{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:20:53Z","timestamp":1790893253608,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["959516"],"award-info":[{"award-number":["959516"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI154189"],"award-info":[{"award-number":["R21AI154189"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006617","name":"Mental Health Association of Westchester County","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016048","name":"University of Texas at Tyler","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005349","name":"American Association of Colleges of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bmcl.2025.130113","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:20:45Z","timestamp":1738023645000},"page":"130113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A benzoxazolyl urea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"120","author":[{"given":"Emerson P.","family":"Heckler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaqat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrijan","family":"Bhattarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittnee","family":"Cagle-White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickalus C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik D.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Coover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May H.","family":"Abdel Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-6345","authenticated-orcid":false,"given":"Aurijit","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130113_b0005","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1039\/C9MD00330D","article-title":"Resisting resistance: gearing up for war","volume":"10","author":"Sarkar","year":"2019","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.bmcl.2025.130113_b0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2025.130113_b0015","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1021\/jm700967e","article-title":"Physicochemical properties of antibacterial compounds: implications for drug discovery","volume":"51","author":"O'Shea","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130113_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.2010.05828.x","article-title":"Challenges of antibacterial discovery revisited","volume":"1213","author":"Gwynn","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bmcl.2025.130113_b0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1469-0691.2006.01528.x","article-title":"Impact of antibiotic restrictions: the pharmaceutical perspective","volume":"12","author":"Power","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.bmcl.2025.130113_b0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","article-title":"Drugs for bad bugs: confronting the challenges of antibacterial discovery","volume":"6","author":"Payne","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmcl.2025.130113_b0035","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmcl.2025.130113_b0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jac\/40.1.135","article-title":"Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility","volume":"40","author":"Hiramatsu","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00042-09","article-title":"Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications","volume":"23","author":"Howden","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmcl.2025.130113_b0050","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jac\/42.2.199","article-title":"Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50","volume":"42","author":"Hanaki","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0055","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/AAC.44.9.2276-2285.2000","article-title":"Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50","volume":"44","author":"Cui","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1128\/JCM.41.1.5-14.2003","article-title":"Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus","volume":"41","author":"Cui","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmcl.2025.130113_b0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/AAC.01651-12","article-title":"VraT\/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus","volume":"57","author":"Boyle-Vavra","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0070","doi-asserted-by":"crossref","first-page":"12354","DOI":"10.1074\/jbc.M710010200","article-title":"A close-up view of the VraSR two-component system. A mediator of Staphylococcus aureus response to cell wall damage","volume":"283","author":"Belcheva","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2025.130113_b0075","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1128\/AAC.00356-06","article-title":"Role of VraSR in antibiotic resistance and antibiotic-induced stress response in Staphylococcus aureus","volume":"50","author":"Gardete","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0080","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1128\/JB.185.24.7103-7110.2003","article-title":"Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus","volume":"185","author":"Sieradzki","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmcl.2025.130113_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085873","article-title":"The role of the Staphylococcal VraTSR regulatory system on vancomycin resistance and vanA operon expression in vancomycin-resistant Staphylococcus aureus","volume":"9","author":"Qureshi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2025.130113_b0090","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1128\/AAC.00425-13","article-title":"Comprehensive identification of mutations responsible for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA)-to-VISA conversion in laboratory-generated VISA strains derived from hVISA clinical strain Mu3","volume":"57","author":"Matsuo","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.2000.2277","article-title":"Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method","volume":"269","author":"Kuroda","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmcl.2025.130113_b0100","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijantimicag.2007.08.012","article-title":"Microbiological and clinical study of methicillin-resistant Staphylococcus aureus (MRSA) carrying VraS mutation: changes in susceptibility to glycopeptides and clinical significance","volume":"31","author":"Kato","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bmcl.2025.130113_b0105","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/AAC.00720-10","article-title":"Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance","volume":"55","author":"Galbusera","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0110","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/AAC.01173-08","article-title":"Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus","volume":"53","author":"Cui","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0115","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/AAC.01213-10","article-title":"Mutational analyses of open reading frames within the vraSR operon and their roles in the cell wall stress response of Staphylococcus aureus","volume":"55","author":"McCallum","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0120","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1099\/mic.0.26426-0","article-title":"Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon","volume":"149","author":"Utaida","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.bmcl.2025.130113_b0125","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1073\/pnas.54.4.1133","article-title":"Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine","volume":"54","author":"Tipper","year":"1965","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2025.130113_b0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.mi.38.100184.002011","article-title":"The structure and mode of action of glycopeptide antibiotics of the vancomycin group","volume":"38","author":"Barna","year":"1984","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130113_b0135","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1128\/jb.179.8.2557-2566.1997","article-title":"Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus","volume":"179","author":"Sieradzki","year":"1997","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmcl.2025.130113_b0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1574-6968.2006.00384.x","article-title":"The VraS\/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus","volume":"262","author":"Boyle-Vavra","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.bmcl.2025.130113_b0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1365-2958.2003.03599.x","article-title":"Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus","volume":"49","author":"Kuroda","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.bmcl.2025.130113_b0150","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1128\/AAC.50.1.336-343.2006","article-title":"VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus","volume":"50","author":"Yin","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02593-18","article-title":"Identification of small molecules exhibiting oxacillin synergy through a novel assay for inhibition of vraTSR expression in methicillin-resistant Staphylococcus aureus","volume":"63","author":"Lee","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2025.130113_b0160","doi-asserted-by":"crossref","first-page":"11254","DOI":"10.1002\/anie.201206911","article-title":"Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus","volume":"51","author":"Harris","year":"2012","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.bmcl.2025.130113_b0165","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04861-22","article-title":"NH125 sensitizes Staphylococcus aureus to cell wall-targeting antibiotics through the inhibition of the VraS sensor histidine kinase","volume":"11","author":"Bhattarai","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.bmcl.2025.130113_b0170","doi-asserted-by":"crossref","first-page":"46213","DOI":"10.1021\/acsomega.2c04381","article-title":"\u03b2-lactamase suppression as a strategy to target methicillin-resistant Staphylococcus aureus: proof of concept","volume":"7","author":"Thomas","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmcl.2025.130113_b0175","unstructured":"Clinical and Laboratory Standards Institute, M100: Performance Standards for Antimicrobial Susceptibility Testing. Table 2C.; 2022."},{"key":"10.1016\/j.bmcl.2025.130113_b0180","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnv024","article-title":"Temporal expression of the staphylococcal enterotoxin D gene under NaCl stress conditions","volume":"362","author":"Sihto","year":"2015","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.bmcl.2025.130113_b0185","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/acsinfecdis.9b00096","article-title":"From antihistamine to anti-infective: loratadine inhibition of regulatory PASTA kinases in Staphylococci reduces biofilm formation and potentiates beta-lactam antibiotics and vancomycin in resistant strains of Staphylococcus aureus","volume":"5","author":"Cutrona","year":"2019","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmcl.2025.130113_b0190","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/cbdd.13361","article-title":"Tricyclic amine antidepressants suppress beta-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) by repressing mRNA levels of key resistance genes","volume":"92","author":"Gillard","year":"2018","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmcl.2025.130113_b0195","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/JCM.41.1.254-260.2003","article-title":"Rapid detection of methicillin-resistant Staphylococcus aureus directly from sterile or nonsterile clinical samples by a new molecular assay","volume":"41","author":"Francois","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmcl.2025.130113_b0200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/jb.158.2.513-516.1984","article-title":"Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus","volume":"158","author":"Hartman","year":"1984","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmcl.2025.130113_b0205","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/mdr.1997.3.409","article-title":"Massive reduction in methicillin resistance by transposon inactivation of the normal PBP2 in a methicillin-resistant strain of Staphylococcus aureus","volume":"3","author":"Pinho","year":"1997","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.bmcl.2025.130113_b0210","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1073\/pnas.191260798","article-title":"An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci","volume":"98","author":"Pinho","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2025.130113_b0215","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comp Chem"},{"key":"10.1016\/j.bmcl.2025.130113_b0220","doi-asserted-by":"crossref","unstructured":"Korb O, St\u00fctzle T, Exner TE. PLANTS: application of ant colony optimization to structure-based drug design. Berlin, Heidelberg: Springer Berlin Heidelberg; 2006. p. 247\u201358.","DOI":"10.1007\/11839088_22"},{"key":"10.1016\/j.bmcl.2025.130113_b0225","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/ci800298z","article-title":"Empirical scoring functions for advanced protein-ligand docking with PLANTS","volume":"49","author":"Korb","year":"2009","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmcl.2025.130113_b0230","unstructured":"Quest Graph\u2122 IC50 Calculator. AAT Bioquest Inc, https:\/\/www.aatbio.com\/tools\/ic50-calculator (accessed December 2024)."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T09:04:43Z","timestamp":1741511083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":46,"alternative-id":["S0960894X25000228"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130113","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A benzoxazolyl urea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130113"}}