{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:59:18Z","timestamp":1793213958667,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007547","name":"Fourth Military Medical University","doi-asserted-by":"publisher","award":["2024JC052"],"award-info":[{"award-number":["2024JC052"]}],"id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373733"],"award-info":[{"award-number":["82373733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["2025GH-YBXM-004"],"award-info":[{"award-number":["2025GH-YBXM-004"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bmcl.2026.130620","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:08:38Z","timestamp":1773126518000},"page":"130620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Design, synthesis, and biological evaluation of pyridine\u2013triazole derivatives as URAT1 inhibitors with potential application in hyperuricemia and gout"],"prefix":"10.1016","volume":"136","author":[{"given":"Yujiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muqiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130620_bb0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2459\/JCM.0b013e3283595adc","article-title":"Hyperuricaemia: more than just a cause of gout?","volume":"14","author":"Katsiki","year":"2013","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.bmcl.2026.130620_bb0010","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2741\/3950","article-title":"Uric acid, hyperuricemia and vascular diseases","volume":"17","author":"Jin","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.bmcl.2026.130620_bb0015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41392-024-01916-y","article-title":"Hyperuricemia and its related diseases: mechanisms and advances in therapy","volume":"9","author":"Du","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bmcl.2026.130620_bb0020","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/rheumatology\/kez196","article-title":"Gout and hyperuricaemia in the USA: prevalence and trends","volume":"58","author":"Singh","year":"2019","journal-title":"Rheumatology (Oxf)"},{"key":"10.1016\/j.bmcl.2026.130620_bb0025","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1097\/CM9.0000000000003631","article-title":"Global burden and trends of gout incidence and prevalence","volume":"138","author":"Jin","year":"2025","journal-title":"Chin Med J"},{"key":"10.1016\/j.bmcl.2026.130620_bb0030","article-title":"The disease burden of gout in Asian countries and regions from 1990 to 2021, risk factors and forecast analysis: a systematic study of Asian disease burden in 2021","volume":"20","author":"Yang","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2026.130620_bb0035","doi-asserted-by":"crossref","unstructured":"Takata T, Mae Y, Hoi S, Iyama T, Isomoto H. Hyperuricemia in chronic kidney disease: emerging pathophysiology and a novel therapeutic strategy. In Int J Mol Sci, 2025; Vol. 26, p 9000.","DOI":"10.3390\/ijms26189000"},{"key":"10.1016\/j.bmcl.2026.130620_bb0040","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1038\/s41467-025-61226-x","article-title":"Molecular mechanism of drug inhibition of URAT1","volume":"16","author":"Yu","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2026.130620_bb0045","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1021\/acs.jmedchem.3c01710","article-title":"Agents for the treatment of gout: current advances and future perspectives","volume":"66","author":"Zeng","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116327","article-title":"Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities","volume":"269","author":"Li","year":"2024","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0055","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1021\/acs.jmedchem.4c00136","article-title":"Discovery of a novel Thienopyrimidine compound as a urate transporter 1 and glucose transporter 9 dual inhibitor with improved efficacy and Favorable Druggability","volume":"67","author":"Shi","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0060","doi-asserted-by":"crossref","first-page":"19966","DOI":"10.1021\/acs.jmedchem.4c01260","article-title":"Recent Progress and future perspectives on anti-Hyperuricemic agents","volume":"67","author":"Sun","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0065","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1021\/acs.jmedchem.4c01480","article-title":"Discovery of a potent and orally bioavailable xanthine oxidase\/urate transporter 1 dual inhibitor as a potential treatment for hyperuricemia and gout","volume":"67","author":"Yang","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0070","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/acs.jmedchem.4c02717","article-title":"Recent Progress in the development of glucose transporter (GLUT) inhibitors","volume":"68","author":"Wang","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0075","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1021\/acsmedchemlett.0c00176","article-title":"Discovery of Dotinurad (FYU-981), a new phenol derivative with highly potent uric acid lowering activity","volume":"11","author":"Uda","year":"2020","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130620_bb0080","doi-asserted-by":"crossref","unstructured":"Herdiana Y, Wardhana YW, Kurniawansyah IS, Gozali D, Wathoni N, Sofian FF. Current status of gout arthritis: current approaches to gout arthritis treatment: nanoparticles delivery systems approach Pharmaceutics 2025;17.","DOI":"10.3390\/pharmaceutics17010102"},{"key":"10.1016\/j.bmcl.2026.130620_bb0085","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1021\/tx7001228","article-title":"Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol intermediate","volume":"20","author":"McDonald","year":"2007","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.bmcl.2026.130620_bb0090","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.bmcl.2018.10.023","article-title":"Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation","volume":"28","author":"Ohe","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130620_bb0095","doi-asserted-by":"crossref","first-page":"20903","DOI":"10.1021\/acs.jmedchem.5c01100","article-title":"Scaffold hopping in tuberculosis drug discovery: principles, applications, and case studies","volume":"68","author":"Kovar","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0100","doi-asserted-by":"crossref","unstructured":"Shivani, Abdul Rahaman TA, Chaudhary S. Targeting cancer using scaffold-hopping approaches: illuminating SAR to improve drug design. Drug Discov Today 2024;29:104115.","DOI":"10.1016\/j.drudis.2024.104115"},{"key":"10.1016\/j.bmcl.2026.130620_bb0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejmech.2017.08.047","article-title":"Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors","volume":"140","author":"Li","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0110","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.1021\/acs.jmedchem.0c00223","article-title":"Novel human urate transporter 1 inhibitors as hypouricemic drug candidates with Favorable Druggability","volume":"63","author":"Zhao","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0115","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1021\/acs.jmedchem.1c02057","article-title":"Discovery of novel bicyclic Imidazolopyridine-containing human urate transporter 1 inhibitors as hypouricemic drug candidates with improved efficacy and Favorable Druggability","volume":"65","author":"Zhao","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41421-025-00779-z","article-title":"Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs","volume":"11","author":"Wu","year":"2025","journal-title":"Cell Discov"},{"key":"10.1016\/j.bmcl.2026.130620_bb0125","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.12998\/wjcc.v7.i13.1717","article-title":"Liver failure associated with benzbromarone: a case report and review of the literature","volume":"7","author":"Zhang","year":"2019","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.bmcl.2026.130620_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106401","article-title":"Inspired by bis-\u03b2-carboline alkaloids: construction and antitumor evaluation of a novel bis-\u03b2-carboline scaffold as potent antitumor agents","volume":"133","author":"Liu","year":"2023","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0135","doi-asserted-by":"crossref","first-page":"8066","DOI":"10.1021\/acs.jmedchem.3c00396","article-title":"Discovery of platinum(IV)-artesunate multiaction prodrugs as potent antitumor and antimalarial agents","volume":"66","author":"Liu","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0140","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1021\/acs.jmedchem.4c00784","article-title":"Discovery of novel p53-MDM2 inhibitor (RG7388)-conjugated platinum(IV) complexes as potent antitumor agents","volume":"67","author":"Liu","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108312","article-title":"Design, synthesis, and biological evaluation of novel artemisinin-based HDAC inhibitors with antitumor and antimalarial activities","volume":"157","author":"He","year":"2025","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.130082","article-title":"Discovery of 3-amide-pyrimidine-based derivatives as potential fms-like tyrosine receptor kinase 3 (FLT3) inhibitors for treating acute myelogenous leukemia","volume":"117","author":"Liu","year":"2025","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130620_bb0155","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1021\/acs.jmedchem.6c00138","article-title":"Discovery of potent HDAC6-selective inhibitors based on artemisinin: design, synthesis, and antitumor evaluation","volume":"69","author":"Liu","year":"2026","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130620_bb0160","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1186\/s12882-025-04414-7","article-title":"Hyperuricemia-induced kidney injury: a narrative review of mechanisms and therapeutic advances","volume":"26","author":"Zhang","year":"2025","journal-title":"BMC Nephrol"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:31:32Z","timestamp":1774974692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S0960894X26000879"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130620","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of pyridine\u2013triazole derivatives as URAT1 inhibitors with potential application in hyperuricemia and gout","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130620"}}