{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:30:27Z","timestamp":1779921027985,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bmcl.2024.129864","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T23:37:39Z","timestamp":1719445059000},"page":"129864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety"],"prefix":"10.1016","volume":"110","author":[{"given":"Kaoru","family":"Adachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Suma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Orita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Furuzono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Ohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.129864_b0005","unstructured":"HIV\/AIDS fact sheet. World Health Organization. Accessed 13 November 2023. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hiv-aids."},{"key":"10.1016\/j.bmcl.2024.129864_b0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2022.22246","volume":"329","author":"Gandhi","year":"2023","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.bmcl.2024.129864_b0015","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.7954","volume":"3","author":"Marcus","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bmcl.2024.129864_b0020","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJMra1004180","volume":"365","author":"Wainberg","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2024.129864_b0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/clpt.2012.202","volume":"93","author":"Barton","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.bmcl.2024.129864_b0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12977-022-00608-1","volume":"19","author":"Zhao","year":"2022","journal-title":"Retrovirology"},{"key":"10.1016\/j.bmcl.2024.129864_b0035","doi-asserted-by":"crossref","first-page":"33528","DOI":"10.1074\/jbc.M303594200","volume":"278","author":"Maertens","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0040","doi-asserted-by":"crossref","first-page":"25517","DOI":"10.1074\/jbc.M501378200","volume":"280","author":"Emiliani","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0045","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jmb.2006.10.094","volume":"365","author":"Busschots","year":"2007","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmcl.2024.129864_b0050","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nm1329","volume":"11","author":"Ciuffi","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.bmcl.2024.129864_b0055","doi-asserted-by":"crossref","first-page":"11498","DOI":"10.1128\/JVI.00801-06","volume":"80","author":"De Rijck","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.bmcl.2024.129864_b0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1126\/science.1132319","volume":"314","author":"Llano","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2024.129864_b0065","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2016.07.044","volume":"166","author":"Kessl","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2024.129864_b0070","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1073\/pnas.1300703110","volume":"110","author":"Jurado","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmcl.2024.129864_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004171","volume":"10","author":"Sharma","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmcl.2024.129864_b0080","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/acsmedchemlett.8b00269","volume":"9","author":"Jentsch","year":"2018","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129864_b0085","doi-asserted-by":"crossref","first-page":"15813","DOI":"10.1074\/jbc.M112.443390","volume":"288","author":"Feng","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1742-4690-10-57","volume":"10","author":"Desimmie","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.bmcl.2024.129864_b0095","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4690-10-144","volume":"10","author":"Le Rouzic","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.bmcl.2024.129864_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009671","volume":"17","author":"Maehigashi","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmcl.2024.129864_b0105","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nchembio.370","volume":"6","author":"Christ","year":"2010","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bmcl.2024.129864_b0110","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ml500002n","volume":"5","author":"Fader","year":"2014","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129864_b0115","doi-asserted-by":"crossref","first-page":"21189","DOI":"10.1074\/jbc.M112.347534","volume":"287","author":"Tsiang","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0120","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01843-21","volume":"96","author":"Ohata","year":"2022","journal-title":"J Virol"},{"key":"10.1016\/j.bmcl.2024.129864_b0125","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1021\/acs.jmedchem.8b01473","volume":"62","author":"Peese","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127742","volume":"33","author":"Sugiyama","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.129864_b0135","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1021\/acs.jmedchem.9b01681","volume":"63","author":"Li","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.129864_b0140","first-page":"12","volume":"14","author":"Gupta","year":"2016","journal-title":"PLoS Biol"},{"key":"10.1016\/j.bmcl.2024.129864_b0145","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1742-4690-5-74","volume":"5","author":"Rhee","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.bmcl.2024.129864_b0150","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1074\/jbc.M117.816793","volume":"293","author":"Bonnard","year":"2018","journal-title":"J Biol Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2400266X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2400266X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T03:14:55Z","timestamp":1722050095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2400266X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":30,"alternative-id":["S0960894X2400266X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129864","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129864"}}