcid":false,"given":"Keith","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5878-5757","authenticated-orcid":false,"given":"David A.","family":"Close","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-3091","authenticated-orcid":false,"given":"Paul A.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-4968","authenticated-orcid":false,"given":"Donna M.","family":"Huryn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.129810_b0005","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/leu.2008.9","article-title":"A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas","volume":"22","author":"Balasubramanian","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.bmcl.2024.129810_b0010","unstructured":"Buggy, J. J., Balasubramanian, S., Verner, E., Tai, V., Lee, C. Indole Derivatives as Inhibitors of Histone Deacetylase WO 2007\/109178, September 2007."},{"key":"10.1016\/j.bmcl.2024.129810_b0015","unstructured":"Verner, E., Balasubramanian, S., Buggy, J. Selective Inhibitors of Histone Deacetylase. WO 2009\/129335 A2, April 2009."},{"key":"10.1016\/j.bmcl.2024.129810_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/acsptsci.1c00243","article-title":"Validation of HDAC8 inhibitors as drug discovery starting points to treat acute kidney injury","volume":"5","author":"Long","year":"2022","journal-title":"ACS Pharmacol Transl Sci"},{"key":"10.1016\/j.bmcl.2024.129810_b0025","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4155\/fmc-2016-0117","article-title":"Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases","volume":"8","author":"Chakrabarti","year":"2016","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/epigenomes3030019","article-title":"Targeting HDAC complexes in asthma and COPD","volume":"3","author":"Zwinderman","year":"2019","journal-title":"Epigenomes"},{"key":"10.1016\/j.bmcl.2024.129810_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105750","article-title":"Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy","volume":"170","author":"Spreafico","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bmcl.2024.129810_b0040","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chembiol.2015.03.014","article-title":"Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism","volume":"22","author":"Olson","year":"2015","journal-title":"Chem Biol"},{"key":"10.1016\/j.bmcl.2024.129810_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cmdc.201500486","article-title":"Why hydroxamates may not be the best histone deacetylase inhibitors-what some may have forgotten or would rather forget?","volume":"11","author":"Shen","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2024.129810_b0050","first-page":"4704","article-title":"Mutagenicity of hydroxamic acids and the probable involvement of carbamoylation","volume":"40","author":"Skipper","year":"1980","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2024.129810_b0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0027-5107(77)90235-4","article-title":"Mutagenicity of hydroxamic acids for Salmonella typhimurium","volume":"56","author":"Wang","year":"1977","journal-title":"Mutat Res"},{"key":"10.1016\/j.bmcl.2024.129810_b0060","doi-asserted-by":"crossref","first-page":"10000","DOI":"10.1021\/acs.jmedchem.8b01087","article-title":"Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants","volume":"61","author":"Marek","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0065","doi-asserted-by":"crossref","first-page":"12460","DOI":"10.1021\/acs.jmedchem.0c00830","article-title":"Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight","volume":"63","author":"Ho","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0070","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2217\/fon-2016-0526","article-title":"Entinostat: a promising treatment option for patients with advanced breast cancer","volume":"13","author":"Connolly","year":"2017","journal-title":"Future Oncol"},{"key":"10.1016\/j.bmcl.2024.129810_b0075","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1021\/acsmedchemlett.0c00462","article-title":"Discovery of highly selective and potent HDAC3 inhibitors based on a 2-substituted benzamide zinc binding group","volume":"11","author":"Liu","year":"2020","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129810_b0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fchem.2020.00256","article-title":"Synthesis and biological evaluation of HDAC inhibitors with a novel zinc binding group","volume":"8","author":"He","year":"2020","journal-title":"Front Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0085","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1021\/acsmedchemlett.0c00302","article-title":"Selective class I HDAC inhibitors based on aryl ketone zinc binding induce HIV-1 protein for clearance","volume":"11","author":"Liu","year":"2020","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129810_b0090","doi-asserted-by":"crossref","first-page":"9538","DOI":"10.1021\/acs.inorgchem.8b01632","article-title":"Metal-binding isosteres as new scaffolds for metalloenzyme inhibitors","volume":"57","author":"Dick","year":"2018","journal-title":"Inorg Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0095","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/co2000373","article-title":"High-throughput screening of small molecule libraries using SAMDI mass spectrometry","volume":"13","author":"Gurard-Levin","year":"2011","journal-title":"ACS Comb Sci"},{"key":"10.1016\/j.bmcl.2024.129810_b0100","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1021\/ja0410237","article-title":"ChemDraw Ultra 9.0. CambridgeSoft, 100 CambridgePark Drive, Cambridge, MA 02140. www.cambridgesoft.com. See Web site for pricing options","volume":"127","author":"Cousins","year":"2005","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2024.129810_b0105","unstructured":"Huryn, D. H., Neil; Long, Keith; Panda, Jagannath; Joyasawal, Sipak Substituted indoles with inhibitory activity. WO2021243018A1, 2021."},{"key":"10.1016\/j.bmcl.2024.129810_b0110","unstructured":"https:\/\/www.criver.com\/products-services\/discovery-services\/screening-and-profiling-assays\/samdi-technology-asms-screening?region=3701."},{"key":"10.1016\/j.bmcl.2024.129810_b0115","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1021\/acs.jmedchem.3c00226","article-title":"The zinc-binding group effect: lessons from non-hydroxamic acid vorinostat analogs","volume":"66","author":"Geurs","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0120","doi-asserted-by":"crossref","first-page":"17174","DOI":"10.1016\/S0021-9258(17)44885-X","article-title":"Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A","volume":"265","author":"Yoshida","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bmcl.2004.10.074","article-title":"Identification of a potent non-hydroxamate histone deacteylase inhibitor by mechanism-based esign","volume":"15","author":"Suzuki","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129810_b0130","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.bmcl.2004.03.063","article-title":"Thiol-based SAHA analogues as potent histone deacetylase inhibitors","volume":"14","author":"Suzuki","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129810_b0135","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bioorg.2018.01.015","article-title":"A simple, cheap but reliable method for evaluation of zinc chelating properties","volume":"77","author":"Catapano","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0140","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmc.2011.06.030","article-title":"Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors","volume":"19","author":"Whitehead","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0145","doi-asserted-by":"crossref","first-page":"8634","DOI":"10.1021\/acs.jmedchem.0c01025","article-title":"Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and selective HDAC8 targeting","volume":"63","author":"Hassan","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129810_b0150","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/acsmedchemlett.1c00702","article-title":"DeterMINATION OF SLOW-BINDing HDAC inhibitor potency and subclass selectivity","volume":"13","author":"Moreno-Yruela","year":"2022","journal-title":"ACS Med Chem Lett"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24002129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24002129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T20:58:20Z","timestamp":1717621100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X24002129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":30,"alternative-id":["S0960894X24002129"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129810","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Replacement of the hydroxamic acid group in the selective HDAC8 inhibitor PCI-34051","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129810"}}