{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:09:08Z","timestamp":1781212148715,"version":"3.54.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["FRGS\/1\/2023\/STG04\/UNIKL\/02\/2"],"award-info":[{"award-number":["FRGS\/1\/2023\/STG04\/UNIKL\/02\/2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bmcl.2025.130232","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T20:08:18Z","timestamp":1744142898000},"page":"130232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Discovery of New Non-Symmetrical Heterocyclic Pentanoid Derivatives Targeting Metastatic Triple-Negative Breast Cancer"],"prefix":"10.1016","volume":"123","author":[{"given":"Poh Yen","family":"Khor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson","family":"Stanslas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurulfazlina Edayah","family":"Rasol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Meng","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phooi Yan","family":"Mock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Wai","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bmcl.2025.130232_bb0005","first-page":"1","article-title":"How many diseases is triple negative breast cancer\u00a0: the protagonism of the immune microenvironment","volume":"2","author":"Saraiva","year":"2017","journal-title":"EMSO Open"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130232_bb0010","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3322\/caac.21583","article-title":"Breast cancer statistics, 2019","volume":"69","author":"DeSantis","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130232_bb0015","first-page":"1","article-title":"Targeting c-MYC G-Quadruplexes for Cancer treatment with small molecules","volume":"93","author":"Thumpati","year":"2025","journal-title":"Sci Pharm"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130232_bb0020","first-page":"1","article-title":"Combating multidrug-resistance in S. Pneumoniae\u00a0: a G-quadruplex binding inhibitor of efflux pump and its bio-orthogonal assembly. NAR","volume":"1","author":"Chaudhuri","year":"2024","journal-title":"Mol Med"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130232_bb0025","article-title":"Repurposing proteasome inhibitors for improved treatment of triple-negative breast cancer","volume":"10","author":"Larsson","year":"2024","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130232_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-43121-x","article-title":"Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer","volume":"13","author":"Byers","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130232_bb0035","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.chembiol.2016.12.016","article-title":"Inhibition of the proteasome \u03b22 site sensitizes triple-negative breast Cancer cells to \u03b25 inhibitors and suppresses Nrf1 activation","volume":"24","author":"Weyburne","year":"2017","journal-title":"Cell Chem Biol"},{"issue":"Supplement 1","key":"10.1016\/j.bmcl.2025.130232_bb0040","article-title":"Targeting ER stress by the combination of proteasome inhibitors and HIV protease inhibitors in preclinical models of triple-negative breast Cancer","volume":"25","author":"Marsico","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bmcl.2025.130232_bb0045","series-title":"Small Molecules that Block Proteasome-Associated Ubiquitin Receptor RPN13 Function and Uses thereof","first-page":"1","author":"Qi","year":"2023"},{"key":"10.1016\/j.bmcl.2025.130232_bb0050","first-page":"1","author":"Kalid","year":"2020","journal-title":"Compounds for Inhibiting Protein Degradation and Method of use thereof in the Treatment of Cancer"},{"key":"10.1016\/j.bmcl.2025.130232_bb0055","series-title":"Bis-benzylidine Piperidone Proteasome Inhibitor with Anticancer Activity","first-page":"1","author":"Roden","year":"2019"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130232_bb0060","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13738-018-1498-5","article-title":"Green synthesis of dissymmetric bisarylidene derivatives of cyclohexanone analogues under ultrasonic conditions","volume":"16","author":"Mojtahedi","year":"2018","journal-title":"J Iran Chem Soc"},{"issue":"11","key":"10.1016\/j.bmcl.2025.130232_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10111507","article-title":"Proteasome inhibitor mg132 is toxic and inhibits the proliferation of rat neural stem cells but increases bdnf expression to protect neurons","volume":"10","author":"Kim","year":"2020","journal-title":"Biomolecules"},{"issue":"29","key":"10.1016\/j.bmcl.2025.130232_bb0070","first-page":"1","article-title":"Targeting the ubiquitin \u2013 proteasome system and recent advances in Cancer therapy","volume":"13","author":"Spano","year":"2024","journal-title":"Cells"},{"issue":"5754","key":"10.1016\/j.bmcl.2025.130232_bb0075","first-page":"1","article-title":"The involvement of ubiquitination machinery in cell cycle regulation and Cancer progression","volume":"22","author":"Zou","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25001416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25001416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T21:02:22Z","timestamp":1745528542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25001416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":15,"alternative-id":["S0960894X25001416"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130232","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of New Non-Symmetrical Heterocyclic Pentanoid Derivatives Targeting Metastatic Triple-Negative Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130232"}}