{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:26Z","timestamp":1792068866582,"version":"4.4.0"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bmcl.2026.130784","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:53:13Z","timestamp":1790610793000},"page":"130784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of potent GPR120 activators with fatty orosensation enhancement activity"],"prefix":"10.1016","volume":"142","author":[{"given":"Yayoi","family":"Kawato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotoe","family":"Nakasha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2026.130784_bb0005","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despres","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2026.130784_bb0010","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1021\/jm800970b","article-title":"Identification of G protein-coupled receptor 120-selective agonists derived from PPAR\u03b3 agonists","volume":"51","author":"Suzuki","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130784_bb0015","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1021\/jm300215x","article-title":"Discovery of a potent and selective GPR120 agonist","volume":"55","author":"Shimpukade","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130784_bb0020","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1523\/JNEUROSCI.0496-10.2010","article-title":"Taste preference for fatty acids is mediated by GPR40 and GPR120","volume":"30","author":"Cartoni","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmcl.2026.130784_bb0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1194\/jlr.RA119000142","article-title":"Novel GPR120 agonist TUG-891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice","volume":"61","author":"Murtaza","year":"2020","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bmcl.2026.130784_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113383","article-title":"GPR120 agonists enhance the fatty orosensation when added to fat-containing system, but do not evoke it by themselves in humans","volume":"234","author":"Iwasaki","year":"2021","journal-title":"Physiol Behav"},{"key":"10.1016\/j.bmcl.2026.130784_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2021.105219","article-title":"Effects of the potent GPR120 agonist, TUG-891, on sensory characteristics of whipped cream","volume":"125","author":"Iwasaki","year":"2022","journal-title":"Int Dairy J"},{"key":"10.1016\/j.bmcl.2026.130784_bb0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4327\/jsnfs1949.35.375","article-title":"Oxidation products of unsaturated fatty acids","volume":"35","author":"Matsushita","year":"1982","journal-title":"Eiyo to Shokuryo"},{"key":"10.1016\/j.bmcl.2026.130784_bb0045","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1080\/10408398.2019.1575792","article-title":"Deep-fried flavor: characteristics, formation mechanisms, and influencing factors","volume":"60","author":"Chang","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.bmcl.2026.130784_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-1981-29317","article-title":"The use of diethyl azodicarboxylate and triphenylphosphine in synthesis and transformation of natural products","author":"Mitsunobu","year":"1981","journal-title":"Synthesis"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:36:08Z","timestamp":1792067768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26002519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":10,"alternative-id":["S0960894X26002519"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130784","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of potent GPR120 activators with fatty orosensation enhancement activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130784"}}