{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:43:53Z","timestamp":1788983033911,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010110","name":"Hebei University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmcl.2025.130415","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:40:55Z","timestamp":1758588055000},"page":"130415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis, and biological evaluation of novel potent dual Mer\/c-Met inhibitors based on structural optimization"],"prefix":"10.1016","volume":"130","author":[{"given":"Lihong","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daowei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130415_bb0005","first-page":"301","article-title":"Chapter nineteen - Mer receptor tyrosine kinase: therapeutic opportunities in oncology, virology, and cardiovascular indications","volume":"49","author":"Wang","year":"2014","journal-title":"Annu Rep Med Chem"},{"key":"10.1016\/j.bmcl.2025.130415_bb0010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrc3847","article-title":"The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer","volume":"14","author":"Graham","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmcl.2025.130415_bb0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12943-019-1057-4","article-title":"Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity","volume":"18","author":"Yu","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.bmcl.2025.130415_bb0020","doi-asserted-by":"crossref","first-page":"1244170","DOI":"10.3389\/fimmu.2023.1244170","article-title":"Structure and functions of Mer, an innate immune checkpoint","volume":"14","author":"Ubil","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130415_bb0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12964-023-01133-0","article-title":"Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis","volume":"21","author":"Gao","year":"2023","journal-title":"Cell Commun Signal"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130415_bb0030","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004863","article-title":"Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects","volume":"10","author":"Peters","year":"2022","journal-title":"J Immunother Cancer"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130415_bb0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/0192623317749469","article-title":"UNC569-induced morphological changes in pigment epithelia and photoreceptor cells in the retina through MerTK inhibition in mice","volume":"46","author":"Sayama","year":"2018","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.bmcl.2025.130415_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112942","article-title":"Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K\/Akt\/GSK-3\u03b2 pathway in gout","volume":"142","author":"Chen","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130415_bb0045","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1038\/s41467-024-49667-2","article-title":"Co-targeting JAK1\/STAT6\/GAS6\/TAM signaling improves chemotherapy efficacy in Ewing sarcoma","volume":"15","author":"Yu","year":"2024","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130415_bb0050","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1021\/acs.jmedchem.5c00009","article-title":"Discovery of novel TYRO3\/MERTK dual inhibitors","volume":"68","author":"Kong","year":"2025","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130415_bb0055","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jtho.2022.10.015","article-title":"MET alterations in NSCLC-current perspectives and future challenges","volume":"18","author":"Remon","year":"2023","journal-title":"J Thorac Oncol"},{"issue":"10","key":"10.1016\/j.bmcl.2025.130415_bb0060","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S1470-2045(24)00441-8","article-title":"Capmatinib in MET exon 14-mutated non-small-cell lung cancer: final results from the open-label, phase 2 GEOMETRY mono-1 trial","volume":"25","author":"Wolf","year":"2024","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130415_bb0065","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa2403991","article-title":"Phase 3 trial of Cabozantinib to treat advanced neuroendocrine tumors","volume":"392","author":"Chan","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2025.130415_bb0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/bs.podrm.2022.11.002","article-title":"Crizotinib: A comprehensive profile","volume":"48","author":"Abdelgalil","year":"2023","journal-title":"Profiles Drug Subst Excip Relat Methodol"},{"key":"10.1016\/j.bmcl.2025.130415_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116477","article-title":"Recent advances in c-met-based dual inhibitors in the treatment of cancers","volume":"272","author":"Jin","year":"2024","journal-title":"Eur J Med Chem"},{"issue":"21","key":"10.1016\/j.bmcl.2025.130415_bb0080","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1080\/07391102.2022.2162128","article-title":"Dynamic conformational states of apo, ATP and cabozantinib bound TAM kinases to differentiate active-inactive kinetic models","volume":"41","author":"Naresh","year":"2023","journal-title":"J Biomol Struct Dyn"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130415_bb0085","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.3390\/biomedicines11092406","article-title":"Involvement of the AKT pathway in resistance to Erlotinib and Cabozantinib in triple-negative breast Cancer cell lines","volume":"11","author":"Lefebvre","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130415_bb0090","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3390\/molecules29020475","article-title":"Design, synthesis, and biological evaluation of 2-substituted aniline pyrimidine derivatives as potent dual Mer\/c-met inhibitors","volume":"29","author":"Huang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130415_bb0095","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/biom15081180","article-title":"Discovery of novel 2-substituted aniline pyrimidine based derivatives as potent Mer\/c-met dual inhibitors with improvement bioavailability","volume":"15","author":"Yang","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.bmcl.2025.130415_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113648","article-title":"Structure-guided design and development of novel N-phenylpyrimidin-2-amine derivatives as potential c-met inhibitors","volume":"223","author":"Huang","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130415_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12935-024-03235-2","article-title":"The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-met and FGF19\/FGFR4 expression","volume":"24","author":"Lee","year":"2024","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.bmcl.2025.130415_bb0110","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1021\/acs.jmedchem.8b01229","article-title":"Highly selective MERTK inhibitors achieved by a single methyl group","volume":"61","author":"Zhao","year":"2018","journal-title":"J Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:15:03Z","timestamp":1761639303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25003245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"alternative-id":["S0960894X25003245"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130415","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of novel potent dual Mer\/c-Met inhibitors based on structural optimization","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"130415"}}