{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:21:35Z","timestamp":1761639695124,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Liaoning Province Educational Department","doi-asserted-by":"publisher","award":["LJ222410163050"],"award-info":[{"award-number":["LJ222410163050"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101904"],"award-info":[{"award-number":["82101904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-YQ-17","2023-MS-195"],"award-info":[{"award-number":["2022-YQ-17","2023-MS-195"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmcl.2025.130430","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:53:14Z","timestamp":1759798394000},"page":"130430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors"],"prefix":"10.1016","volume":"130","author":[{"given":"Yongzhi","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minni","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130430_bb0005","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide","volume":"156","author":"Filho","year":"2025","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bmcl.2025.130430_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106535","article-title":"Breast cancer: biology, biomarkers, and treatments","volume":"84","author":"Barzaman","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.bmcl.2025.130430_bb0020","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMra1100831","article-title":"Sirtuins, aging, and medicine","volume":"364","author":"Guarente","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2025.130430_bb0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.bmcl.2025.130430_bb0030","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.M609554200","article-title":"Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1","volume":"282","author":"Tanno","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0035","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"MBoC"},{"key":"10.1016\/j.bmcl.2025.130430_bb0040","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1101\/gad.1412706","article-title":"SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis","volume":"20","author":"Vaquero","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.bmcl.2025.130430_bb0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200205057","article-title":"The human silent information regulator (sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide\u2013dependent deacetylase","volume":"158","author":"Schwer","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0050","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2006.06.057","article-title":"SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic \u03b2 cells","volume":"126","author":"Haigis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2025.130430_bb0055","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2009.02.026","article-title":"SIRT5 deacetylates carbamoyl phosphate Synthetase 1 and regulates the urea cycle","volume":"137","author":"Nakagawa","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2025.130430_bb0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2005.11.044","article-title":"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6","volume":"124","author":"Mostoslavsky","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2025.130430_bb0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature11043","article-title":"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation","volume":"487","author":"Barber","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2025.130430_bb0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.bmcl.2025.130430_bb0075","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.3390\/ijms24119655","article-title":"The role of increased expression of Sirtuin 6 in the prevention of premature aging Pathomechanisms","volume":"24","author":"Dzidek","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.bmcl.2025.130430_bb0080","article-title":"SIRT6 widely regulates aging, immunity, and Cancer","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0085","doi-asserted-by":"crossref","first-page":"14575","DOI":"10.1074\/jbc.M111.218990","article-title":"Structure and biochemical functions of SIRT6","volume":"286","author":"Pan","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0090","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.molcel.2012.09.030","article-title":"The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis","volume":"48","author":"Dominy","year":"2012","journal-title":"Mol Cell"},{"issue":"7","key":"10.1016\/j.bmcl.2025.130430_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039847","article-title":"Over expression of wild type or a catalytically dead mutant of SIRTUIN 6 does not influence NF\u03baB responses. Ko BCB, ed.","volume":"7","author":"Grimley","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmcl.2025.130430_bb0100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ncomms1443","article-title":"SIRT6 is required for maintenance of telomere position effect in human cells","volume":"2","author":"Tennen","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2025.130430_bb0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40170-021-00240-1","article-title":"SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice","volume":"9","author":"Becherini","year":"2021","journal-title":"Cancer Metab"},{"key":"10.1016\/j.bmcl.2025.130430_bb0110","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1074\/jbc.M112.405928","article-title":"The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells","volume":"288","author":"Sharma","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55828","article-title":"Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice","volume":"9","author":"Meng","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.bmcl.2025.130430_bb0120","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.celrep.2017.02.082","article-title":"Sirt6 promotes DNA end joining in iPSCs derived from old mice","volume":"18","author":"Chen","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmcl.2025.130430_bb0125","article-title":"The emerging double-edged sword role of Sirtuins in the gastric inflammation-carcinoma sequence revealed by bulk and single-cell transcriptomes","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0130","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1016\/j.ygeno.2020.04.027","article-title":"Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines","volume":"112","author":"Krishnamoorthy","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.bmcl.2025.130430_bb0135","article-title":"Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity","volume":"8","author":"Hu","year":"2018","journal-title":"Oncol Rep"},{"key":"10.1016\/j.bmcl.2025.130430_bb0140","article-title":"SIRT6 protects cardiomyocytes against ischemia\/reperfusion injury by augmenting FoxO3\u03b1-dependent antioxidant defense mechanisms","volume":"111(2):13","author":"Wang","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0145","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.2147\/CMAR.S157661","article-title":"Downregulation of FOXO6 in breast cancer promotes epithelial&ndash;mesenchymal transition and facilitates migration and proliferation of cancer cells","volume":"10","author":"Ye","year":"2018","journal-title":"CMAR"},{"key":"10.1016\/j.bmcl.2025.130430_bb0150","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/carcin\/bgt098","article-title":"SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer","volume":"34","author":"Khongkow","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmcl.2025.130430_bb0155","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1096\/fj.201800321R","article-title":"SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells","volume":"33","author":"Sociali","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.bmcl.2025.130430_bb0160","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1038\/s41598-022-16405-x","article-title":"Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells","volume":"12","author":"Hong","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2025.130430_bb0165","first-page":"1","article-title":"SIRT6 promotes the progression of prostate Cancer via regulating the Wnt\/\u03b2-catenin signaling pathway. Wang F, ed","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0170","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fonc.2018.00538","article-title":"SIRT6 is involved in the progression of ovarian carcinomas via \u03b2-catenin-mediated epithelial to mesenchymal transition","volume":"8","author":"Bae","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.bmcl.2025.130430_bb0175","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.7150\/thno.100667","article-title":"Targeting sirtuins for cancer therapy: epigenetics modifications and beyond","volume":"14","author":"Shen","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bmcl.2025.130430_bb0180","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ejmech.2015.08.024","article-title":"Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics","volume":"102","author":"Sociali","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0185","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/15384047.2019.1702397","article-title":"SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia","volume":"21","author":"Kong","year":"2020","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.bmcl.2025.130430_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-020-01759-9","article-title":"Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma","volume":"39","author":"Zhang","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bmcl.2025.130430_bb0195","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1021\/jm500487d","article-title":"Discovery of novel and selective SIRT6 inhibitors","volume":"57","author":"Parenti","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.abb.2017.12.009","article-title":"Trichostatin a inhibits deacetylation of histone H3 and p53 by SIRT6","volume":"638","author":"Wood","year":"2018","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bmcl.2025.130430_bb0205","doi-asserted-by":"crossref","first-page":"10922","DOI":"10.1021\/acs.jmedchem.8b01455","article-title":"Structural basis of Sirtuin 6 inhibition by the Hydroxamate Trichostatin a: implications for protein Deacylase drug development","volume":"61","author":"You","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41419-023-06018-1","article-title":"Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine","volume":"14","author":"Song","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bmcl.2025.130430_bb0215","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.apsb.2021.06.015","article-title":"Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells","volume":"12","author":"Zhang","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmcl.2025.130430_bb0220","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.apsb.2023.11.014","article-title":"Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo","volume":"14","author":"Xu","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmcl.2025.130430_bb0225","doi-asserted-by":"crossref","first-page":"21975","DOI":"10.1021\/acs.jmedchem.4c01921","article-title":"Structure-guided discovery of subtype selective SIRT6 inhibitors with a \u03b2-carboline skeleton for the treatment of breast cancer","volume":"67","author":"Liang","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cbic.201500482","article-title":"46-1N-Acylethanolamines bind to SIRT6","volume":"17","author":"Rahnasto-Rilla","year":"2016","journal-title":"Chembiochem"},{"key":"10.1016\/j.bmcl.2025.130430_bb0235","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3390\/molecules24030528","article-title":"47Catechin in human health and disease","volume":"24","author":"Isemura","year":"2019","journal-title":"Molecules"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:16:43Z","timestamp":1761639403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"alternative-id":["S0960894X25003397"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130430","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130430"}}