{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:25:49Z","timestamp":1785864349813,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bmcl.2026.130735","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:42:53Z","timestamp":1784097773000},"page":"130735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hexadentate 3-hydroxypyridin-4(1H)-ones as dual biofilm inhibition and dispersion agents against Pseudomonas aeruginosa potentiate ciprofloxacin activity"],"prefix":"10.1016","volume":"140","author":[{"given":"Yuan-Yuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Tong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Zhang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130735_bb0005","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41579-019-0293-3","article-title":"Antibiotic development-economic, regulatory and societal challenges","volume":"18","author":"\u00c5rdal","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bmcl.2026.130735_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2023.100030","article-title":"Phage therapy as a revolutionary treatment for multidrug-resistant Pseudomonas aeruginosa infections: a narrative review","volume":"2","author":"Nawaz","year":"2024","journal-title":"Microbe"},{"key":"10.1016\/j.bmcl.2026.130735_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118115","article-title":"Optimizing biofilm inhibitors: balancing activity and toxicity in 2N-aminated 5-aryl-2-aminoimidazoles","volume":"121","author":"Maetens","year":"2025","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrd1008","article-title":"Understanding biofilm resistance to antibacterial agents","volume":"2","author":"Davies","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmcl.2026.130735_bb0025","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature02122","article-title":"A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance","volume":"426","author":"Mah","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2026.130735_bb0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.clpt.6100247","article-title":"The challenge of treating biofilm-associated bacterial infections","volume":"82","author":"Del Pozo","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.bmcl.2026.130735_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/biom16020197","article-title":"Bioinformatics-driven, plant-based antibiotic research against quorum sensing and biofilm formation in Pseudomonas aeruginosa and Escherichia coli multiresistant microbes","volume":"16","author":"Rosignoli","year":"2026","journal-title":"Biomolecules"},{"key":"10.1016\/j.bmcl.2026.130735_bb0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/MMBR.05007-11","article-title":"The multiple signaling systems regulating virulence in Pseudomonas aeruginosa","volume":"76","author":"Nadal Jimenez","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.bmcl.2026.130735_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118496","article-title":"Peptide-based approaches to quorum-sensing disruption: emerging trends and applications in antimicrobial therapy","volume":"133","author":"Khan","year":"2026","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0050","doi-asserted-by":"crossref","first-page":"E9411","DOI":"10.1073\/pnas.1814023115","article-title":"The PqsE and RhlR proteins are an autoinducer synthase\u2013receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa","volume":"115","author":"Mukherjee","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmcl.2026.130735_bb0055","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/acsinfecdis.5c01128","article-title":"Quinazolinone-based PqsR modulators suppress quorum-sensing-driven virulence in Pseudomonas aeruginosa","volume":"12","author":"Tudino","year":"2026","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmcl.2026.130735_bb0060","article-title":"RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes in Pseudomonas aeruginosa","volume":"0","author":"Pope","year":"2026","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0065","doi-asserted-by":"crossref","first-page":"107649","DOI":"10.1016\/j.bioorg.2024.107649","article-title":"Critical review on plant-derived quorum sensing signaling inhibitors in Pseudomonas aeruginosa","volume":"151","author":"Vadakkan","year":"2024","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0070","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1073\/pnas.0504266102","article-title":"Iron and Pseudomonas aeruginosa biofilm formation","volume":"102","author":"Banin","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2026.130735_bb0075","article-title":"The mono (catecholamine) derivatives as iron chelators: synthesis, solution thermodynamic stability and antioxidant properties research","volume":"5","author":"Zhang","year":"2018","journal-title":"R Soc Open Sci"},{"key":"10.1016\/j.bmcl.2026.130735_bb0080","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/acs.accounts.3c00814","article-title":"Exploring the antibacterial activity and cellular fates of enterobactin\u2013drug conjugates that target gram-negative bacterial pathogens","volume":"57","author":"Guo","year":"2024","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.bmcl.2026.130735_bb0085","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1021\/jacs.8b01042","article-title":"Esterase-catalyzed siderophore hydrolysis activates an enterobactin\u2013ciprofloxacin conjugate and confers targeted antibacterial activity","volume":"140","author":"Neumann","year":"2018","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2026.130735_bb0090","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/1462-2920.16328","article-title":"Pseudomonas aeruginosa and its multiple strategies to access iron","volume":"25","author":"Schalk","year":"2023","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0095","article-title":"PQS and pyochelin in Pseudomonas aeruginosa share inner membrane transporters to mediate iron uptake","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.bmcl.2026.130735_bb0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/1061186X.2020.1824235","article-title":"Iron metabolism in Pseudomonas aeruginosa biofilm and the involved iron-targeted anti-biofilm strategies","volume":"29","author":"Zhang","year":"2021","journal-title":"J Drug Target"},{"key":"10.1016\/j.bmcl.2026.130735_bb0105","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.3390\/ijms22062876","article-title":"Recent advances in iron chelation and gallium-based therapies for antibiotic resistant bacterial infections","volume":"22","author":"Vinuesa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2026.130735_bb0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/417552a","article-title":"A component of innate immunity prevents bacterial biofilm development","volume":"417","author":"Singh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2026.130735_bb0115","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1073\/pnas.1516979113","article-title":"Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity","volume":"113","author":"Hendricks","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2026.130735_bb0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jbm.a.10493","article-title":"The inhibitory activity of serum to prevent bacterial adhesion is mainly due to apo-transferrin","volume":"66A","author":"Ardehali","year":"2003","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.bmcl.2026.130735_bb0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1165\/rcmb.2008-0299OC","article-title":"Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells","volume":"41","author":"Moreau-Marquis","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0130","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1099\/jmm.0.004416-0","article-title":"Iron-binding compounds impair Pseudomonas aeruginosa biofilm formation, especially under anaerobic conditions","volume":"58","author":"O\u2019May","year":"2009","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0135","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1021\/acs.jmedchem.9b00481","article-title":"Glycocluster tetrahydroxamic acids exhibiting unprecedented inhibition of Pseudomonas aeruginosa biofilms","volume":"62","author":"Taouai","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0140","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1021\/acs.jmedchem.0c00763","article-title":"Novel 2-substituted 3-hydroxy-1, 6-dimethylpyridin-4 (1H)-ones as dual-acting biofilm inhibitors of Pseudomonas aeruginosa","volume":"63","author":"Liu","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0145","article-title":"Docking studies, antimicrobial activity, and structure-activity relationships of kojic acid derivatives","volume":"15","author":"Wang","year":"2026","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmcl.2026.130735_bb0150","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/acs.jmedchem.2c02044","article-title":"Design and synthesis of 3-hydroxy-pyridin-4 (1 H)-ones\u2013ciprofloxacin conjugates as dual antibacterial and antibiofilm agents against Pseudomonas aeruginosa","volume":"66","author":"Wang","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0155","doi-asserted-by":"crossref","first-page":"8920","DOI":"10.1021\/ja062046j","article-title":"Enterobactin protonation and iron release: structural characterization of the salicylate coordination shift in ferric enterobactin1","volume":"128","author":"Abergel","year":"2006","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2026.130735_bb0160","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1021\/acs.jmedchem.1c00749","article-title":"Starving bacteria of iron: a potential strategy to disperse bacterial biofilms","volume":"64","author":"Naclerio","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0165","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1128\/AEM.72.3.2064-2069.2006","article-title":"Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm","volume":"72","author":"Banin","year":"2006","journal-title":"Appl Environ Microb"},{"issue":"51","key":"10.1016\/j.bmcl.2026.130735_bb0170","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1039\/C8CC03856B","article-title":"Dehydroxylation of alcohols for nucleophilic substitution","volume":"54","author":"Chen","year":"2018","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmcl.2026.130735_bb0175","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/pol.20200287","article-title":"Efficient synthesis of branched poly (acrylic acid) derivatives via postpolymerization modification","volume":"58","author":"Bou Zerdan","year":"2020","journal-title":"J Polym Sci"},{"key":"10.1016\/j.bmcl.2026.130735_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117396","article-title":"Discovery of 3-hydroxypyridin-4 (1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa","volume":"289","author":"Wang","year":"2025","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0185","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41579-020-0385-0","article-title":"Biofilm dispersion","volume":"18","author":"Rumbaugh","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0190","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1021\/jm2001019","article-title":"Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone","volume":"54","author":"Jadhav","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev-micro-092412-155635","article-title":"Acyl-homoserine lactone quorum sensing: from evolution to application","volume":"67","author":"Schuster","year":"2013","journal-title":"Ann Rev Microbiol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0200","doi-asserted-by":"crossref","first-page":"17981","DOI":"10.1073\/pnas.1316981110","article-title":"A quorum-sensing inhibitor blocks <i>Pseudomonas aeruginosa<\/i> virulence and biofilm formation","volume":"110","author":"O\u2019Loughlin","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2026.130735_bb0205","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1128\/AAC.00955-13","article-title":"Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database","volume":"57","author":"Tan","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2026.130735_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003508","article-title":"Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR)","volume":"9","author":"Ilangovan","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmcl.2026.130735_bb0215","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1021\/acsinfecdis.4c00287","article-title":"Exploring the localization of siderophore-mediated cargo delivery in gram-negative bacteria using 3-hydroxypyridin-4 (1 H)-one-fluorescein probes","volume":"10","author":"Huang","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bmcl.2026.130735_bb0220","doi-asserted-by":"crossref","first-page":"15285","DOI":"10.1021\/acs.jmedchem.5c01023","article-title":"Iron uptake systems: chemical tools for advancing infectious disease treatment and diagnosis","volume":"68","author":"Ni","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2958.2003.03288.x","article-title":"Siderophore-mediated cell signalling in Pseudomonas aeruginosa: divergent pathways regulate virulence factor production and siderophore receptor synthesis","volume":"47","author":"Beare","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.bmcl.2026.130735_bb0230","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1021\/acs.jmedchem.5b01698","article-title":"Novel strategies for the treatment of Pseudomonas aeruginosa infections","volume":"59","author":"Wagner","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130735_bb0235","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.chom.2013.03.003","article-title":"Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death","volume":"13","author":"Kirienko","year":"2013","journal-title":"Cell Host Microbe"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:21:06Z","timestamp":1785860466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26002027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0960894X26002027"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130735","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hexadentate 3-hydroxypyridin-4(1H)-ones as dual biofilm inhibition and dispersion agents against Pseudomonas aeruginosa potentiate ciprofloxacin activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130735","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130735"}}