{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:43:50Z","timestamp":1790696630344,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bmcl.2025.130151","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:13:42Z","timestamp":1740125622000},"page":"130151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A review-plant medicine and its extraction components inhibit influenza virus"],"prefix":"10.1016","volume":"120","author":[{"given":"Jiejie","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Herdewijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130151_bb0005","first-page":"751","article-title":"Influenza: diagnosis and treatment","volume":"100","author":"Gaitonde","year":"2019","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.bmcl.2025.130151_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8405","article-title":"Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity","volume":"10","author":"Koutsakos","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bmcl.2025.130151_bb0015","series-title":"Influenza Pandemics 2000 Years of pandemics: past, present, and future","first-page":"107","author":"Ferreira","year":"2023"},{"key":"10.1016\/j.bmcl.2025.130151_bb0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.coviro.2012.02.013","article-title":"Pathogenesis of influenza virus infections: the good, the bad and the ugly","volume":"2","author":"Kuiken","year":"2012","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/v9080223","article-title":"Influenza virus infection, interferon response, viral counter-response, and apoptosis","volume":"9","author":"Shim","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2025.130151_bb0030","doi-asserted-by":"crossref","first-page":"510","DOI":"10.47102\/annals-acadmedsg.V37N6p510","article-title":"Vaccines for pandemic influenza. The history of our current vaccines, their limitations and the requirements to deal with a pandemic threat","volume":"37","author":"Hampson","year":"2008","journal-title":"Ann Acad Med Singap"},{"key":"10.1016\/j.bmcl.2025.130151_bb0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00430-007-0052-3","article-title":"The threat of avian influenza a (H5N1). Part IV: development of vaccines","volume":"196","author":"Cinatl","year":"2007","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0040","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.vaccine.2014.03.019","article-title":"A model for early onset of protection against lethal challenge with highly pathogenic H5N1 influenza virus","volume":"32","author":"R\u00f6hrs","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.bmcl.2025.130151_bb0045","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1056\/NEJMp068030","article-title":"Antiviral resistance in influenza viruses\u2014implications for management and pandemic response","volume":"354","author":"Hayden","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2025.130151_bb0050","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.coviro.2011.09.002","article-title":"Antivirals and resistance: influenza virus","volume":"1","author":"Ison","year":"2011","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00430-007-0048-z","article-title":"The threat of avian influenza a (H5N1). Part III: antiviral therapy","volume":"196","author":"Cinatl","year":"2007","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29484","article-title":"A protectin DX (PDX) analog with in vitro activity against influenza a (H1N1) viruses","volume":"96","author":"Fortin","year":"2024","journal-title":"J Med Virol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/IDR.S105473","article-title":"Drug resistance in influenza a virus: the epidemiology and management","volume":"10","author":"Hussain","year":"2017","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.bmcl.2025.130151_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112584","article-title":"Liu Shen Wan inhibits influenza a virus and excessive virus-induced inflammatory response via suppression of TLR4\/NF-\u03baB signaling pathway in vitro and in vivo","volume":"252","author":"Ma","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0075","article-title":"Progress in traditional Chinese medicine against respiratory viruses: a review","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0080","first-page":"153","article-title":"Influenza a: understanding the viral life cycle","volume":"82","author":"Samji","year":"2009","journal-title":"The Yale Journal of Biology and Medicine"},{"key":"10.1016\/j.bmcl.2025.130151_bb0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(92)90452-I","article-title":"Influenza virus M2 protein has ion channel activity","volume":"69","author":"Pinto","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2025.130151_bb0090","series-title":"Interaction Study of Influenza RNA Polymerase Subunit PB2 and Nucleoprotein","author":"To WCS","year":"2021"},{"key":"10.1016\/j.bmcl.2025.130151_bb0095","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nrmicro2613","article-title":"Influenza a viruses: new research developments","volume":"9","author":"Medina","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0100","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nrmicro3362","article-title":"Enabling the\u2019host jump\u2019: structural determinants of receptor-binding specificity in influenza a viruses","volume":"12","author":"Shi","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0105","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2353\/ajpath.2008.070791","article-title":"Pathology, molecular biology, and pathogenesis of avian influenza a (H5N1) infection in humans","volume":"172","author":"Korteweg","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0110","first-page":"16","article-title":"Plants: An alternative source for antimicrobials","author":"Abdallah","year":"2011","journal-title":"Journal of applied pharmaceutical Science"},{"issue":"1363\u20131369","key":"10.1016\/j.bmcl.2025.130151_bb0115","article-title":"The evolutionary potential of influenza a virus hemagglutinin is highly constrained by epistatic interactions with neuraminidase","volume":"30","author":"Liu","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bmcl.2025.130151_bb0120","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.fshw.2021.12.008","article-title":"Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases","volume":"11","author":"Truong","year":"2022","journal-title":"Food Sci Human Wellness"},{"key":"10.1016\/j.bmcl.2025.130151_bb0125","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0166-3542(93)90008-7","article-title":"Inhibition of the infectivity of influenza virus by tea polyphenols","volume":"21","author":"Nakayama","year":"1993","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0130","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.3390\/plants11223036","article-title":"Chaenomeles species\u2014characteristics of plant, fruit and processed products: a review","volume":"11","author":"Marat","year":"2022","journal-title":"Plants"},{"key":"10.1016\/j.bmcl.2025.130151_bb0135","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2008.03.013","article-title":"Anti-influenza virus activity of Chaenomeles sinensis","volume":"118","author":"Sawai","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0140","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1099\/jgv.0.000535","article-title":"Filamentous influenza viruses","volume":"97","author":"Dadonaite","year":"2016","journal-title":"J Gen Virol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0145","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tim.2014.01.010","article-title":"Bat-derived influenza-like viruses H17N10 and H18N11","volume":"22","author":"Wu","year":"2014","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154465","article-title":"Puerarin: a review of its mechanisms of action and clinical studies in ophthalmology","volume":"107","author":"Meng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bmcl.2025.130151_bb0155","doi-asserted-by":"crossref","unstructured":"Wang HX, Zeng MS, Ye Y, Liu JY, Xu PP. Antiviral activity of puerarin as potent inhibitor of influenza virus neuraminidase. Phytother Res 2021;35:324\u2013336.","DOI":"10.1002\/ptr.6803"},{"key":"10.1016\/j.bmcl.2025.130151_bb0160","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fmicb.2020.00182","article-title":"Identification of chebulinic acid and chebulagic acid as novel influenza viral neuraminidase inhibitors","volume":"11","author":"Li","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0165","first-page":"375","article-title":"Antiviral activity of plant-derived natural products against influenza viruses","volume":"32","author":"Kim","year":"2022","journal-title":"J Life Sci"},{"key":"10.1016\/j.bmcl.2025.130151_bb0170","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1038\/s41598-023-31946-5","article-title":"Study of the distribution of Glycyrrhiza uralensis production areas as well as the factors affecting yield and quality","volume":"13","author":"Cui","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2025.130151_bb0175","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2009.12.106","article-title":"Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis","volume":"20","author":"Ryu","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130151_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112945","article-title":"Antiviral activity of furanocoumarins isolated from Angelica dahurica against influenza a viruses H1N1 and H9N2","volume":"259","author":"Lee","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0185","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0190","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.antiviral.2013.08.002","article-title":"Inhibition of influenza virus internalization by (\u2212)-epigallocatechin-3-gallate","volume":"100","author":"Kim","year":"2013","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0195","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"Song","year":"2005","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0200","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.foodchem.2009.09.011","article-title":"Curcumin inhibits influenza virus infection and haemagglutination activity","volume":"119","author":"Chen","year":"2010","journal-title":"Food Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12272-020-01230-5","article-title":"3D-quantitative structure\u2013activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase","volume":"43","author":"Lai","year":"2020","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fcell.2020.00479","article-title":"The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0215","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jep.2014.05.035","article-title":"Anti-influenza virus activity of the ethanolic extract from Peperomia sui","volume":"155","author":"Yang","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0220","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/ncomms2589","article-title":"The role and assembly mechanism of nucleoprotein in influenza a virus ribonucleoprotein complexes","volume":"4","author":"Turrell","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2025.130151_bb0225","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1021\/acs.analchem.1c05387","article-title":"Uncovering the F-actin-based nuclear egress mechanism of newly synthesized influenza a virus ribonucleoprotein complexes by single-particle tracking","volume":"94","author":"Yu","year":"2022","journal-title":"Anal Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0230","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1080\/22221751.2020.1812436","article-title":"Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice","volume":"9","author":"Yin","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.bmcl.2025.130151_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-8-538","article-title":"Anti-influenza virus effect of aqueous extracts from dandelion","volume":"8","author":"He","year":"2011","journal-title":"Virol J"},{"key":"10.1016\/j.bmcl.2025.130151_bb0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1142\/S1682648515500018","article-title":"In vitro anti-viral activity of ethanol extract from Ixeris Chinensis against influenza virus","volume":"41","author":"Yang","year":"2015","journal-title":"Taiwan Veterinary J"},{"key":"10.1016\/j.bmcl.2025.130151_bb0245","series-title":"Potential of Dendrobium spp. Secondary Metabolites as Medicinal Source for SARS-CoV-2","author":"Rafli","year":"2022"},{"key":"10.1016\/j.bmcl.2025.130151_bb0250","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1021\/acs.jafc.7b00276","article-title":"Anti-influenza a virus activity of dendrobine and its mechanism of action","volume":"65","author":"Li","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.997","article-title":"Interaction among inflammasome, PANoptosise, and innate immune cells in infection of influenza virus: updated review","volume":"11","author":"Wei","year":"2023","journal-title":"Immunity, Inflammation and Disease"},{"key":"10.1016\/j.bmcl.2025.130151_bb0260","doi-asserted-by":"crossref","first-page":"9215","DOI":"10.1128\/JVI.00805-09","article-title":"Influenza virus directly infects human natural killer cells and induces cell apoptosis","volume":"83","author":"Mao","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0265","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00011-017-1109-4","article-title":"Inhibitory effects and related molecular mechanisms of total flavonoids in Mosla chinensis maxim against H1N1 influenza virus","volume":"67","author":"Zhang","year":"2018","journal-title":"Inflamm Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1602447","article-title":"Investigation of pharmacological mechanisms of yinhua pinggan granule on the treatment of pneumonia through network pharmacology and in vitro","volume":"2022","author":"Jin","year":"2022","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bmcl.2025.130151_bb0275","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.intimp.2018.01.002","article-title":"Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4\/MyD88 pathway","volume":"56","author":"Cheng","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0280","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11095-009-0003-3","article-title":"Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cells","volume":"27","author":"Gao","year":"2010","journal-title":"Pharm Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0285","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.intimp.2012.07.007","article-title":"Kaempferol regulates MAPKs and NF-\u03baB signaling pathways to attenuate LPS-induced acute lung injury in mice","volume":"14","author":"Chen","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216299","article-title":"Kaempferol: a review of current evidence of its antiviral potential","volume":"24","author":"Periferakis","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2025.130151_bb0295","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1610751","article-title":"Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage","volume":"2018","author":"Du","year":"2018","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.bmcl.2025.130151_bb0300","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.3390\/agronomy12102582","article-title":"Comprehensive assessment of Houttuynia cordata Thunb., an important medicinal plant and vegetable","volume":"12","author":"Luo","year":"2022","journal-title":"Agronomy"},{"key":"10.1016\/j.bmcl.2025.130151_bb0305","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ptr.1892","article-title":"Anti-influenza agents from plants and traditional Chinese medicine","volume":"20","author":"Wang","year":"2006","journal-title":"Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives"},{"key":"10.1016\/j.bmcl.2025.130151_bb0310","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1523\/JNEUROSCI.1066-19.2019","article-title":"Autophagy in myelinating glia","volume":"40","author":"Belgrad","year":"2020","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmcl.2025.130151_bb0315","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/cmi.2010.25","article-title":"Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction","volume":"7","author":"Law","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0320","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coi.2008.01.001","article-title":"Autophagy and antiviral immunity","volume":"20","author":"Lee","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0325","article-title":"Pharmacological effects of baicalin in lung diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0330","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.antiviral.2014.11.003","article-title":"Baicalin inhibits autophagy induced by influenza a virus H3N2","volume":"113","author":"Zhu","year":"2015","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0335","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1389200223666220202090137","article-title":"Distribution, biotransformation, pharmacological effects, metabolic mechanism and safety evaluation of Platycodin D: a comprehensive review","volume":"23","author":"Li","year":"2022","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.bmcl.2025.130151_bb0340","article-title":"Study on the inhibition of PLD on IAV-induced pulmonary macrophage based on autophagy and apoptosis","volume":"16","author":"Li","year":"2020","journal-title":"Pharmacogn Mag"},{"key":"10.1016\/j.bmcl.2025.130151_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109471","article-title":"Gegen qinlian decoction downregulates the TLR7 signalling pathway to control influenza a virus infection","volume":"121","author":"Shi","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmcl.2025.130151_bb0350","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/v13071362","article-title":"The mechanism behind influenza virus cytokine storm","volume":"13","author":"Gu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2025.130151_bb0355","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10787-019-00633-1","article-title":"Polygalasaponin F treats mice with pneumonia induced by influenza virus","volume":"28","author":"Ye","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bmcl.2025.130151_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1585-7","article-title":"The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function","volume":"17","author":"Ding","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.bmcl.2025.130151_bb0365","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tifs.2020.08.006","article-title":"Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: a systematic update of pre-clinical and clinical data","volume":"104","author":"Rouf","year":"2020","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0370","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s13318-018-0509-3","article-title":"Pharmacokinetics and bioavailability enhancement of baicalin: a review","volume":"44","author":"Huang","year":"2019","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.bmcl.2025.130151_bb0375","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3892\/br.2014.253","article-title":"Baicalin inhibits TLR7\/MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza a virus","volume":"2","author":"Wan","year":"2014","journal-title":"Biomed Rep"},{"key":"10.1016\/j.bmcl.2025.130151_bb0380","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.3390\/molecules26185583","article-title":"A review on preparation of betulinic acid and its biological activities","volume":"26","author":"Lou","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130151_bb0385","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4062\/biomolther.2015.019","article-title":"Anti-influenza activity of betulinic acid from Zizyphus jujuba on influenza a\/PR\/8 virus","volume":"23","author":"Hong","year":"2015","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.bmcl.2025.130151_bb0390","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.celrep.2018.03.045","article-title":"Genome-wide CRISPR\/Cas9 screen identifies host factors essential for influenza virus replication","volume":"23","author":"Han","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmcl.2025.130151_bb0395","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0975-8844.106202","article-title":"Superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia, and oral cancer: a comparative study","volume":"4","author":"Gurudath","year":"2012","journal-title":"Journal of Orofacial Sciences"},{"key":"10.1016\/j.bmcl.2025.130151_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43094-020-00161-8","article-title":"Flavonoids as natural phenolic compounds and their role in therapeutics: An overview","volume":"7","author":"Mutha","year":"2021","journal-title":"Futur J Pharm Sci"},{"key":"10.1016\/j.bmcl.2025.130151_bb0405","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.foodchem.2016.09.018","article-title":"Free radical scavenging potency of quercetin catecholic colonic metabolites: thermodynamics of 2H+\/2e\u2212 processes","volume":"218","author":"Ami\u0107","year":"2017","journal-title":"Food Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0410","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1021\/acs.jafc.6b01056","article-title":"Potential of excipient emulsions for improving quercetin bioaccessibility and antioxidant activity: an in vitro study","volume":"64","author":"Chen","year":"2016","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0415","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.foodchem.2010.01.033","article-title":"Flavonoid content and antioxidant activity of vegetables from Indonesia","volume":"121","author":"Andarwulan","year":"2010","journal-title":"Food Chem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0420","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2613.2003.00344.x","article-title":"Effect of quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection","volume":"84","author":"Kumar","year":"2003","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0425","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/molecules28010281","article-title":"Protective effects of ferulic acid on metabolic syndrome: a comprehensive review","volume":"28","author":"Ye","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130151_bb0430","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fct.2013.12.024","article-title":"Ferulic acid: pharmacological and toxicological aspects","volume":"65","author":"Mancuso","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0435","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000491755","article-title":"Antioxidant properties of ferulic acid and its possible application","volume":"31","author":"Zdu\u0144ska","year":"2018","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0440","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1142\/S0192415X15500391","article-title":"Beneficial effects of Polygonum multiflorum on hippocampal neuronal cells and mouse focal cerebral ischemia","volume":"43","author":"Ahn","year":"2015","journal-title":"The American Journal of Chinese Medicine"},{"key":"10.1016\/j.bmcl.2025.130151_bb0445","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1159\/000373971","article-title":"Emodin protects against concanavalin A-induced hepatitis in mice through inhibiting activation of the p38 MAPK-NF-\u03baB signaling pathway","volume":"35","author":"Xue","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bmcl.2025.130151_bb0450","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.3748\/wjg.v21.i10.2937","article-title":"Heme oxygenase-1 protects rat liver against warm ischemia\/reperfusion injury via TLR2\/TLR4-triggered signaling pathways","volume":"21","author":"Huang","year":"2015","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.bmcl.2025.130151_bb0455","article-title":"Anti-influenza a virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-\u03baB signal pathways","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2025.130151_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105465","article-title":"In vitro and in vivo effects of 3-indoleacetonitrile\u2014a potential new broad-spectrum therapeutic agent for SARS-CoV-2 infection","volume":"209","author":"Hui","year":"2023","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0465","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3390\/v13081433","article-title":"3-Indoleacetonitrile is highly effective in treating influenza a virus infection in vitro and in vivo","volume":"13","author":"Zhao","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2025.130151_bb0470","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s12275-018-8222-0","article-title":"Antiviral activity of Poncirus trifoliata seed extract against oseltamivir-resistant influenza virus","volume":"56","author":"Heo","year":"2018","journal-title":"J Microbiol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0475","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-008-1145-7","article-title":"Bioactivity of Flavonoid Compounds from Poncirus trifoliata L.(Family: Rutaceae) against the Dengue Vector, Aedes aegypti L. (Diptera: Culicidae)","volume":"Vol. 104","author":"Rajkumar","year":"2008","journal-title":"Parasitol Res"},{"key":"10.1016\/j.bmcl.2025.130151_bb0480","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/molecules28010041","article-title":"Antiviral activities of ethyl pheophorbides a and b isolated from Aster pseudoglehnii against influenza viruses","volume":"28","author":"Park","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130151_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153892","article-title":"Potent antiviral activity of the extract of Elaeocarpus sylvestris against influenza a virus in vitro and in vivo","volume":"97","author":"Joo","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bmcl.2025.130151_bb0490","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tifs.2015.04.010","article-title":"Perspectives on geraniin, a multifunctional natural bioactive compound","volume":"44","author":"Perera","year":"2015","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.bmcl.2025.130151_bb0495","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.proenv.2015.07.089","article-title":"Antioxidant active compounds from elaeocarpussylvestris and their relationship between structure and activity","volume":"28","author":"Prihantini","year":"2015","journal-title":"Procedia Environ Sci"},{"key":"10.1016\/j.bmcl.2025.130151_bb0500","first-page":"1503","article-title":"Studies on chemical constituents from Elaeocarpus sylvestris","volume":"31","author":"Zhang","year":"2008","journal-title":"J Chin Med Mater"},{"key":"10.1016\/j.bmcl.2025.130151_bb0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1941-7","article-title":"Inhibition of human cytomegalovirus immediate-early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro","volume":"17","author":"Bae","year":"2017","journal-title":"BMC Complement Altern Med"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T09:05:33Z","timestamp":1741511133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":101,"alternative-id":["S0960894X25000605"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130151","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review-plant medicine and its extraction components inhibit influenza virus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130151"}}