{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:41:55Z","timestamp":1787319715067,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177137"],"award-info":[{"award-number":["22177137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bmcl.2026.130537","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:19:12Z","timestamp":1767889152000},"page":"130537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Spinosyn A derivatives as ASS1 activators and tumor inhibitors"],"prefix":"10.1016","volume":"134","author":[{"given":"Xin-Yu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-You","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-You","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bmcl.2026.130537_bb0005","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.cell.2018.07.019","article-title":"Urea cycle dysregulation generates clinically relevant genomic and biochemical signatures","volume":"174","author":"Lee","year":"2018","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130537_bb0010","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41568-018-0054-z","article-title":"Rewiring urea cycle metabolism in cancer to support anabolism","volume":"18","author":"Keshet","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130537_bb0015","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1158\/0008-5472.CAN-13-1702","article-title":"Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging","volume":"74","author":"Allen","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2026.130537_bb0020","first-page":"127","article-title":"Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells","author":"Xia","year":"2025","journal-title":"Cell Signal"},{"key":"10.1016\/j.bmcl.2026.130537_bb0025","first-page":"13","article-title":"A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors","author":"Ding","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.bmcl.2026.130537_bb0030","article-title":"Argininosuccinate synthase 1, arginine deprivation therapy and cancer management","volume":"13","author":"Sun","year":"2022","journal-title":"Front Pharmacol"},{"issue":"7578","key":"10.1016\/j.bmcl.2026.130537_bb0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nature15529","article-title":"Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis","volume":"527","author":"Rabinovich","year":"2015","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.bmcl.2026.130537_bb0040","doi-asserted-by":"crossref","first-page":"E3423","DOI":"10.1073\/pnas.1606022113","article-title":"Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism","volume":"113","author":"Madiraju","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"10.1016\/j.bmcl.2026.130537_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310668","article-title":"Unlocking the potential of arginine deprivation therapy: recent breakthroughs and promising future for cancer treatment","volume":"24","author":"Chu","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130537_bb0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40170-021-00264-7","article-title":"The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer","volume":"9","author":"Giatromanolaki","year":"2021","journal-title":"Cancer Metab"},{"issue":"32","key":"10.1016\/j.bmcl.2026.130537_bb0055","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.2174\/0929867331666230911162527","article-title":"Alkaloids as additional weapons in the fight against breast cancer: a review","volume":"31","author":"Chahat","year":"2024","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmcl.2026.130537_bb0060","article-title":"Exploring the potential of terpenoids as a possible treatment for cancer: structure-activity relationship and mechanistic studies","author":"Singh","year":"2024","journal-title":"Curr Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130537_bb0065","first-page":"737","article-title":"A review on plant flavonoids as potential anticancer agents","volume":"25","author":"Kapoor","year":"2021","journal-title":"Curr Org Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130537_bb0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10937404.2019.1689878","article-title":"Properties, toxicity and current applications of the biolarvicide spinosad","volume":"23","author":"Santos","year":"2020","journal-title":"J Toxicol Environ Heal B"},{"key":"10.1016\/j.bmcl.2026.130537_bb0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.actatropica.2013.11.006","article-title":"Genetics, cross-resistance and mechanism of resistance to spinosad in a field strain of Musca domestica L.(Diptera: Muscidae)","volume":"130","author":"Khan","year":"2014","journal-title":"Acta Trop"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130537_bb0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/tox.21753","article-title":"Organic insecticide spinosad causes in vivo oxidative effects in the brain of Oreochromis niloticus","volume":"29","author":"Piner","year":"2014","journal-title":"Environ Toxicol"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130537_bb0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/pest.2001.2559","article-title":"Actions of insecticidal spinosyns on \u03b3-aminobutyric acid responses from small-diameter cockroach neurons","volume":"71","author":"Watson","year":"2001","journal-title":"Pestic Biochem Physiol"},{"issue":"9","key":"10.1016\/j.bmcl.2026.130537_bb0090","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1021\/acs.jnatprod.3c00276","article-title":"Spinosyn A and its derivative inhibit colorectal cancer cell growth via the EGFR pathway","volume":"86","author":"Peng","year":"2023","journal-title":"J Nat Prod"},{"issue":"9","key":"10.1016\/j.bmcl.2026.130537_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127047","article-title":"Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives","volume":"30","author":"Ma","year":"2020","journal-title":"Bioorg Med Chem Lett"},{"issue":"20","key":"10.1016\/j.bmcl.2026.130537_bb0100","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1016\/j.bmcl.2018.09.005","article-title":"Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives","volume":"28","author":"Ma","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130537_bb0105","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41467-021-22235-8","article-title":"Naturally-occurring spinosyn a and its derivatives function as argininosuccinate synthase activator and tumor inhibitor","volume":"12","author":"Zou","year":"2021","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.bmcl.2026.130537_bb0110","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000769","article-title":"ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance","volume":"9","author":"Ming","year":"2025","journal-title":"Hepatol Commun"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:18:39Z","timestamp":1770470319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":22,"alternative-id":["S0960894X26000041"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130537","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinosyn A derivatives as ASS1 activators and tumor inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130537"}}