{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:19Z","timestamp":1792068859109,"version":"4.4.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003489","name":"Henan University of Technology","doi-asserted-by":"publisher","award":["31401768"],"award-info":[{"award-number":["31401768"]}],"id":[{"id":"10.13039\/501100003489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bmcl.2026.130763","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:30:24Z","timestamp":1788305424000},"page":"130763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reactivation of an inert 15-mer antimicrobial peptide by truncation-directed i, i\u00a0+\u00a07 lactam cyclization"],"prefix":"10.1016","volume":"142","author":[{"given":"Jinhua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guancheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130763_bb0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0140-6736(24)02081-6","article-title":"Multidrug-resistant Gram-negative bacterial infections","volume":"405","author":"Macesic","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2026.130763_bb0010","unstructured":"Global antibiotic resistance surveillance report 2025. World Health Organization, 2025-11-14."},{"issue":"11","key":"10.1016\/j.bmcl.2026.130763_bb0015","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41579-025-01200-y","article-title":"Antimicrobial peptides: structure, functions and translational applications","volume":"23","author":"Oliveira J\u00fanior","year":"2025","journal-title":"Nat Rev Microbiol"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130763_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13112574","article-title":"Antimicrobial peptides: current status, mechanisms of action, and strategies to overcome therapeutic limitations","volume":"13","author":"Kim","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.bmcl.2026.130763_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00436-022-07674-6","article-title":"The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis","volume":"121","author":"Ram\u00edrez-Ledesma","year":"2022","journal-title":"Parasitol Res"},{"issue":"3","key":"10.1016\/j.bmcl.2026.130763_bb0030","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.7150\/thno.39157","article-title":"Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria","volume":"10","author":"Ma","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bmcl.2026.130763_bb0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s12602-023-10066-6","article-title":"The synthetic antimicrobial peptide derived from melittin displays low toxicity and anti-infectious properties","volume":"16","author":"Mansouri Rad","year":"2024","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.bmcl.2026.130763_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2026.109903","article-title":"The discovery of novel antimicrobial peptides against multidrug-resistant bacteria based on thioether cyclization and unnatural amino acid incorporation strategies","volume":"177","author":"Zeng","year":"2026","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2026.130763_bb0045","article-title":"Rational design and N-terminal acylation of a lactam-cyclized 11-residue antimicrobial peptide for improved antibacterial potency","author":"Zhang","year":"2026","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130763_bb0050","doi-asserted-by":"crossref","first-page":"19288","DOI":"10.1039\/D5SC06369H","article-title":"\u03b2-Lactamase cleavable antimicrobial peptide-drug conjugates","volume":"16","author":"Deingruber","year":"2025","journal-title":"Chem Sci"},{"issue":"24","key":"10.1016\/j.bmcl.2026.130763_bb0055","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.1016\/j.bmcl.2013.10.031","article-title":"Truncated and constrained helical analogs of antimicrobial esculentin-2EM","volume":"23","author":"Pham","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"issue":"18","key":"10.1016\/j.bmcl.2026.130763_bb0060","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/bioinformatics\/btn392","article-title":"HELIQUEST: a web server to screen sequences with specific alpha-helical properties","volume":"24","author":"Gautier","year":"2008","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130763_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00726-017-2516-0","article-title":"Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation","volume":"50","author":"Jaradat","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.bmcl.2026.130763_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3352","article-title":"The first total synthesis of the cyclodepsipeptide pipecolidepsin a","volume":"4","author":"Pelay-Gimeno","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2026.130763_bb0075","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2024"},{"key":"10.1016\/j.bmcl.2026.130763_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113104","article-title":"Design, synthesis and biological evaluation of a novel N-aminoacyl derivative of amphotericin B methyl ester as an antifungal agent","volume":"211","author":"Zhang","year":"2021","journal-title":"Eur J Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:01Z","timestamp":1792067701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26002301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":16,"alternative-id":["S0960894X26002301"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130763","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactivation of an inert 15-mer antimicrobial peptide by truncation-directed i, i\u00a0+\u00a07 lactam cyclization","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130763"}}