{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:37:12Z","timestamp":1782387432492,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["CARS-21"],"award-info":[{"award-number":["CARS-21"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC0624"],"award-info":[{"award-number":["2022NSFSC0624"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYZDXK-2023244"],"award-info":[{"award-number":["ZYYZDXK-2023244"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E002"],"award-info":[{"award-number":["CI2023E002"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bmcl.2025.130514","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:20:11Z","timestamp":1766506811000},"page":"130514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis, and biological evaluation of novel 4-aminoquinoline derivatives as potent membrane-targeting antifungal agents"],"prefix":"10.1016","volume":"133","author":[{"given":"Jing","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2025.130514_bb0005","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.cmi.2024.03.006","article-title":"New treatment options for critically important WHO fungal priority pathogens","volume":"31","author":"Kriegl","year":"2025","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.bmcl.2025.130514_bb0010","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmcl.2025.130514_bb0015","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41579-023-00960-9","article-title":"The rapid emergence of antifungal-resistant human-pathogenic fungi","volume":"21","author":"Lockhart","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2025.130514_bb0020","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1039\/D3MD00151B","article-title":"Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance","volume":"14","author":"Mehta","year":"2023","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s40588-024-00219-8","article-title":"Emerging antifungal resistance in fungal pathogens","volume":"11","author":"Hui","year":"2024","journal-title":"Curr Clin Microbiol"},{"key":"10.1016\/j.bmcl.2025.130514_bb0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/14787210.2023.2203383","article-title":"The antifungal pipeline for invasive fungal diseases: what does the future hold?","volume":"21","author":"Neoh","year":"2023","journal-title":"Expert Rev Anti-Infect Ther"},{"key":"10.1016\/j.bmcl.2025.130514_bb0035","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1093\/jpids\/piad115","article-title":"Pipeline of novel antifungals for invasive fungal disease in transplant recipients: a pediatric perspective","volume":"13","author":"Hsu","year":"2024","journal-title":"J Pediatr Infect Dis Soc"},{"key":"10.1016\/j.bmcl.2025.130514_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107954","article-title":"Discovery of new 4-aminoquinoline derivatives containing an amine or hydroxamic acid terminal as multifunctional agents for the treatment of Alzheimer\u2019s disease","volume":"153","author":"Zhai","year":"2024","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115458","article-title":"Recent developments in antimalarial activities of 4-aminoquinoline derivatives","volume":"256","author":"Ravindar","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138677","article-title":"4-Aminoquinoline derivatives as potent inhibitors of pancreatic cancer: synthesis, evaluation and docking studies","volume":"1312","author":"Chirra","year":"2024","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmcl.2025.130514_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117127","article-title":"Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff\u2019s bases as promising antimicrobial agents","volume":"283","author":"Shakir","year":"2025","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0060","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3390\/molecules21080969","article-title":"Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-pyrazoline with antiproliferative and antifungal activity","volume":"21","author":"Montoya","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2025.130514_bb0065","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jhet.3791","article-title":"Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives","volume":"57","author":"Bhat","year":"2020","journal-title":"J Heterocycl Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202401828","article-title":"New quinoline derivatives and their antimicrobial potential against Candida albicans and Staphylococcus aureus","volume":"9","author":"Glanzmann","year":"2024","journal-title":"Chemistryselect"},{"key":"10.1016\/j.bmcl.2025.130514_bb0075","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41522-024-00608-3","article-title":"Long-chain 4-aminoquinolines inhibit filamentation and increase efficacy of nystatin against Candida albicans infections in vivo","volume":"10","author":"Pavic","year":"2024","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.bmcl.2025.130514_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128877","article-title":"Synthesis and biological evaluation of new 2-substituted 4-amino-quinolines and -quinazoline as potential antifungal agents","volume":"72","author":"Qin","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130514_bb0085","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ejmech.2014.06.066","article-title":"The synthesis and biological evaluation of new DNA-directed alkylating agents, phenyl N-mustard-4-anilinoquinoline conjugates containing a urea linker","volume":"83","author":"Marvania","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114195","article-title":"Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy","volume":"233","author":"Yin","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115842","article-title":"Natural phytoalexins inspired the discovery of new biphenyls as potent antifungal agents for treatment of invasive fungal infections","volume":"261","author":"Liu","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106679","article-title":"Novel antimicrobial peptide DvAMP serves as a promising antifungal agent against Cryptococcus neoformans","volume":"138","author":"Yang","year":"2023","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129211","article-title":"Hydroxy-xanthones as promising antiviral agents: synthesis and biological evaluation against human coronavirus OC43","volume":"84","author":"Dean","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2025.130514_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2025.130514_bb0115","doi-asserted-by":"crossref","first-page":"W469","DOI":"10.1093\/nar\/gkae254","article-title":"Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction","volume":"52","author":"Myung","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmcl.2025.130514_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108788","article-title":"N-substituted phthalimide-carboxylic acid hybrids as dual-targeted aldose reductase inhibitors: synthesis, mechanistic insights, and cancer-relevant profiling","volume":"163","author":"Zognjani","year":"2025","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118416","article-title":"Phthalimide-benzoic acid hybrids as potent aldose reductase inhibitors: synthesis, enzymatic kinetics, and in silico characterization","volume":"131","author":"Hoti","year":"2025","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108689","article-title":"Fluorenyl-phthalimide hybrids as potent aldose reductase inhibitors with selective anticancer activity: rational design, synthesis, and molecular insights","volume":"163","author":"Gundogdu","year":"2025","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2025.130514_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108861","article-title":"Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: rational design, synthesis, and multi-level characterization","volume":"164","author":"G\u00fcle\u00e7","year":"2025","journal-title":"Bioorg Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25004238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X25004238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:21:48Z","timestamp":1781943708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X25004238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":27,"alternative-id":["S0960894X25004238"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130514","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of novel 4-aminoquinoline derivatives as potent membrane-targeting antifungal agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2025.130514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130514"}}