{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:03:55Z","timestamp":1785171835556,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bmcl.2025.130393","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:46:12Z","timestamp":1756856772000},"page":"130393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting virulence to disarm the pathogen: Enzyme-activated-substrate inhibition of Anthrax edema factor"],"prefix":"10.1016","volume":"129","author":[{"given":"Seongjin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Cregar-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Moayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"329","key":"10.1016\/j.bmcl.2025.130393_bb0005","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad9922","article-title":"Staphylococcus aureus alpha toxin potentiates opportunistic bacterial lung infections","volume":"8","author":"Cohen","year":"2016","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130393_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130393_bb0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","article-title":"Targeting virulence: a new paradigm for antimicrobial therapy","volume":"3","author":"Clatworthy","year":"2007","journal-title":"Nat Chem Biol"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130393_bb0020","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mib.2009.06.012","article-title":"Productive steps toward an antimicrobial targeting virulence","volume":"12","author":"Barczak","year":"2009","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130393_bb0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/emph\/eow012","article-title":"Beyond killing: can we find new ways to manage infection?","volume":"2016","author":"Vale","year":"2016","journal-title":"Evol Med Public Health"},{"key":"10.1016\/j.bmcl.2025.130393_bb0030","series-title":"Bacterial Pathogens and their Virulence Factors","author":"Johnson","year":"2018"},{"issue":"10","key":"10.1016\/j.bmcl.2025.130393_bb0035","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1371\/journal.ppat.0030147","article-title":"Pathogenesis, virulence, and infective dose","volume":"3","author":"Schmid-Hempel","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmcl.2025.130393_bb0040","unstructured":"Department of Homeland Security-National Planning Scenarios, 2006, Scenario 2: biological attack-aerosol Anthrax. https:\/publicintelligence.net\/national-planning-scenarios\/."},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0045","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.mam.2009.06.002","article-title":"Anthrax toxins: a weapon to systematically dismantle the host immune defenses","volume":"30","author":"Tournier","year":"2009","journal-title":"Mol Asp Med"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130393_bb0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chom.2010.10.004","article-title":"Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of bacillus anthracis infections in mice","volume":"8","author":"Liu","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0055","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.ajpath.2011.02.027","article-title":"Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax","volume":"178","author":"Dumetz","year":"2011","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.bmcl.2025.130393_bb0060","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","article-title":"Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells","volume":"79","author":"Leppla","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2025.130393_bb0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-micro-091014-104523","article-title":"Anthrax pathogenesis","volume":"69","author":"Moayeri","year":"2015","journal-title":"Ann Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130393_bb0070","first-page":"3","article-title":"Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin","author":"Lawrence","year":"2011","journal-title":"Toxins (Basel)"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0075","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid0706.010604","article-title":"Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States","volume":"7","author":"Jernigan","year":"2001","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130393_bb0080","doi-asserted-by":"crossref","first-page":"H238","DOI":"10.1152\/ajpheart.00185.2013","article-title":"Anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model","volume":"305","author":"Li","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7465","key":"10.1016\/j.bmcl.2025.130393_bb0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature12510","article-title":"Key tissue targets responsible for anthrax-toxin-induced lethality","volume":"501","author":"Liu","year":"2013","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130393_bb0090","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.celrep.2013.10.019","article-title":"Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin","volume":"5","author":"Abrami","year":"2013","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130393_bb0095","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1086\/512372","article-title":"A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor","volume":"44","author":"Walsh","year":"2007","journal-title":"Clinical infectious diseases\u202f: an official publication of the Infectious Diseases Society of America"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130393_bb0100","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7326\/0003-4819-144-4-200602210-00009","article-title":"Systematic review: a century of inhalational anthrax cases from 1900 to 2005","volume":"144","author":"Holty","year":"2006","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130393_bb0105","first-page":"1","article-title":"Centers for Disease, C.; Prevention, Clinical framework and medical countermeasure use during an Anthrax mass-casualty incident. MMWR. Recommendations and reports\u202f: morbidity and mortality weekly report. Recommendations and reports \/ centers for disease","volume":"64","author":"Bower","year":"2015","journal-title":"Control"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0110","first-page":"1","article-title":"CDC guidelines for the prevention and treatment of Anthrax, 2023. MMWR. Recommendations and reports\u202f: morbidity and mortality weekly report","volume":"72","author":"Bower","year":"2023","journal-title":"Recommendations and reports \/ centers for disease Control"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130393_bb0115","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1056\/NEJMcpc1003887","article-title":"Case records of the Massachusetts General Hospital. Case 25-2010. A 24-year-old woman with abdominal pain and shock","volume":"363","author":"Klempner","year":"2010","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130393_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-13-408","article-title":"Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users","volume":"13","author":"Russell","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0125","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.bmcl.2012.01.095","article-title":"Antidotes to anthrax lethal factor intoxication. Part 3: evaluation of core structures and further modifications to the C2-side chain","volume":"22","author":"Jiao","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130393_bb0130","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1128\/AAC.00941-13","article-title":"Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection","volume":"57","author":"Moayeri","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"10.1016\/j.bmcl.2025.130393_bb0135","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3390\/toxins4111288","article-title":"Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor","volume":"4","author":"Schein","year":"2012","journal-title":"Toxins (Basel)"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130393_bb0140","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pharmthera.2013.07.002","article-title":"Inhibitors of bacillus anthracis edema factor","volume":"140","author":"Seifert","year":"2013","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130393_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202100568","article-title":"Halogen-dance-based synthesis of Phosphonomethoxyethyl (PME) substituted 2-Aminothiazoles as potent inhibitors of bacterial adenylate Cyclases","volume":"17","author":"\u010cesnek","year":"2022","journal-title":"ChemMedChem"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130393_bb0150","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0306552101","article-title":"Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection","volume":"101","author":"Shen","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"10.1016\/j.bmcl.2025.130393_bb0155","doi-asserted-by":"crossref","first-page":"11277","DOI":"10.1073\/pnas.0914611107","article-title":"Use of allostery to identify inhibitors of calmodulin-induced activation of bacillus anthracis edema factor","volume":"107","author":"Laine","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"28","key":"10.1016\/j.bmcl.2025.130393_bb0160","doi-asserted-by":"crossref","first-page":"29427","DOI":"10.1074\/jbc.M402689200","article-title":"Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate","volume":"279","author":"Guo","year":"2004","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130393_bb0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrd3955","article-title":"Adenosine receptors as drug targets - what are the challenges?","volume":"12","author":"Chen","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"48","key":"10.1016\/j.bmcl.2025.130393_bb0170","doi-asserted-by":"crossref","first-page":"15200","DOI":"10.1002\/anie.201707630","article-title":"Lysine-Targeting Covalent Inhibitors","volume":"56","author":"Pettinger","year":"2017","journal-title":"Angew Chem Int Ed Eng"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130393_bb0175","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/bi0024714","article-title":"The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50","volume":"40","author":"Czerwinski","year":"2001","journal-title":"Biochemistry"},{"issue":"51","key":"10.1016\/j.bmcl.2025.130393_bb0180","doi-asserted-by":"crossref","first-page":"10236","DOI":"10.1021\/bi301224b","article-title":"Magnesium-induced nucleophile activation in the guanylyltransferase mRNA capping enzyme","volume":"51","author":"Swift","year":"2012","journal-title":"Biochemistry"},{"issue":"13","key":"10.1016\/j.bmcl.2025.130393_bb0185","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1073\/pnas.1010750108","article-title":"Large shifts in pKa values of lysine residues buried inside a protein","volume":"108","author":"Isom","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130393_bb0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bmcl.2017.11.040","article-title":"Small molecule inhibitors of anthrax edema factor","volume":"28","author":"Jiao","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"issue":"23","key":"10.1016\/j.bmcl.2025.130393_bb0195","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1021\/jacs.6b02960","article-title":"Arylfluorosulfates inactivate intracellular lipid binding protein(s) through Chemoselective SuFEx reaction with a binding site Tyr residue","volume":"138","author":"Chen","year":"2016","journal-title":"J Am Chem Soc"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130393_bb0200","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1021\/acs.jmedchem.8b01153","article-title":"Emerging and re-emerging warheads for targeted covalent inhibitors: applications in medicinal chemistry and chemical biology","volume":"62","author":"Gehringer","year":"2019","journal-title":"J Med Chem"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130393_bb0205","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.chembiol.2015.07.018","article-title":"Identification and characterization of an irreversible inhibitor of CDK2","volume":"22","author":"Anscombe","year":"2015","journal-title":"Chem Biol"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130393_bb0210","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/sj.emboj.7600574","article-title":"Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor","volume":"24","author":"Shen","year":"2005","journal-title":"EMBO J"},{"issue":"6870","key":"10.1016\/j.bmcl.2025.130393_bb0215","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","article-title":"Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"issue":"52","key":"10.1016\/j.bmcl.2025.130393_bb0220","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1021\/acs.biochem.9b00293","article-title":"New electrophiles and strategies for mechanism-based and targeted covalent inhibitor design","volume":"58","author":"Ray","year":"2019","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130393_bb0225","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1124\/pr.107.07110","article-title":"Sortase as a target of anti-infective therapy","volume":"60","author":"Maresso","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmcl.2025.130393_bb0230","series-title":"Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists","author":"Copeland","year":"2005"},{"issue":"14","key":"10.1016\/j.bmcl.2025.130393_bb0235","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1021\/ja00404a043","article-title":"Active-site-directed inhibition of .alpha.-chymotrypsin by deaminatively produced carbonium ions: an example of suicide or enzyme-activated-substrate inhibition","volume":"103","author":"White","year":"1981","journal-title":"J Am Chem Soc"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130393_bb0240","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00210-011-0688-9","article-title":"Inhibition of the adenylyl cyclase toxin, edema factor, from bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5\u2032-triphosphates","volume":"385","author":"Taha","year":"2012","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.bmcl.2025.130393_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113581","article-title":"Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases","volume":"222","author":"B\u0159ehov\u00e1","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130393_bb0250","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1128\/IAI.00017-14","article-title":"Vibrio vulnificus biotype 3 multifunctional autoprocessing RTX toxin is an adenylate cyclase toxin essential for virulence in mice","volume":"82","author":"Ziolo","year":"2014","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.bmcl.2025.130393_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060369","article-title":"Structural biology and molecular modeling to analyze the entry of bacterial toxins and virulence factors into host cells","volume":"11","author":"Pitard","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130393_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126743","article-title":"Bacterial Nucleotidyl Cyclases activated by calmodulin or actin in host cells: enzyme specificities and cytotoxicity mechanisms identified to date","volume":"23","author":"Teixeira-Nunes","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:17:05Z","timestamp":1785169025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25003026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"alternative-id":["S0960894X25003026"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130393","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting virulence to disarm the pathogen: Enzyme-activated-substrate inhibition of Anthrax edema factor","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130393","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130393"}}