{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:34:43Z","timestamp":1777883683406,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007935","name":"Hainan Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["20152023"],"award-info":[{"award-number":["20152023"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["2019RC229"],"award-info":[{"award-number":["2019RC229"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["XSTS2025182"],"award-info":[{"award-number":["XSTS2025182"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bmcl.2026.130548","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:23:38Z","timestamp":1768926218000},"page":"130548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design, synthesis and preliminary evaluation of mosquitoicidal activity of arecoline derivatives targeting muscarinic acetylcholine receptors"],"prefix":"10.1016","volume":"134","author":[{"given":"Hongyue","family":"Bu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Long","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cun-Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaolu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuojin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130548_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/5898160","article-title":"Nanoparticles: a potential and effective method to control Insect-borne diseases","volume":"2023","author":"Nie","year":"2023","journal-title":"Bioinorg Chem Appl"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130548_bb0010","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.mcna.2008.07.002","article-title":"Geographic expansion of dengue: the impact of international travel","volume":"92","author":"Wilder-Smith","year":"2008","journal-title":"Med Clin North Am"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130548_bb0015","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1089\/vbz.2011.0814","article-title":"A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options","volume":"12","author":"Medlock","year":"2012","journal-title":"Vector Borne Zoonotic Dis"},{"key":"10.1016\/j.bmcl.2026.130548_bb0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-ento-020117-043315","article-title":"Environmental adaptations, ecological filtering, and dispersal central to insect invasions","volume":"63","author":"Renault","year":"2018","journal-title":"Annu Rev Endemol"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130548_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pop.2018.05.001","article-title":"Mosquito-borne diseases","volume":"45","author":"Lee","year":"2018","journal-title":"Prim Care"},{"key":"10.1016\/j.bmcl.2026.130548_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.715759","article-title":"Emerging and re-emerging vector-borne infectious diseases and the challenges for control: a review","volume":"9","author":"Chala","year":"2021","journal-title":"Front Public Health"},{"key":"10.1016\/j.bmcl.2026.130548_bb0035","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fmicb.2019.00022","article-title":"Arbovirus-mosquito vector-host interactions and the impact on transmission and disease pathogenesis of arboviruses","volume":"10","author":"Huang","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmcl.2026.130548_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.ento.44.1.51","article-title":"Emerging and resurging vector-borne diseases","volume":"44","author":"Gratz","year":"1999","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.bmcl.2026.130548_bb0045","series-title":"Insecticides Resistance","first-page":"111","article-title":"Mosquito-borne diseases, pesticides used for mosquito control, and development of resistance to insecticides","author":"Cuervo-Parra","year":"2016"},{"key":"10.1016\/j.bmcl.2026.130548_bb0050","series-title":"Vector Biology, Ecology and Control","first-page":"39","article-title":"The global threat of emergent\/re-emergent vector-borne diseases","author":"Gubler","year":"2010"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130548_bb0055","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/ps.4044","article-title":"Control methods against invasive Aedes mosquitoes in Europe: a review","volume":"71","author":"Baldacchino","year":"2015","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmcl.2026.130548_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pestbp.2015.04.004","article-title":"The global status of insect resistance to neonicotinoid insecticides","volume":"121","author":"Bass","year":"2015","journal-title":"Pestic Biochem Physiol"},{"key":"10.1016\/j.bmcl.2026.130548_bb0065","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1186\/s12889-015-2199-y","article-title":"Meta-analysis of studies on chemical, physical and biological agents in the control of Aedes aegypti","volume":"15","author":"Lima","year":"2015","journal-title":"BMC Public Health"},{"key":"10.1016\/j.bmcl.2026.130548_bb0070","series-title":"Molecular Identification of Mosquito Vectors and their Management","first-page":"35","article-title":"Chemical methods for control of mosquito vector","author":"Shroff","year":"2021"},{"issue":"8","key":"10.1016\/j.bmcl.2026.130548_bb0075","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.3390\/molecules28083641","article-title":"The buzz on insecticides: a review of uses, molecular structures, targets, adverse effects, and alternatives","volume":"28","author":"Ara\u00fajo","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130548_bb0080","first-page":"3","article-title":"Mosquito control: a review on the past, present and future strategies","volume":"50","author":"Karunaratne","year":"2022","journal-title":"J Natl Sci Found Sri Lanka"},{"key":"10.1016\/j.bmcl.2026.130548_bb0085","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuro.2016.05.021","article-title":"Toxicology of potassium channel-directed compounds in mosquitoes","volume":"60","author":"Larson","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bmcl.2026.130548_bb0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cois.2019.12.001","article-title":"Effects of insecticide resistance and exposure on plasmodium development in Anopheles mosquitoes","volume":"39","author":"Minetti","year":"2020","journal-title":"Curr Opin Insect Sci"},{"key":"10.1016\/j.bmcl.2026.130548_bb0095","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pestbp.2014.11.014","article-title":"IRAC: mode of action classification and insecticide resistance management","volume":"121","author":"Sparks","year":"2015","journal-title":"Pestic Biochem Physiol"},{"key":"10.1016\/j.bmcl.2026.130548_bb0100","series-title":"Insect Molecular Biology and Biochemistry","first-page":"236","article-title":"Genes and P450 enzymes","author":"Feyereisen","year":"2012"},{"key":"10.1016\/j.bmcl.2026.130548_bb0105","series-title":"Medical and Veterinary Entomology","first-page":"261","article-title":"Mosquitoes (Culicidae)","author":"Foster","year":"2019"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130548_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007615","article-title":"Management of insecticide resistance in the major Aedes vectors of arboviruses: advances and challenges","volume":"13","author":"Dusfour","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.bmcl.2026.130548_bb0115","series-title":"Neurosciences-from Molecule to Behavior: A University Textbook","first-page":"19","article-title":"Evolution of nervous systems and brains","author":"Roth","year":"2013"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130548_bb0120","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0033583500001463","article-title":"Acetylcholine receptors","volume":"7","author":"Rang","year":"1974","journal-title":"Q Rev Biophys"},{"key":"10.1016\/j.bmcl.2026.130548_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/658918","article-title":"Muscarinic ACh receptors contribute to aversive olfactory learning in Drosophila","volume":"2015","author":"Silva","year":"2015","journal-title":"Neural Plast"},{"key":"10.1016\/j.bmcl.2026.130548_bb0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-ento-120811-153645","article-title":"Neuroactive insecticides: targets, selectivity, resistance, and secondary effects","volume":"58","author":"Casida","year":"2013","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.bmcl.2026.130548_bb0135","series-title":"Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control","first-page":"55","article-title":"Potential of GPCR-targeting insecticides for control of arthropod vectors","author":"Sharan","year":"2017"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130548_bb0140","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/ntr\/ntx187","article-title":"Cracking the betel nut: cholinergic activity of areca alkaloids and related compounds","volume":"21","author":"Horenstein","year":"2019","journal-title":"Nicotine Tob Res"},{"issue":"25","key":"10.1016\/j.bmcl.2026.130548_bb0145","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/S0024-3205(99)00188-5","article-title":"Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland","volume":"64","author":"Moriya","year":"1999","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130548_bb0150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1095-8339.2011.01199.x","article-title":"A monograph of the betel nut palms (Areca: Arecaceae) of east Malesia","volume":"168","author":"Heatubun","year":"2012","journal-title":"Bot J Linn Soc"},{"key":"10.1016\/j.bmcl.2026.130548_bb0155","series-title":"The Handbook of Mummy Studies: New Frontiers in Scientific and Cultural Perspectives","first-page":"513","article-title":"Ancient parasites seen in the archaeology and medical contexts in the Han dynasty, China","author":"Zhan","year":"2021"},{"key":"10.1016\/j.bmcl.2026.130548_bb0160","doi-asserted-by":"crossref","first-page":"1407212","DOI":"10.3389\/fphar.2024.1407212","article-title":"Comprehensive insights into Areca nut: active components and omics technologies for bioactivity evaluation and quality control","volume":"15","author":"Sun","year":"2024","journal-title":"Front Pharmacol"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130548_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260281","article-title":"Analysis of chemical compositions and larvicidal activity of nut extracts from Areca catechu Linn against Aedes (Diptera: Culicidae)","volume":"16","author":"Bharathithasan","year":"2021","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130548_bb0170","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.3109\/13880209.2016.1160251","article-title":"The pharmacology, toxicology and potential applications of arecoline: a review","volume":"54","author":"Liu","year":"2016","journal-title":"Pharm Biol"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130548_bb0175","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/ps.6222","article-title":"Widespread multiple insecticide resistance in the major dengue vector Aedes albopictus in Hainan Province","volume":"77","author":"Li","year":"2021","journal-title":"China Pest Manag Sci"},{"issue":"8","key":"10.1016\/j.bmcl.2026.130548_bb0180","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1002\/ps.6985","article-title":"Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities","volume":"78","author":"Che","year":"2022","journal-title":"Pest Manag Sci"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:54:32Z","timestamp":1777600472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26000156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S0960894X26000156"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130548","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and preliminary evaluation of mosquitoicidal activity of arecoline derivatives targeting muscarinic acetylcholine receptors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130548"}}