{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:55:05Z","timestamp":1792068905002,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,10,1]],"date-time":"2027-10-01T00:00:00Z","timestamp":1822348800000},"content-version":"am","delay-in-days":273,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK137181"],"award-info":[{"award-number":["R01 DK137181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bmcl.2026.130787","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:52:20Z","timestamp":1790463140000},"page":"130787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors"],"prefix":"10.1016","volume":"142","author":[{"given":"Mario","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deija J.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugesh","family":"Kharel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey D.","family":"Prendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Webster L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bmcl.2026.130787_bb0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"20","key":"10.1016\/j.bmcl.2026.130787_bb0010","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1016\/j.tet.2005.02.075","article-title":"Chemistry and biology of sphingolipids","volume":"61","author":"Liao","year":"2005","journal-title":"Tetrahedron"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130787_bb0015","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tcb.2005.04.006","article-title":"The ins and outs of sphingolipid synthesis","volume":"15","author":"Futerman","year":"2005","journal-title":"Trends Cell Biol"},{"issue":"5","key":"10.1016\/j.bmcl.2026.130787_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12836","article-title":"Sphingosine-1-phosphate receptors and innate immunity","volume":"20","author":"Bryan","year":"2018","journal-title":"Cell Microbiol"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130787_bb0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1242\/dev.094805","article-title":"Sphingosine 1-phosphate signalling","volume":"141","author":"Mendelson","year":"2014","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130787_bb0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis \u2013 a review","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur J Neurol"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130787_bb0035","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: a review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.bmcl.2026.130787_bb0040","first-page":"1","article-title":"Sphingosine-1-phosphate signaling in immune cells and inflammation: roles and therapeutic potential","volume":"2016","author":"Aoki","year":"2016","journal-title":"Mediat Inflamm"},{"issue":"7","key":"10.1016\/j.bmcl.2026.130787_bb0045","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s40263-015-0261-z","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis","volume":"29","author":"Subei","year":"2015","journal-title":"CNS Drugs"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130787_bb0050","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130787_bb0055","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/acn3.52017","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: a practical review","volume":"11","author":"Coyle","year":"2024","journal-title":"Ann Clin Transl Neurol"},{"issue":"12","key":"10.1016\/j.bmcl.2026.130787_bb0060","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1016\/j.cell.2023.04.028","article-title":"Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate","volume":"186","author":"Chen","year":"2023","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130787_bb0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41422-023-00908-x","article-title":"Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport","volume":"34","author":"Pang","year":"2023","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130787_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-71659-7","article-title":"SPNS2 exports sphingosine-1-phosphate and imports glucose","volume":"17","author":"Weigel","year":"2026","journal-title":"Nat Commun"},{"issue":"22","key":"10.1016\/j.bmcl.2026.130787_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay8627","article-title":"Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier","volume":"6","author":"Wang","year":"2020","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.bmcl.2026.130787_bb0080","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s12964-024-01859-5","article-title":"Spinster homolog 2 (SPNS2) deficiency drives endothelial cell senescence and vascular aging via promoting pyruvate metabolism mediated mitochondrial dysfunction","volume":"22","author":"Tang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.bmcl.2026.130787_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.682773","article-title":"SPNS2 downregulation induces EMT and promotes colorectal cancer metastasis via activating AKT signaling pathway","volume":"11","author":"Lv","year":"2021","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.bmcl.2026.130787_bb0090","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s12011-022-03296-2","article-title":"Iron deficiency increases phosphorylation of SP1 to upregulate SPNS2 expression in hepatocellular carcinoma","volume":"201","author":"Wang","year":"2023","journal-title":"Biol Trace Elem Res"},{"issue":"10","key":"10.1016\/j.bmcl.2026.130787_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110119","article-title":"Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration","volume":"9","author":"Bradley","year":"2014","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.bmcl.2026.130787_bb0100","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1111\/bph.17456","article-title":"Assessment of spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target","volume":"182","author":"Kharel","year":"2025","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130787_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038941","article-title":"Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells","volume":"7","author":"Hisano","year":"2012","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.bmcl.2026.130787_bb0110","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1096\/fj.15-274936","article-title":"Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases","volume":"29","author":"Donoviel","year":"2015","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130787_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109368","article-title":"SPNS2 enables T cell egress from lymph nodes during an immune response","volume":"36","author":"Okuniewska","year":"2021","journal-title":"Cell Rep"},{"issue":"658","key":"10.1016\/j.bmcl.2026.130787_bb0120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj2681","article-title":"Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney","volume":"14","author":"Tanaka","year":"2022","journal-title":"Sci Transl Med"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130787_bb0125","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1021\/acs.jmedchem.1c02171","article-title":"Discovery of in vivo active Sphingosine-1-phosphate transporter (Spns2) inhibitors","volume":"65","author":"Fritzemeier","year":"2022","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmcl.2026.130787_bb0130","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1021\/acs.jmedchem.3c00149","article-title":"2-Aminobenzoxazole derivatives as potent inhibitors of the Sphingosine-1-phosphate transporter spinster homolog 2 (Spns2)","volume":"66","author":"Burgio","year":"2023","journal-title":"J Med Chem"},{"issue":"13","key":"10.1016\/j.bmcl.2026.130787_bb0135","doi-asserted-by":"crossref","first-page":"11273","DOI":"10.1021\/acs.jmedchem.4c00879","article-title":"Discovery of potent, orally bioavailable Sphingosine-1-phosphate transporter (Spns2) inhibitors","volume":"67","author":"Foster","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2026.130787_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129516","article-title":"Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors","volume":"96","author":"Shrader","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2026.130787_bb0145","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ejmech.2014.11.064","article-title":"Benzoxazoles and oxazolopyridines in medicinal chemistry studies","volume":"97","author":"Demmer","year":"2015","journal-title":"Eur J Med Chem"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130787_bb0150","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1039\/D5MD00336A","article-title":"Indazole \u2013 an emerging privileged scaffold: synthesis and its biological significance","volume":"16","author":"Singampalli","year":"2025","journal-title":"RSC Med Chem"},{"issue":"11","key":"10.1016\/j.bmcl.2026.130787_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23112783","article-title":"Recent advances in indazole-containing derivatives: synthesis and biological perspectives","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bmcl.2026.130787_bb0160","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.slasd.2023.07.001","article-title":"Assay of sphingosine 1-phosphate transporter spinster homolog 2 (Spns2) inhibitors","volume":"28","author":"Kharel","year":"2023","journal-title":"SLAS Discov"},{"issue":"2","key":"10.1016\/j.bmcl.2026.130787_bb0165","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41422-023-00913-0","article-title":"Structural basis of sphingosine-1-phosphate transport via human SPNS2","volume":"34","author":"Duan","year":"2023","journal-title":"Cell Res"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X26002544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:35:36Z","timestamp":1792067736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X26002544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":33,"alternative-id":["S0960894X26002544"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130787","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2026.130787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130787"}}