{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:20:18Z","timestamp":1777890018538,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,11]],"date-time":"2027-04-11T00:00:00Z","timestamp":1807401600000},"content-version":"am","delay-in-days":253,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3AR083022"],"award-info":[{"award-number":["UG3AR083022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bmcl.2026.130653","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:49:11Z","timestamp":1775720951000},"page":"130653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as potential anti-inflammatory agents and antidotes for arsenicals"],"prefix":"10.1016","volume":"137","author":[{"given":"Omar","family":"Moukha-Chafiq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Fosso","family":"Yatchang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn","family":"Houghtling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahlia","family":"Cantor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Tillotson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarath C.","family":"Sarngadharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad","family":"Al Abir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Vinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupam","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Athar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne E.","family":"Augelli-Szafran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130653_bb0005","series-title":"Medical Aspects of Chemical Warfare","first-page":"259","article-title":"Vesicants","author":"Gurst","year":"2008"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/srep34865","article-title":"Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype","volume":"6","author":"Srivastava","year":"2016","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130653_bb0015","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/j.ajpath.2016.06.012","article-title":"Molecular mechanism underlying pathogenesis of lewisite-induced cutaneous blistering and inflammation: chemical chaperones as potential novel antidotes","volume":"186","author":"Li","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bmcl.2026.130653_bb0020","series-title":"History of Modern Clinical Toxicology","first-page":"243","article-title":"Chapter 3.4 - British anti-lewisite (dimercaprol)","author":"Hauptman","year":"2022"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/nyas.13214","article-title":"Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals","volume":"1378","author":"Li","year":"2016","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/nyas.14475","article-title":"Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals","volume":"1480","author":"Srivastava","year":"2020","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130653_bb0035","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147564","article-title":"Netosis in the pathogenesis of acute lung injury following cutaneous chemical burns","volume":"6","author":"Surolia","year":"2021","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0040","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1038\/s41598-024-83513-1","article-title":"Common molecular profile of multiple structurally distinct warfare arsenicals in causing cutaneous chemical vesicant injury","volume":"15","author":"Srivastava","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/nyas.14809","article-title":"Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage","volume":"1515","author":"Srivastava","year":"2022","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bmcl.2026.130653_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128696","article-title":"Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals","volume":"64","author":"Yatchang","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130653_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.slasd.2025.100247","article-title":"High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals","volume":"35","author":"Yatchang","year":"2025","journal-title":"SLAS Discov"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130653_bb0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.tcb.2014.09.005","article-title":"Brd4 is on the move during inflammation","volume":"24","author":"Xu","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130653_bb0065","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.ddstr.2011.12.002","article-title":"Bromodomains: a new target class for small molecule drug discovery","volume":"9","author":"Chung","year":"2012","journal-title":"Drug Discov Today Ther Strateg"},{"issue":"7327","key":"10.1016\/j.bmcl.2026.130653_bb0070","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature09589","article-title":"Suppression of inflammation by a synthetic histone mimic","volume":"468","author":"Nicodeme","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41420-024-01957-w","article-title":"RIPK3 signaling and its role in regulated cell death and diseases","volume":"10","author":"Zhou","year":"2024","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130653_bb0080","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1038\/s41467-021-27032-x","article-title":"Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis","volume":"12","author":"Meng","year":"2021","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130653_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/pro.5191","article-title":"Enhanced cellular death in liver and breast cancer cells by dual BET\/BRPF1 inhibitors","volume":"33","author":"Cazzanelli","year":"2024","journal-title":"Protein Sci"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130653_bb0090","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1021\/acschembio.3c00427","article-title":"Development of potent dual BET\/HDAC inhibitors via pharmacophore merging and structure-guided optimization","volume":"19","author":"Bauer","year":"2024","journal-title":"ACS Chem Biol"},{"issue":"22","key":"10.1016\/j.bmcl.2026.130653_bb0095","doi-asserted-by":"crossref","first-page":"15416","DOI":"10.1021\/acs.jmedchem.2c01357","article-title":"Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLiteshalogenated probes of druglike and peptide-like molecular interactions","volume":"65","author":"Davison","year":"2022","journal-title":"J Med Chem"},{"issue":"14","key":"10.1016\/j.bmcl.2026.130653_bb0100","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.1021\/acs.jmedchem.1c00933","article-title":"4-Methyl-1,2,3-triazoles as N-acetyl-lysine mimics afford potent BET bromodomain inhibitors with improved selectivity","volume":"64","author":"Cui","year":"2021","journal-title":"J Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26001204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26001204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:25:02Z","timestamp":1777613102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26001204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"alternative-id":["S0960894X26001204"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130653","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as potential anti-inflammatory agents and antidotes for arsenicals","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130653"}}