{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:47:19Z","timestamp":1776919639371,"version":"3.51.2"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"am","delay-in-days":253,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI155664"],"award-info":[{"award-number":["R01 AI155664"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bmcl.2025.130359","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:53:27Z","timestamp":1754495607000},"page":"130359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synthesis and antibacterial activity of novel benzodioxin-containing oxazolidinones against M. abscessus"],"prefix":"10.1016","volume":"128","author":[{"given":"Connor M.","family":"Winkelhake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binayak","family":"Rimal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe B.","family":"Huisken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyanu","family":"Lamichhane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Thomas","family":"Ippoliti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bmcl.2025.130359_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ja.2017.62","article-title":"A brief history of antibiotics and select advances in their synthesis","volume":"71","author":"Nicolaou","year":"2018","journal-title":"J Antibiot (Tokyo)"},{"issue":"20","key":"10.1016\/j.bmcl.2025.130359_bb0010","doi-asserted-by":"crossref","first-page":"13860","DOI":"10.1021\/acs.jmedchem.3c01040","article-title":"Strategies for the discovery of oxazolidinone antibacterial agents: development and future perspectives","volume":"66","author":"Liu","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130359_bb0015","unstructured":"Fugitt R. 5-Halomethyl-3-Phenyl-2-Oxazolidinones. US Patent 4128654. 1978."},{"issue":"7","key":"10.1016\/j.bmcl.2025.130359_bb0020","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/jm800038g","article-title":"Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious Gram-positive infections","volume":"51","author":"Brickner","year":"2008","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130359_bb0025","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1021\/jm00128a003","article-title":"Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The B group","volume":"32","author":"Gregory","year":"1989","journal-title":"J Med Chem"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130359_bb0030","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/AAC.42.12.3251","article-title":"The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria","volume":"42","author":"Swaney","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130359_bb0035","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-biochem-062917-011942","article-title":"Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design","volume":"87","author":"Lin","year":"2018","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130359_bb0040","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10409230500326334","article-title":"The ribosomal peptidyl transferase center: structure, function, evolution, inhibition","volume":"40","author":"Polacek","year":"2005","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130359_bb0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41594-022-00723-9","article-title":"Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics","volume":"29","author":"Tsai","year":"2022","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130359_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf046","article-title":"Context-specific inhibition of mitochondrial ribosomes by phenicol and oxazolidinone antibiotics","volume":"53","author":"Bibel","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130359_bb0055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/acsptsci.0c00041","article-title":"Characterization of the core ribosomal binding region for the oxazolidone family of antibiotics using Cryo-EM","volume":"3","author":"Wright","year":"2020","journal-title":"ACS Pharmacol Transl Sci"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130359_bb0060","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1021\/jm800379d","article-title":"Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit","volume":"51","author":"Ippolito","year":"2008","journal-title":"J Med Chem"},{"issue":"43","key":"10.1016\/j.bmcl.2025.130359_bb0065","doi-asserted-by":"crossref","first-page":"E5805","DOI":"10.1073\/pnas.1517952112","article-title":"Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus","volume":"112","author":"Eyal","year":"2015","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130359_bb0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/antibiotics12030463","article-title":"Comparative assessment of docking programs for docking and virtual screening of ribosomal oxazolidinone antibacterial agents","volume":"12","author":"Buckley","year":"2023","journal-title":"Antibiotics"},{"issue":"14","key":"10.1016\/j.bmcl.2025.130359_bb0075","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/jm100112j","article-title":"A medicinal chemist\u2019s guide to molecular interactions","volume":"53","author":"Bissantz","year":"2010","journal-title":"J Med Chem"},{"issue":"11","key":"10.1016\/j.bmcl.2025.130359_bb0080","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00889-21","article-title":"A novel oxazolidinone, contezolid (MRX-I), expresses anti-Mycobacterium abscessus activity in vitro","volume":"65","author":"Guo","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130359_bb0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s40262-017-0601-x","article-title":"Clinical pharmacokinetics and pharmacodynamics of oxazolidinones","volume":"57","author":"Roger","year":"2018","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130359_bb0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccm.2021.11.007","article-title":"Nontuberculous mycobacteria","volume":"43","author":"Varley","year":"2022","journal-title":"Clin Chest Med"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130359_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chest.2021.07.035","article-title":"Treatment of Mycobacterium abscessus pulmonary disease","volume":"161","author":"Griffith","year":"2022","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130359_bb0100","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41579-020-0331-1","article-title":"Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus","volume":"18","author":"Johansen","year":"2020","journal-title":"Nat Rev Microbiol"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130359_bb0105","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1513\/AnnalsATS.202009-1214OC","article-title":"Population genomics of Mycobacterium abscessus from U.S. cystic fibrosis care centers","volume":"18","author":"Davidson","year":"2021","journal-title":"Ann Am Thorac Soc"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130359_bb0110","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciaa241","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"suppl 2","key":"10.1016\/j.bmcl.2025.130359_bb0115","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2017-210927","article-title":"British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)","volume":"72","author":"Haworth","year":"2017","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130359_bb0120","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat Rev Microbiol."},{"issue":"3","key":"10.1016\/j.bmcl.2025.130359_bb0125","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/microorganisms7030090","article-title":"Mycobacterium abscessus: environmental bacterium turned clinical nightmare","volume":"7","author":"Lopeman","year":"2019","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130359_bb0130","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.drudis.2018.04.001","article-title":"NTM drug discovery: status, gaps and the way forward","volume":"23","author":"Wu","year":"2018","journal-title":"Drug Discov Today"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130359_bb0135","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.bmc.2007.11.040","article-title":"Synthesis of novel oxazolidinone antimicrobial agents","volume":"16","author":"Ebner","year":"2008","journal-title":"Bioorg Med Chem"},{"issue":"15","key":"10.1016\/j.bmcl.2025.130359_bb0140","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1016\/j.bmcl.2016.06.019","article-title":"An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and Gram positive bacteria","volume":"26","author":"Kaushik","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130359_bb0145","series-title":"Oxazolidinones and Pharmaceutical Compositions Thereof for Treating Bacterial Infections, Including Infection of Mycobacterium Tuberculosis","author":"Ippoliti","year":"2020"},{"key":"10.1016\/j.bmcl.2025.130359_bb0150","series-title":"Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis","author":"Lamichhane","year":"2024"},{"key":"10.1016\/j.bmcl.2025.130359_bb0155","first-page":"43","article-title":"Successful use of linezolid for refractory Mycobacterium abcessus infection: a case report","volume":"23","author":"Inoue","year":"2018","journal-title":"Respir Med Case Rep"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130359_bb0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12941-023-00655-2","article-title":"Effectiveness and safety of regimens containing linezolid for treatment of Mycobacterium abscessus pulmonary disease","volume":"22","author":"Cheng","year":"2023","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.bmcl.2025.130359_bb0165","series-title":"Greene\u2019s Protective Groups in Organic Synthesis","author":"Wuts","year":"2014"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130359_bb0170","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/op034028h","article-title":"The synthesis of N-aryl-5(S)-aminomethyl-2-oxazolidinone antibacterials and derivatives in one step from aryl carbamates","volume":"7","author":"Perrault","year":"2003","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmcl.2025.130359_bb0175","series-title":"M24 Suppl.","article-title":"Performance standards for susceptibility testing of Mycobacteria, Nocardia spp., and other Aerobic Actinomycetes","author":"CLSI","year":"2018"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130359_bb0180","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/acs.joc.1c01431","article-title":"Metal-free, rapid, and highly chemoselective reduction of aromatic nitro compounds at room temperature","volume":"87","author":"Jang","year":"2022","journal-title":"J Org Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25002689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25002689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:20:50Z","timestamp":1776918050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25002689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":36,"alternative-id":["S0960894X25002689"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130359","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antibacterial activity of novel benzodioxin-containing oxazolidinones against M. abscessus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130359"}}