{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:58:09Z","timestamp":1793159889567,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20253BAC260015"],"award-info":[{"award-number":["20253BAC260015"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bmcl.2026.130613","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:19:31Z","timestamp":1772583571000},"page":"130613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis, and anti-necroptotic activity of novel Phenylbenzothiazole receptor-interacting protein kinase 1 (RIPK1) inhibitors"],"prefix":"10.1016","volume":"136","author":[{"given":"Jing","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houzong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bmcl.2026.130613_bb0005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130613_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/cdd.2011.164","article-title":"Many stimuli pull the necrotic trigger, an overview","volume":"19","author":"Vanlangenakker","year":"2012","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130613_bb0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-023-05691-6","article-title":"The double-edged functions of necroptosis","volume":"14","author":"Ye","year":"2023","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130613_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.trecan.2021.09.003","article-title":"Necroptosis and tumor progression","volume":"8","author":"Yan","year":"2022","journal-title":"Trends Cancer"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130613_bb0025","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.bmcl.2026.130613_bb0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130613_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130613_bb0040","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1021\/acs.jmedchem.9b01317","article-title":"Small-molecule inhibitors of necroptosis: current status and perspectives","volume":"63","author":"Zhuang","year":"2020","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130613_bb0045","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/med.21968","article-title":"Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions","volume":"43","author":"Xu","year":"2023","journal-title":"Med Res Rev"},{"issue":"6281","key":"10.1016\/j.bmcl.2026.130613_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf2154","article-title":"Programmed necrosis in inflammation: toward identification of the effector molecules","volume":"352","author":"Wallach","year":"2016","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.bmcl.2026.130613_bb0055","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.3206","article-title":"The diverse role of RIP kinases in necroptosis and inflammation","volume":"16","author":"Silke","year":"2015","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130613_bb0060","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1021\/acs.jmedchem.2c01621","article-title":"From (tool)bench to bedside: the potential of necroptosis inhibitors","volume":"66","author":"Gardner","year":"2023","journal-title":"J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2026.130613_bb0065","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.cclet.2021.09.059","article-title":"Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury","volume":"33","author":"Xu","year":"2022","journal-title":"Chin Chem Lett"},{"issue":"12","key":"10.1016\/j.bmcl.2026.130613_bb0070","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/bph.14653","article-title":"Identification of the raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3","volume":"176","author":"Chen","year":"2019","journal-title":"Br J Pharmacol"},{"issue":"14","key":"10.1016\/j.bmcl.2026.130613_bb0075","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1021\/acs.jmedchem.9b00611","volume":"62","author":"Zhang","year":"2019","journal-title":"J Med Chem"},{"issue":"22","key":"10.1016\/j.bmcl.2026.130613_bb0080","doi-asserted-by":"crossref","first-page":"15288","DOI":"10.1021\/acs.jmedchem.3c01351","article-title":"Insight from linker investigations: discovery of a novel phenylbenzothiazole necroptosis inhibitor targeting receptor-interacting protein kinase 1 (RIPK1) from a phenoxybenzothiazole compound with dual RIPK1\/3 targeting activity","volume":"66","author":"Fang","year":"2023","journal-title":"J Med Chem"},{"issue":"7","key":"10.1016\/j.bmcl.2026.130613_bb0085","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1021\/acs.jmedchem.3c00197","article-title":"Targeting receptor-interacting protein kinase 1 by novel benzothiazole derivatives: treatment of acute lung injury through the necroptosis pathway","volume":"66","author":"Zhang","year":"2023","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmcl.2026.130613_bb0090","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41573-020-0071-y","article-title":"Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target","volume":"19","author":"Mifflin","year":"2020","journal-title":"Nat Rev Drug Discov"},{"issue":"22","key":"10.1016\/j.bmcl.2026.130613_bb0095","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1016\/j.bmcl.2005.07.077","article-title":"Structure-activity relationship study of novel necroptosis inhibitors","volume":"15","author":"Teng","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130613_bb0100","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/acs.jmedchem.6b01751","article-title":"Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases","volume":"60","author":"Harris","year":"2017","journal-title":"J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2026.130613_bb0105","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1021\/acs.jmedchem.5b01898","article-title":"DNA-encoded library screening identifies benzo[b][1,4]oxazepin-4-ones as highly potent and monoselective receptor interacting protein 1 kinase inhibitors","volume":"59","author":"Harris","year":"2016","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130613_bb0110","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/acsmedchemlett.9b00108","article-title":"Identification of a RIP1 kinase inhibitor clinical candidate (GSK3145095) for the treatment of pancreatic cancer","volume":"10","author":"Harris","year":"2019","journal-title":"ACS Med Chem Lett"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130613_bb0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jointm.2024.07.003","article-title":"Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: a multicenter, randomized, double-blind, phase 1b trial","volume":"5","author":"Chavez-Tapia","year":"2025","journal-title":"J Intensive Med"},{"key":"10.1016\/j.bmcl.2026.130613_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116076","article-title":"Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine\/threonine-protein kinase 1 (RIPK1) inhibitors","volume":"265","author":"Zhang","year":"2024","journal-title":"Eur J Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130613_bb0125","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1021\/acs.jmedchem.6b01196","article-title":"Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome","volume":"60","author":"Ren","year":"2017","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130613_bb0130","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/acs.jmedchem.3c02102","article-title":"From hit to lead: structure-based optimization of novel selective inhibitors of receptor-interacting protein kinase 1 (RIPK1) for the treatment of inflammatory diseases","volume":"67","author":"Zhang","year":"2024","journal-title":"J Med Chem"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130613_bb0135","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.apsb.2021.05.017","article-title":"Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy","volume":"11","author":"Zhu","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"5","key":"10.1016\/j.bmcl.2026.130613_bb0140","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s10753-023-01842-1","article-title":"Protective effect of a novel RIPK1 inhibitor, compound 4\u2013155, in systemic inflammatory response syndrome and sepsis","volume":"46","author":"Ling","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.bmcl.2026.130613_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106647","article-title":"Analysis on benzothiazole necroptosis inhibitors with chiral substitutions in the solvent-accessible region of RIP kinase domain","volume":"137","author":"Shao","year":"2023","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2026.130613_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106339","article-title":"Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors","volume":"131","author":"Xu","year":"2023","journal-title":"Bioorg Chem"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130613_bb0155","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1021\/acs.jmedchem.2c02067","article-title":"Structure-based design of novel alkynyl thio-benzoxazepinone receptor-interacting protein kinase-1 inhibitors: extending the chemical space from the allosteric to ATP binding pockets","volume":"66","author":"Quan","year":"2023","journal-title":"J Med Chem"},{"issue":"21","key":"10.1016\/j.bmcl.2026.130613_bb0160","doi-asserted-by":"crossref","first-page":"14957","DOI":"10.1021\/acs.jmedchem.2c01478","article-title":"Discovery of a trifluoromethoxy cyclopentanone benzothiazole receptor-interacting protein kinase 1 inhibitor as the treatment for alzheimer\u2019s disease","volume":"65","author":"Sun","year":"2022","journal-title":"J Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:30:54Z","timestamp":1774974654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26000806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S0960894X26000806"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130613","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and anti-necroptotic activity of novel Phenylbenzothiazole receptor-interacting protein kinase 1 (RIPK1) inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130613"}}