{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:05:26Z","timestamp":1777907126817,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"India Ministry of Science & Technology Department of Science and Technology","doi-asserted-by":"publisher","award":["DST\/INSPIRE\/04\/2018\/003541"],"award-info":[{"award-number":["DST\/INSPIRE\/04\/2018\/003541"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bmcl.2025.130143","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T03:04:02Z","timestamp":1739847842000},"page":"130143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oxime functionalized Chalcones: Unveiling a new class of Chalcones with potent Antiplasmodial activity against blood-stages of Plasmodium falciparum in culture"],"prefix":"10.1016","volume":"121","author":[{"given":"Reeta","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ayushee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoth","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Rangarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130143_bb0005","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1111\/j.1742-4658.2007.05997.x","article-title":"Malaria\u2212an overview","volume":"274","author":"Tuteja","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.bmcl.2025.130143_bb0010","doi-asserted-by":"crossref","unstructured":"Venkatesan P. The 2023 WHO World Malaria Report. Lancet Microbe. 2024;5:e214.","DOI":"10.1016\/S2666-5247(24)00016-8"},{"key":"10.1016\/j.bmcl.2025.130143_bb0015","first-page":"67","article-title":"Impact of the COVID-19 Pandemic on Malaria Control in Africa: A Preliminary Analysis","volume":"8","author":"Gao","year":"2023","journal-title":"Trop Med Infect Dis."},{"key":"10.1016\/j.bmcl.2025.130143_bb0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/0255-0857.83906","article-title":"Drug resistance in malaria","volume":"29","author":"Parija","year":"2011","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.bmcl.2025.130143_bb0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pt.2020.09.011","article-title":"Triple Artemisinin-Based Combination Therapies for Malaria \u2013 A New Paradigm?","volume":"37","author":"van der Pluijm","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmcl.2025.130143_bb0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40471-021-00271-8","article-title":"Impacts of Ecology, Parasite Antigenic Variation, and Human Genetics on RTS,S\/AS01e Malaria Vaccine Efficacy","volume":"8","author":"Bell","year":"2021","journal-title":"Curr. Epidemiol. Rep."},{"key":"10.1016\/j.bmcl.2025.130143_bb0035","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1021\/acs.chemrev.7b00020","article-title":"Chalcone: A Privileged Structure in Medicinal Chemistry","volume":"117","author":"Zhuang","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2025.130143_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.592654","article-title":"Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence","volume":"11","author":"Salehi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bmcl.2025.130143_bb0045","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.2174\/1385272819666141013224253","article-title":"Chalcones as Versatile Synthons for the Synthesis of 5- and 6-membered Nitrogen Heterocycles","volume":"18","author":"Albuquerque","year":"2014","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molstruc.2011.07.038","article-title":"Optical and structural properties of chalcone NLO single crystals","volume":"1005","author":"Rajesh Kumar","year":"2011","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmcl.2025.130143_bb0055","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/acs.cgd.2c01191","article-title":"Design Novel Chalcone Crystals for Enhancement of Nonlinear Optical Activity and Higher Molecular Structural Stability","volume":"23","author":"Xu","year":"2023","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.bmcl.2025.130143_bb0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00044-009-9202-z","article-title":"Synthesis and evaluation of antiinflammatory activity of substituted chalcone derivatives","volume":"19","author":"Zhang","year":"2010","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bmcl.2025.130143_bb0065","doi-asserted-by":"crossref","first-page":"11306","DOI":"10.3390\/ijms222111306","article-title":"Anticancer Activity of Natural and Synthetic Chalcones","volume":"22","author":"Constantinescu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bmcl.2025.130143_bb0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/13813455.2017.1360914","article-title":"Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profile","volume":"124","author":"Kocyigit","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.molstruc.2019.04.046","article-title":"Microwave assisted synthesis of chalcone and its polycyclic heterocyclic analogues as promising antibacterial agents: In vitro, in silico and DFT studies","volume":"1190","author":"Khan","year":"2019","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmcl.2025.130143_bb0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ejmech.2019.02.028","article-title":"Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation","volume":"167","author":"Espinoza-Hicks","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1573407212666161101152735","article-title":"An Improved Protocol for the Synthesis of Chalcones Containing Pyrazole with Potential Antimicrobial and Antioxidant Activity","volume":"14","author":"Kumari","year":"2018","journal-title":"Curr Bioactive Comp."},{"key":"10.1016\/j.bmcl.2025.130143_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.104852","article-title":"Design, synthesis and biological activity of chalcone derivatives containing pyridazine","volume":"16","author":"Chen","year":"2023","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0265068","article-title":"Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3carbonitrile and 2-amino-4H-pyran-3carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies","volume":"17","author":"Lagu","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2025.130143_bb0100","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.3390\/molecules26144332","article-title":"Reaction of Chalcones with Cellular Thiols. The Effect of the 4-Substitution of Chalcones and Protonation State of the Thiols on the Addition Process. Diastereoselective Thiol Addition","volume":"26","author":"Kenari","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130143_bb0105","first-page":"64","article-title":"Chalcones as an Emerging Lead Molecule for Antimalarial Therapy: A Review","volume":"1","author":"Sinha","year":"2013","journal-title":"J Mod Med Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0110","doi-asserted-by":"crossref","first-page":"6894","DOI":"10.1002\/slct.201601761","article-title":"Palladium-Catalyzed Rapid Methoxylation and Deuteriomethoxylation of Bromo\u2013chalcones: Uncovering the Catalytic Activity of the Pd\/tBuXPhos Catalyst System","volume":"21","author":"Reeta","year":"2016","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmcl.2025.130143_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jfluchem.2016.04.013","article-title":"A general and efficient Pd-catalyzed rapid 2-fluoroethoxylation of bromo-chalcones","volume":"186","author":"Rangarajan","year":"2016","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0120","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/cjoc.201900540","article-title":"An Easy Access to Oxime Ethers by Pd-Catalyzed C\u2014O Cross-Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes","volume":"38","author":"Reeta","year":"2020","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bioorg.2019.02.016","article-title":"Synthesis of novel chalcones through palladium-catalyzed C\u2013O cross-coupling reaction of bromo-chalcones with ethyl acetohydroxamate and their antiplasmodial evaluation against Plasmodium falcipuram in vitro","volume":"86","author":"Reeta","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0130","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1039\/C9NJ05124D","article-title":"Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C\u2013O cross-coupling of aldoximes with aryl bromides and bromo-chalcones","volume":"44","author":"Reeta","year":"2020","journal-title":"New J. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131817","article-title":"Aldoxime- and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors","volume":"1250","author":"Oh","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmcl.2025.130143_bb0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1128\/AAC.19.1.56","article-title":"Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities","volume":"19","author":"Tsuchiya","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2025.130143_bb0145","first-page":"72","article-title":"Comparative in vitro Antibacterial Activity of Aztreonam against Clinical Isolates of Gram-Negative Bacteria","volume":"35","author":"Shibl","year":"1989","journal-title":"Chemotheraphy"},{"key":"10.1016\/j.bmcl.2025.130143_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/41.suppl_2.1","article-title":"Roxithromycin: review of its antimicrobial activity","volume":"41","author":"Bryskier","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmcl.2025.130143_bb0155","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1365-2036.2000.00779.x","article-title":"Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-infammatory profile in inflammatory bowel disease","volume":"14","author":"Carty","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bmcl.2025.130143_bb0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0928-0987(97)00270-4","article-title":"Nail penetration of the antifungal agent oxiconazole after repeated topical application in healthy volunteers, and the effect of acetylcysteine","volume":"5","author":"van Hoogdalem","year":"1997","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bmcl.2025.130143_bb0165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1021\/jm00383a012","article-title":"Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles","volume":"28","author":"Strupczewski","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2025.130143_bb0170","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3390\/molecules25102356","article-title":"Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors","volume":"25","author":"Oh","year":"2020","journal-title":"Molecules"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:30:25Z","timestamp":1777642225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25000526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":34,"alternative-id":["S0960894X25000526"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130143","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxime functionalized Chalcones: Unveiling a new class of Chalcones with potent Antiplasmodial activity against blood-stages of Plasmodium falciparum in culture","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130143"}}