{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:08:05Z","timestamp":1778792885887,"version":"3.51.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202103108"],"award-info":[{"award-number":["tsqn202103108"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tstp20240852"],"award-info":[{"award-number":["tstp20240852"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2023YFC2606500"],"award-info":[{"award-number":["2023YFC2606500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmcl.2025.130427","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:54:12Z","timestamp":1759629252000},"page":"130427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Privileged scaffold repurposed: the evolving role of quinolone derivatives in antiviral therapy"],"prefix":"10.1016","volume":"130","author":[{"given":"Hui","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130427_bb0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12916-025-04022-0","article-title":"Cilnidipine exerts antiviral effects in vitro and in vivo by inhibiting the internalization and fusion of influenza A virus","volume":"23","author":"Li","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.bmcl.2025.130427_bb0010","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1093\/cid\/ciad344","article-title":"Direct-acting antiviral therapy for treatment of acute and recent hepatitis C virus infection: a narrative review","volume":"77","author":"Martinello","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130427_bb0015","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03331-22","article-title":"Combinations of host- and virus-targeting antiviral drugs confer synergistic suppression of SARS-CoV-2","volume":"10","author":"Wagoner","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130427_bb0020","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/QCO.0000000000001113","article-title":"Lenacapavir: a first-in-class capsid inhibitor for HIV treatment and prevention","volume":"38","author":"Mckellar","year":"2025","journal-title":"Curr Opin Infect Dis"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130427_bb0025","article-title":"Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered spike-binding peptides","volume":"97","author":"Llewellyn George","year":"2023","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1517\/14656566.2012.642865","article-title":"Combination nucleoside\/nucleotide reverse transcriptase inhibitors for treatment of HIV infection","volume":"13","author":"Akanbi","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.bmcl.2025.130427_bb0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40199-017-0177-x","article-title":"Combination of sofosbuvir, pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection: a systematic review and meta-analysis","volume":"25","author":"Dolatimehr","year":"2017","journal-title":"DARU J Pharm Sci"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130427_bb0040","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00110-24","article-title":"Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1","volume":"68","author":"Schalkwijk","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"10.1016\/j.bmcl.2025.130427_bb0045","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/hiv.13520","article-title":"Treatment-emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: a case series","volume":"24","author":"DeKoven","year":"2023","journal-title":"HIV Med"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130427_bb0050","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2174\/1568026620666200129100219","article-title":"4-Oxoquinoline derivatives as antivirals: a ten years overview","volume":"20","author":"Batalha","year":"2020","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmcl.2025.130427_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108240","article-title":"Exploring 4-quinolone-3-carboxamide derivatives: a versatile framework for emerging biological applications","volume":"157","author":"Andrade","year":"2025","journal-title":"Bioorg Chem"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130427_bb0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1021\/acsinfecdis.4c00041","article-title":"Target-mediated fluoroquinolone resistance in Neisseria gonorrhoeae: actions of ciprofloxacin against gyrase and topoisomerase IV","volume":"10","author":"Collins","year":"2024","journal-title":"ACS Infect Dis"},{"issue":"26","key":"10.1016\/j.bmcl.2025.130427_bb0065","doi-asserted-by":"crossref","first-page":"24093","DOI":"10.1021\/acsomega.3c03406","article-title":"Atomic-scale resolution insights into structural and dynamic differences between ofloxacin and levofloxacin","volume":"8","author":"Pradhan","year":"2023","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130427_bb0070","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/095632029800900504","article-title":"Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12","volume":"9","author":"Witvrouw","year":"1998","journal-title":"Antivir Chem Chemother"},{"issue":"15","key":"10.1016\/j.bmcl.2025.130427_bb0075","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1016\/j.bmcl.2012.06.020","article-title":"Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1","volume":"22","author":"Faro","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130427_bb0080","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s13555-024-01101-7","article-title":"Herpes zoster recurrence: a narrative review of the literature","volume":"14","author":"Parikh","year":"2024","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.bmcl.2025.130427_bb0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.enz.2021.07.003","article-title":"DNA polymerases of herpesviruses and their inhibitors","volume":"50","author":"Piret","year":"2021","journal-title":"The Enzymes"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0090","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.1038\/s41467-021-23312-8","article-title":"Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase","volume":"12","author":"Hayes","year":"2021","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130427_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28985","article-title":"Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: low prevalence and novel mutations","volume":"95","author":"Kuo","year":"2023","journal-title":"J Med Virol"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0166-3542(01)00208-X","article-title":"Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses","volume":"54","author":"Brideau","year":"2002","journal-title":"Antivir Res"},{"issue":"20","key":"10.1016\/j.bmcl.2025.130427_bb0105","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1016\/j.cell.2024.07.048","article-title":"Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance","volume":"187","author":"Shankar","year":"2024","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130427_bb0110","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bmcl.2005.10.111","article-title":"Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogues","volume":"16","author":"Lucero","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130427_bb0115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/1568026623666221220121806","article-title":"Chloroquinolone carboxamide derivatives as new anti-HSV-1 promising drugs","volume":"23","author":"Souza","year":"2023","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmcl.2025.130427_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117490","article-title":"Rapid discovery of pseudorabies virus inhibitors repurposed from the antimicrobial agent ciprofloxacin","volume":"289","author":"Wei","year":"2025","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3851\/IMP3329","article-title":"Antiviral activity of 4-oxoquinoline-3-carboxamide derivatives against bovine herpesvirus type 5","volume":"25","author":"Pinto","year":"2020","journal-title":"Antivir Ther"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.21037\/hbsn-2024-754","article-title":"2024 latest report on hepatitis B virus epidemiology in China: current status, changing trajectory, and challenges","volume":"14","author":"Yan","year":"2025","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.bmcl.2025.130427_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.787770","article-title":"Dynamics of serum pregenome RNA in chronic hepatitis B patients receiving 96-month nucleos(t)ide analog therapy","volume":"9","author":"Tao","year":"2022","journal-title":"Front Med"},{"issue":"13","key":"10.1016\/j.bmcl.2025.130427_bb0140","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1016\/j.bmc.2008.05.029","article-title":"Synthesis and anti-hepatitis B virus evaluation of novel ethyl 6-hydroxyquinoline-3-carboxylates in vitro","volume":"16","author":"Liu","year":"2008","journal-title":"Bioorg Med Chem"},{"issue":"23","key":"10.1016\/j.bmcl.2025.130427_bb0145","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1021\/acs.jmedchem.8b01245","article-title":"Discovery of RG7834: the first-in-class selective and orally available small molecule hepatitis B virus expression inhibitor with novel mechanism of action","volume":"61","author":"Han","year":"2018","journal-title":"J Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130427_bb0150","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jhep.2017.10.014","article-title":"A novel orally available small molecule that inhibits hepatitis B virus expression","volume":"68","author":"Mueller","year":"2018","journal-title":"J Hepatol"},{"issue":"13","key":"10.1016\/j.bmcl.2025.130427_bb0155","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1021\/jm500340h","article-title":"Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression","volume":"57","author":"Donalisio","year":"2014","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0160","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/imr.12063","article-title":"HIV and co-infections","volume":"254","author":"Chang","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bmcl.2025.130427_bb0165","first-page":"14","article-title":"Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications","author":"Mataramvura","year":"2023","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130427_bb0170","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1371\/journal.pmed.0050158","article-title":"Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy","volume":"5","author":"Johnson","year":"2008","journal-title":"PLoS Med"},{"issue":"22","key":"10.1016\/j.bmcl.2025.130427_bb0175","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1021\/jm049721p","article-title":"Structure modifications of 6-aminoquinolones with potent anti-HIV activity","volume":"47","author":"Tabarrini","year":"2004","journal-title":"J Med Chem"},{"issue":"17","key":"10.1016\/j.bmcl.2025.130427_bb0180","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1021\/jm701585h","article-title":"Structure-activity relationship study on anti-HIV 6-desfluoroquinolones","volume":"51","author":"Tabarrini","year":"2008","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bmc.2010.11.045","article-title":"Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid","volume":"19","author":"Curreli","year":"2011","journal-title":"Bioorg Med Chem"},{"issue":"16","key":"10.1016\/j.bmcl.2025.130427_bb0190","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1021\/jm8003784","article-title":"Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors","volume":"51","author":"Pasquini","year":"2008","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/j.bmcl.2025.130427_bb0195","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1021\/jm401902n","article-title":"Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants","volume":"57","author":"Zhao","year":"2014","journal-title":"J Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2025.130427_bb0200","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf027","article-title":"Influenza A virus NS2 protein acts on vRNA-resident polymerase to drive the transcription to replication switch","volume":"53","author":"Zhang","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0205","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2528536","article-title":"Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study","volume":"14","author":"Wang","year":"2025","journal-title":"Emerg Microbes Infect"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130427_bb0210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrmicro.2016.87","article-title":"Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis","volume":"14","author":"Te Velthuis","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130427_bb0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-12-405880-4.00006-8","article-title":"Influenza virus resistance to antiviral therapy","volume":"67","author":"van der Vries","year":"2013","journal-title":"Adv Pharmacol"},{"issue":"24","key":"10.1016\/j.bmcl.2025.130427_bb0220","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1016\/j.bmc.2015.11.028","article-title":"1,2,3-Triazolyl-4-oxoquinolines: a feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza a and B viruses","volume":"23","author":"Boechat","year":"2015","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0225","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1021\/acs.jmedchem.1c01527","article-title":"Lead optimization of influenza virus RNA polymerase inhibitors targeting PA-PB1 interaction","volume":"65","author":"Mizuta","year":"2022","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2025.130427_bb0230","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.1038\/s41598-017-10021-w","article-title":"Structure-based drug discovery for combating influenza virus by targeting the PA-PB1 interaction","volume":"7","author":"Watanabe","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2025.130427_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.130081","article-title":"Synthesis and biological evaluation of substituted quinolines containing piperazine moieties against influenza A virus","volume":"118","author":"Li","year":"2025","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130427_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28499","article-title":"Inhibition of influenza a virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein","volume":"95","author":"Zhang","year":"2023","journal-title":"J Med Virol"},{"key":"10.1016\/j.bmcl.2025.130427_bb0245","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejmech.2014.03.074","article-title":"Synthesis, antiproliferative and anti-dengue virus evaluations of 2-aroyl-3-arylquinoline derivatives","volume":"79","author":"Tseng","year":"2014","journal-title":"Eur J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130427_bb0250","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3851\/IMP3231","article-title":"A quinoline compound inhibits the replication of dengue virus serotypes 1-4 in Vero cells","volume":"23","author":"Beesetti","year":"2018","journal-title":"Antivir Ther"},{"key":"10.1016\/j.bmcl.2025.130427_bb0255","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ejmech.2017.01.007","article-title":"N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity","volume":"127","author":"Barbosa-Lima","year":"2017","journal-title":"Eur J Med Chem"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130427_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126881","article-title":"Quinolone-N-acylhydrazone hybrids as potent Zika and chikungunya virus inhibitors","volume":"30","author":"Marra","year":"2020","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130427_bb0265","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1021\/jm051250z","article-title":"Synthesis and anti-BVDV activity of acridones as new potential antiviral agents","volume":"49","author":"Tabarrini","year":"2006","journal-title":"J Med Chem"},{"issue":"10","key":"10.1016\/j.bmcl.2025.130427_bb0270","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/jm801608u","article-title":"Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor","volume":"52","author":"Manfroni","year":"2009","journal-title":"J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2025.130427_bb0275","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1021\/jm401362f","article-title":"The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors","volume":"57","author":"Manfroni","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130427_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2025.106145","article-title":"Hepato-selective dihydroquinolizinones active against hepatitis A virus in vitro and in vivo","volume":"237","author":"Misumi","year":"2025","journal-title":"Antivir Res"},{"issue":"9","key":"10.1016\/j.bmcl.2025.130427_bb0285","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1021\/acs.jmedchem.6b01227","article-title":"Inhibitors of influenza virus polymerase acidic (PA) endonuclease: contemporary developments and perspectives","volume":"60","author":"Ju","year":"2017","journal-title":"J Med Chem"},{"issue":"12","key":"10.1016\/j.bmcl.2025.130427_bb0290","first-page":"2158","article-title":"Heterocycle-thioacetic acid motif: a privileged molecular scaffold with potent, broad-ranging pharmacological activities","volume":"19","author":"Yu\u2019ning","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"8","key":"10.1016\/j.bmcl.2025.130427_bb0295","first-page":"1380","article-title":"Privileged scaffolds or promiscuous binders: a glance of pyrrolo[2,1-f][1,2,4]triazines and related bridgehead nitrogen heterocycles in medicinal chemistry","volume":"19","author":"Liu","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"21","key":"10.1016\/j.bmcl.2025.130427_bb0300","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1016\/j.bmcl.2016.09.071","article-title":"First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via \u201cprivileged scaffold\u201d refining approach","volume":"26","author":"Kang","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"issue":"10476","key":"10.1016\/j.bmcl.2025.130427_bb0305","first-page":"e1","article-title":"Chikungunya virus disease returns to Europe: a turning point for the global arboviral landscape","volume":"405","author":"Zumla","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2025.130427_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2025.100084","article-title":"Phenol and chromone compounds for in silico inhibition of nsP2 and nsP3 of Chikungunya virus","volume":"3","author":"Oliveira Lima","year":"2025","journal-title":"Pharm Sci Adv"},{"issue":"26","key":"10.1016\/j.bmcl.2025.130427_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202307215","article-title":"High-throughput miniaturized synthesis of PROTAC-like molecules","volume":"20","author":"Tian","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.bmcl.2025.130427_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2025.100080","article-title":"Artificial intelligence in human immunodeficiency virus mutation prediction and drug design: advancing personalized treatment and prevention","volume":"3","author":"Oyediran","year":"2025","journal-title":"Pharm Sci Adv"},{"issue":"2","key":"10.1016\/j.bmcl.2025.130427_bb0325","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41589-023-01458-4","article-title":"DNA-encoded library-enabled discovery of proximity-inducing small molecules","volume":"20","author":"Mason","year":"2024","journal-title":"Nat Chem Biol"},{"issue":"26","key":"10.1016\/j.bmcl.2025.130427_bb0330","article-title":"Accelerating PROTACs discovery through a direct-to-biology platform enabled by modular photoclick chemistry","volume":"11","author":"Yan","year":"2024","journal-title":"Adv Sci (Weinh)"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:14:10Z","timestamp":1778789650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25003361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":66,"alternative-id":["S0960894X25003361"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130427","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Privileged scaffold repurposed: the evolving role of quinolone derivatives in antiviral therapy","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130427"}}