{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:24:06Z","timestamp":1789079046868,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"am","delay-in-days":641,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-487"],"award-info":[{"award-number":["2024SF-YBXM-487"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bmcl.2025.130116","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T16:40:02Z","timestamp":1738168802000},"page":"130116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Optimization of clofibrate by carvacrol results in a new hypolipidemic compound with low hepatic injury"],"prefix":"10.1016","volume":"120","author":[{"given":"Xinyi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizi","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130116_b0005","first-page":"21","volume":"24","author":"Liang","year":"2022","journal-title":"J Storke"},{"key":"10.1016\/j.bmcl.2025.130116_b0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11096-021-01324-0","volume":"44","author":"Mitsuboshi","year":"2022","journal-title":"Int J Clin Pharm-Net"},{"key":"10.1016\/j.bmcl.2025.130116_b0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/eurheartj\/ehz785","volume":"41","author":"Laufs","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bmcl.2025.130116_b0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4070\/kcj.2016.46.2.135","volume":"46","author":"Han","year":"2016","journal-title":"Korean Circ J"},{"key":"10.1016\/j.bmcl.2025.130116_b0025","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.pan.2020.06.005","volume":"20","author":"Yang","year":"2020","journal-title":"Pancreatology"},{"key":"10.1016\/j.bmcl.2025.130116_b0030","first-page":"677","volume":"13","author":"Serpytis","year":"2012","journal-title":"J Pancreas"},{"key":"10.1016\/j.bmcl.2025.130116_b0035","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1001\/jama.289.22.3000","volume":"289","author":"Clark","year":"2003","journal-title":"JAMA-J Am Med Assoc"},{"key":"10.1016\/j.bmcl.2025.130116_b0040","first-page":"135","volume":"44","author":"Kametani","year":"2001","journal-title":"J Jap Diab Soc"},{"key":"10.1016\/j.bmcl.2025.130116_b0045","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/0192623317707271","volume":"45","author":"Maliver","year":"2017","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.bmcl.2025.130116_b0050","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0891-5849(99)00143-4","volume":"27","author":"Qu","year":"1999","journal-title":"Free Radical Bio Med"},{"key":"10.1016\/j.bmcl.2025.130116_b0055","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2131\/jts.23.2_113","volume":"23","author":"Kim","year":"1998","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.bmcl.2025.130116_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128844","volume":"72","author":"Liu","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130116_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128121","volume":"44","author":"Xie","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130116_b0070","first-page":"159","volume":"448","author":"Yeldandi","year":"2000","journal-title":"Mutat Res-Fund Mol M"},{"key":"10.1016\/j.bmcl.2025.130116_b0075","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0891-5849(01)00632-3","volume":"31","author":"Qu","year":"2001","journal-title":"Free Radical Bio Med"},{"key":"10.1016\/j.bmcl.2025.130116_b0080","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2645237","volume":"2016","author":"Samarghandian","year":"2016","journal-title":"Biochem Res Int"},{"key":"10.1016\/j.bmcl.2025.130116_b0085","first-page":"1380","volume":"18","author":"Jamhiri","year":"2019","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.bmcl.2025.130116_b0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12906-020-02937-0","volume":"20","author":"Li","year":"2020","journal-title":"BMC Complement Med"},{"key":"10.1016\/j.bmcl.2025.130116_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112961","volume":"259","author":"Bouhlali","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130116_b0100","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.3390\/ijms22105161","volume":"22","author":"Rahman","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2025.130116_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173028","volume":"874","author":"Chumboatong","year":"2020","journal-title":"Eur J Pharmacol"}],"updated-by":[{"DOI":"10.1016\/j.bmcl.2026.130658","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000}},{"DOI":"10.1016\/j.bmcl.2026.130658","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:13:53Z","timestamp":1778789633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25000253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"alternative-id":["S0960894X25000253"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130116","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of clofibrate by carvacrol results in a new hypolipidemic compound with low hepatic injury","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130116"}}