{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:32:06Z","timestamp":1790771526923,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373739"],"award-info":[{"award-number":["82373739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1802000"],"award-info":[{"award-number":["2023YFA1802000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bmcl.2024.130044","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T18:23:51Z","timestamp":1732645431000},"page":"130044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect"],"prefix":"10.1016","volume":"116","author":[{"given":"Shuhua","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiabin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-3864","authenticated-orcid":false,"given":"Lei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2024.130044_b0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2024.130044_b0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/jm501212r","article-title":"Inhibitors of C-Jun N-terminal kinases: An Update","volume":"58","author":"Koch","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.130044_b0015","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1021\/acs.jmedchem.1c01947","article-title":"Unraveling the design and discovery of C-Jun N-terminal kinase inhibitors and their therapeutic potential in human diseases","volume":"65","author":"Zhu","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.130044_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00829","article-title":"The JNK signaling pathway in renal fibrosis","volume":"8","author":"Grynberg","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.bmcl.2024.130044_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107780","article-title":"Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and P38 MAPK-mediated NF-\u03baB signaling pathways","volume":"98","author":"Xiong","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmcl.2024.130044_b0030","article-title":"Induction of collagen I by CXCL10 in ovarian theca-stroma cells via the JNK pathway","volume":"13","author":"Wang","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.bmcl.2024.130044_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.679557","article-title":"Chaihu Guizhi Ganjiang decoction ameliorates pancreatic fibrosis via JNK\/mTOR signaling pathway","volume":"12","author":"Cui","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmcl.2024.130044_b0040","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1038\/sj.onc.1207981","article-title":"TGF-\u03b2 and HGF transmit the signals through JNK-dependent Smad2\/3 phosphorylation at the linker regions","volume":"23","author":"Mori","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2024.130044_b0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2013.01.004","article-title":"Roles of P38 MAPK and JNK in TGF-\u03921-induced human alveolar epithelial to mesenchymal transition","volume":"44","author":"Chen","year":"2013","journal-title":"Arch Med Res"},{"key":"10.1016\/j.bmcl.2024.130044_b0050","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1242\/jcs.019455","article-title":"Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-\u03921","volume":"121","author":"Alcorn","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bmcl.2024.130044_b0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1165\/rcmb.2008-0174OC","article-title":"C-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis","volume":"40","author":"Alcorn","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bmcl.2024.130044_b0060","doi-asserted-by":"crossref","first-page":"27021","DOI":"10.18632\/oncotarget.8395","article-title":"The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo","volume":"7","author":"Okada","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmcl.2024.130044_b0065","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"98","author":"Bennett","year":"2001","journal-title":"PNAS"},{"key":"10.1016\/j.bmcl.2024.130044_b0070","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1210\/en.2018-00083","article-title":"CC-401 promotes \u03b2-cell replication via pleiotropic consequences of DYRK1A\/B inhibition","volume":"159","author":"Abdolazimi","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.bmcl.2024.130044_b0075","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.bmcl.2011.12.027","article-title":"Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor","volume":"22","author":"Krenitsky","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2024.130044_b0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40169-016-0117-2","article-title":"JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers","volume":"5","author":"van der Velden","year":"2016","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.bmcl.2024.130044_b0085","article-title":"CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial","volume":"9","author":"Popmihajlov","year":"2022","journal-title":"BMJ Open Respir Res"},{"key":"10.1016\/j.bmcl.2024.130044_b0090","doi-asserted-by":"crossref","first-page":"16809","DOI":"10.1073\/pnas.0805677105","article-title":"Identification of a new JNK inhibitor targeting the JNK-JIP interaction site","volume":"105","author":"Stebbins","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.bmcl.2024.130044_b0095","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1248\/bpb.b22-00001","article-title":"Phosphatidylserine-specific phospholipase A1 alleviates lipopolysaccharide-induced macrophage inflammation by inhibiting MAPKs activation","volume":"45","author":"Zhang","year":"2022","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmcl.2024.130044_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115442","article-title":"Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor","volume":"256","author":"Qian","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2024.130044_b0105","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.4c01764","article-title":"Structure optimization of c-Jun N-terminal kinase 1 inhibitors for treating idiopathic pulmonary fibrosis","author":"Huang","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.130044_b0110","doi-asserted-by":"crossref","first-page":"8934","DOI":"10.1021\/acs.jmedchem.8b01148","article-title":"Lowering lipophilicity by adding carbon: one-carbon bridges of morpholines and piperazines","volume":"61","author":"Degorce","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2024.130044_b0115","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1021\/acsmedchemlett.9b00248","article-title":"Lowering lipophilicity by adding carbon: AzaSpiroHeptanes, a IogD lowering twist","volume":"10","author":"Degorce","year":"2019","journal-title":"ACS Med Chem Lett"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24004463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X24004463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:19:27Z","timestamp":1733944767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X24004463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"alternative-id":["S0960894X24004463"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.130044","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2024.130044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130044"}}