{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:12:13Z","timestamp":1780917133415,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3506700"],"award-info":[{"award-number":["2024YFC3506700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022977","name":"Frontiers Science Center for Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bmcl.2025.130477","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T22:12:43Z","timestamp":1763590363000},"page":"130477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis of dehydroabietic acid derivatives as mast cell stabilizers"],"prefix":"10.1016","volume":"131","author":[{"given":"Tao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahareh","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Guo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130477_bb0005","article-title":"Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0010","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.3390\/ijms23042249","article-title":"The multifaceted roles of mast cells in immune homeostasis, infections and cancers","volume":"23","author":"Sobiepanek","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2025.130477_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1418897","article-title":"Mast cell stabilizers: from pathogenic roles to targeting therapies","volume":"15","author":"Cao","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2147\/ITT.S261416","article-title":"Anti-IgE for the treatment of chronic urticaria","volume":"10","author":"Wedi","year":"2021","journal-title":"Immunotargets Ther"},{"key":"10.1016\/j.bmcl.2025.130477_bb0025","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/ACI.0b013e3283303ebb","article-title":"Multiple action agents and the eye: do they really stabilize mast cells?","volume":"9","author":"Lambiase","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0030","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3389\/fimmu.2018.01873","article-title":"The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets","volume":"9","author":"Thangam","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0035","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4049\/jimmunol.1501932","article-title":"Fluvastatin suppresses mast cell and basophil IgE responses: genotype-dependent effects","volume":"196","author":"Kolawole","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0040","doi-asserted-by":"crossref","first-page":"29714","DOI":"10.1021\/acsomega.0c03320","article-title":"Design of potential pharmaceutical-based metal complexes derived from cromolyn a mast cell stabilizer","volume":"5","author":"Rodriguez","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmcl.2025.130477_bb0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000236505","article-title":"Effect of lodoxamide on in vitro and in vivo conjunctival immediate hypersensitivity responses in rats","volume":"101","author":"Yanni","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000438605","article-title":"Anti-allergic drugs tranilast and ketotifen dose-dependently exert mast cell-stabilizing properties","volume":"38","author":"Baba","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bmcl.2025.130477_bb0055","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/s-2006-959744","article-title":"Abietane acids: sources, biological activities, and therapeutic uses","volume":"59","author":"San Feliciano","year":"1993","journal-title":"Planta Med"},{"key":"10.1016\/j.bmcl.2025.130477_bb0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13273-021-00118-9","article-title":"Dehydroabietic acid inhibits the gastric cancer cell growth via induced apoptosis and cell cycle arrest","volume":"17","author":"Kim","year":"2021","journal-title":"Mol Cell Toxicol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117021","article-title":"Diterpenes of Pinus pinaster aiton with anti-inflammatory, analgesic, and antibacterial activities","volume":"318","author":"Michavila Puente-Villegas","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0070","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s12272-011-0608-z","article-title":"Inhibition of nitric oxide production in RAW 264.7 macrophages by diterpenoids from Phellinus pini","volume":"34","author":"Jang","year":"2011","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmcl.2025.130477_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102867","article-title":"Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation","volume":"299","author":"Crozier","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2025.130477_bb0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fitote.2015.08.005","article-title":"19(4-->3)-abeo-abietane diterpenoids from Scrophularia dentata Royle ex Benth","volume":"106","author":"Zhang","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmcl.2025.130477_bb0085","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3389\/fimmu.2019.01103","article-title":"Scrodentoid a inhibits mast cell-mediated allergic response by blocking the Lyn- Fc\u03b5RI\u03b2 interaction","volume":"10","author":"Qian","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.bmcl.2025.130477_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.tet.2021.132031","article-title":"An asymmetric synthesis of (+)-Scrodentoid a from dehydroabietic acid","volume":"85","author":"Song","year":"2021","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2025.130477_bb0095","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/toxins14090632","article-title":"Recent advances on biological activities and structural modifications of dehydroabietic acid","volume":"14","author":"Hao","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.bmcl.2025.130477_bb0100","article-title":"Design, synthesis, and anti-glioma activity evaluation of dehydroabietic acid derivatives","volume":"10","author":"Liu","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmcl.2025.130477_bb0105","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1016\/j.bmcl.2008.08.078","article-title":"Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C","volume":"18","author":"Cui","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130477_bb0110","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1016\/j.bmc.2010.09.072","article-title":"Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives","volume":"18","author":"Cui","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2025.130477_bb0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bmcl.2015.12.038","article-title":"The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid","volume":"26","author":"Cui","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130477_bb0120","doi-asserted-by":"crossref","first-page":"29788","DOI":"10.1039\/C9RA04828F","article-title":"Biorenewable rosin derived benzocyclobutene resin: a thermosetting material with good hydrophobicity and low dielectric constant","volume":"9","author":"Fu","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmcl.2025.130477_bb0125","doi-asserted-by":"crossref","first-page":"11666","DOI":"10.1039\/D2SC03479D","article-title":"Total syntheses of naturally occurring antiviral indolosesquiterpene alkaloids, xiamycins C-F via Csp3-H functionalization","volume":"13","author":"Munda","year":"2022","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmcl.2025.130477_bb0130","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1039\/c39790000866","article-title":"Stereoselective synthesis of arylated (E)-alkenes by the reaction of alk-1-enylboranes with aryl halides in the presence of palladium catalyst","author":"Miyaura","year":"1979","journal-title":"J Chem Soc Chem Commun"},{"key":"10.1016\/j.bmcl.2025.130477_bb0135","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1246\/cl.1983.927","article-title":"Palladium-catalyzed aromatic amination of aryl bromides with N N-Di-ethylamino-tributyltin","volume":"12","author":"Kosugi","year":"1983","journal-title":"Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130477_bb0140","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/acs.jnatprod.2c00464","article-title":"Antiviral profiling of C-18- or C-19-functionalized semisynthetic abietane diterpenoids","volume":"85","author":"Gonzalez-Cardenete","year":"2022","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2025.130477_bb0145","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1246\/bcsj.61.2405","article-title":"The synthesis of methyl (15S)-16-hydroxydehydroabietate and its (15R)-epimer","volume":"61","author":"Matsumoto","year":"1988","journal-title":"Bull Chem Soc Jpn"},{"key":"10.1016\/j.bmcl.2025.130477_bb0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/all.13657","article-title":"Mast cell disorders: from infancy to maturity","volume":"74","author":"Wilcock","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.bmcl.2025.130477_bb0155","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.3390\/molecules28124743","article-title":"Tricyclic diterpenoids selectively suppress androgen receptor-positive prostate cancer cells","volume":"28","author":"Sekhon","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130477_bb0160","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3390\/cells10082170","article-title":"Roles of IgE and histamine in mast cell maturation","volume":"10","author":"Tanaka","year":"2021","journal-title":"Cells"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25003865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:33:46Z","timestamp":1780914826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25003865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":32,"alternative-id":["S0960894X25003865"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130477","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of dehydroabietic acid derivatives as mast cell stabilizers","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130477"}}