{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:40:35Z","timestamp":1784893235655,"version":"3.55.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006364","name":"INCa","doi-asserted-by":"publisher","award":["PLBIO22 PIC-ASO (INCA_16734"],"award-info":[{"award-number":["PLBIO22 PIC-ASO (INCA_16734"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INBS-04"],"award-info":[{"award-number":["ANR-10-INBS-04"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["23-CE15-0016-01"],"award-info":[{"award-number":["23-CE15-0016-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018874","name":"Laboratoire d&apos;Excellence EpiGenMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["18\/CRT\/6214"],"award-info":[{"award-number":["18\/CRT\/6214"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"ARC Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["18004"],"award-info":[{"award-number":["18004"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Neoplasia"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bneo.2025.100072","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T12:48:15Z","timestamp":1737377295000},"page":"100072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma"],"prefix":"10.1016","volume":"2","author":[{"given":"Laure","family":"Dutrieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-856X","authenticated-orcid":false,"given":"Sara","family":"Ovejero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miss Leriem","family":"Zellagui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"De Bruyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Muylaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Van Hemelrijck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yea-Lih","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-0929","authenticated-orcid":false,"given":"Elle","family":"Loughran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-9387","authenticated-orcid":false,"given":"Armelle","family":"Choquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4250-628X","authenticated-orcid":false,"given":"Talha","family":"Magat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Bouchouika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilhem","family":"Requirand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-9635","authenticated-orcid":false,"given":"Guillaume","family":"Cartron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-476X","authenticated-orcid":false,"given":"Charles","family":"Herbaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-4427","authenticated-orcid":false,"given":"Michel","family":"Cogn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-3973","authenticated-orcid":false,"given":"Eric","family":"Rivals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-8507","authenticated-orcid":false,"given":"Jean-Christophe","family":"Andrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-1339","authenticated-orcid":false,"given":"Alexandre","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pasero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-3207","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Moreaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.2020008346","article-title":"del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma","volume":"137","author":"Corre","year":"2021","journal-title":"Blood"},{"issue":"10272","key":"10.1016\/j.bneo.2025.100072_bib3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0140-6736(21)00135-5","article-title":"Multiple myeloma","volume":"397","author":"van de Donk","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41420-024-01818-6","article-title":"Targeted immunotherapy: harnessing the immune system to battle multiple myeloma","volume":"10","author":"Xu","year":"2024","journal-title":"Cell Death Discov"},{"issue":"5","key":"10.1016\/j.bneo.2025.100072_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1158\/2159-8290.CD-17-1461","article-title":"Mechanisms of oncogene-induced replication stress: jigsaw falling into place","volume":"8","author":"Kotsantis","year":"2018","journal-title":"Cancer Discov"},{"issue":"8","key":"10.1016\/j.bneo.2025.100072_bib6","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/leu.2011.94","article-title":"Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX","volume":"25","author":"Walters","year":"2011","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.trecan.2021.04.006","article-title":"Hypertranscription and replication stress in cancer","volume":"7","author":"Bowry","year":"2021","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13087","article-title":"Increased global transcription activity as a mechanism of replication stress in cancer","volume":"7","author":"Kotsantis","year":"2016","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.bneo.2025.100072_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41408-019-0221-9","article-title":"Mutational processes contributing to the development of multiple myeloma","volume":"9","author":"Hoang","year":"2019","journal-title":"Blood Cancer J"},{"issue":"21","key":"10.1016\/j.bneo.2025.100072_bib10","doi-asserted-by":"crossref","first-page":"11942","DOI":"10.1093\/nar\/gkaa944","article-title":"G-quadruplex\u2013R-loop interactions and the mechanism of anticancer G-quadruplex binders","volume":"48","author":"Miglietta","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.bneo.2025.100072_bib11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nrg3296","article-title":"DNA secondary structures: stability and function of G-quadruplex structures","volume":"13","author":"Bochman","year":"2012","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-021-01328-4","article-title":"G-quadruplexes: a promising target for cancer therapy","volume":"20","author":"Kosiol","year":"2021","journal-title":"Mol Cancer"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.molmed.2020.05.002","article-title":"G-quadruplex, friend or foe: the role of the G-quartet in anticancer strategies","volume":"26","author":"Carvalho","year":"2020","journal-title":"Trends Mol Med"},{"issue":"47","key":"10.1016\/j.bneo.2025.100072_bib14","doi-asserted-by":"crossref","first-page":"15758","DOI":"10.1021\/ja805615w","article-title":"A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres","volume":"130","author":"Rodriguez","year":"2008","journal-title":"J Am Chem Soc"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nchembio.780","article-title":"Small molecule-induced DNA damage identifies alternative DNA structures in human genes","volume":"8","author":"Rodriguez","year":"2012","journal-title":"Nat Chem Biol"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1073\/pnas.1810409116","article-title":"DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells","volume":"116","author":"De Magis","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bneo.2025.100072_bib17","first-page":"574","volume":"96","author":"Moreaux","year":"2011","journal-title":"A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines. 1"},{"issue":"12","key":"10.1016\/j.bneo.2025.100072_bib18","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1158\/1535-7163.MCT-12-0721","article-title":"Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors","volume":"11","author":"Moreaux","year":"2012","journal-title":"Mol Cancer Ther"},{"issue":"15","key":"10.1016\/j.bneo.2025.100072_bib19","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.3390\/cancers13153755","article-title":"Transcription\/replication conflicts in tumorigenesis and their potential role as novel therapeutic targets in multiple myeloma","volume":"13","author":"Dutrieux","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.bneo.2025.100072_bib20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3324\/haematol.2011.046821","article-title":"Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma","volume":"97","author":"Kassambara","year":"2012","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13148-018-0554-4","article-title":"PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs","volume":"10","author":"Herviou","year":"2018","journal-title":"Clin Epigenetics"},{"issue":"6","key":"10.1016\/j.bneo.2025.100072_bib22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/0008-5472.CAN-21-0218","article-title":"Targeting cellular iron homeostasis with ironomycin in diffuse large B-cell lymphoma","volume":"82","author":"Devin","year":"2022","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.105646","article-title":"The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA\/DNA hybrids (R-loops)","volume":"300","author":"de Amorim","year":"2024","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.celrep.2016.12.050","article-title":"Transcription dynamics prevent RNA-mediated genomic instability through SRPK2-dependent DDX23 phosphorylation","volume":"18","author":"Sridhara","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.bneo.2025.100072_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1271847","article-title":"Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma","volume":"13","author":"Bruyer","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.bneo.2025.100072_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-0716-0301-7_7","article-title":"Profiling cell type abundance and expression in bulk tissues with CIBERSORTx","volume":"2117","author":"Steen","year":"2020","journal-title":"Methods Mol Biol"},{"issue":"37","key":"10.1016\/j.bneo.2025.100072_bib27","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1038\/sj.onc.1210605","article-title":"Orchestration of chromatin-based processes: mind the TRRAP","volume":"26","author":"Murr","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ncb1343","article-title":"Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks","volume":"8","author":"Murr","year":"2006","journal-title":"Nat Cell Biol"},{"issue":"10","key":"10.1016\/j.bneo.2025.100072_bib29","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/jpm11100988","article-title":"RNA-sequencing-based transcriptomic score with prognostic and theranostic values in multiple myeloma","volume":"11","author":"Alaterre","year":"2021","journal-title":"J Pers Med"},{"issue":"5","key":"10.1016\/j.bneo.2025.100072_bib30","first-page":"529","article-title":"Gene abnormalities in multiple myeloma; the relevance of TP53, MDM2, and CDKN2A","volume":"88","author":"Elnenaei","year":"2003","journal-title":"Haematologica"},{"issue":"7201","key":"10.1016\/j.bneo.2025.100072_bib31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature07064","article-title":"IRF4 addiction in multiple myeloma","volume":"454","author":"Shaffer","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cytogfr.2013.12.002","article-title":"Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions","volume":"25","author":"Yi","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib33","first-page":"67","article-title":"Targeting TRAF3 downstream signaling pathways in B cell neoplasms","volume":"7","author":"Moore","year":"2015","journal-title":"J Cancer Sci Ther"},{"issue":"392","key":"10.1016\/j.bneo.2025.100072_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaa5157","article-title":"The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development","volume":"8","author":"Lin","year":"2015","journal-title":"Sci Signal"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13045-022-01336-x","article-title":"ASXL1\/2 mutations and myeloid malignancies","volume":"15","author":"Medina","year":"2022","journal-title":"J Hematol Oncol"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ccr.2012.06.032","article-title":"ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression","volume":"22","author":"Abdel-Wahab","year":"2012","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41408-022-00610-y","article-title":"Clonal and subclonal TP53 molecular impairment is associated with prognosis and progression in multiple myeloma","volume":"12","author":"Martello","year":"2022","journal-title":"Blood Cancer J"},{"issue":"19","key":"10.1016\/j.bneo.2025.100072_bib38","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1200\/JCO.18.00776","article-title":"Development and validation of a cytogenetic prognostic index predicting survival in multiple myeloma","volume":"37","author":"Perrot","year":"2019","journal-title":"J Clin Oncol"},{"issue":"33","key":"10.1016\/j.bneo.2025.100072_bib39","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1200\/JCO.2014.59.1503","article-title":"Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma","volume":"33","author":"Walker","year":"2015","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib40","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1038\/s41598-020-62885-0","article-title":"Concepts of double hit and triple hit disease in multiple myeloma, entity and prognostic significance","volume":"10","author":"Baysal","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.bneo.2025.100072_bib41","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.3324\/haematol.2021.278888","article-title":"Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma - a meta-analysis of 2,596 trial patients","volume":"106","author":"Weinhold","year":"2021","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cyto.b.21730","article-title":"BrdU incorporation in multiparameter flow cytometry: a new cell cycle assessment approach in multiple myeloma","volume":"96","author":"Requirand","year":"2019","journal-title":"Cytometry Part B Clinical"},{"issue":"26","key":"10.1016\/j.bneo.2025.100072_bib43","doi-asserted-by":"crossref","first-page":"11878","DOI":"10.1021\/jacs.2c04775","article-title":"Structural basis of pyridostatin and its derivatives specifically binding to G-quadruplexes","volume":"144","author":"Liu","year":"2022","journal-title":"J Am Chem Soc"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib44","doi-asserted-by":"crossref","first-page":"540","DOI":"10.7150\/thno.28374","article-title":"Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance","volume":"9","author":"Vikova","year":"2019","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.bneo.2025.100072_bib45","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.7150\/thno.54453","article-title":"Comprehensive characterization of the epigenetic landscape in multiple myeloma","volume":"12","author":"Alaterre","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bneo.2025.100072_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2023.1211512","article-title":"Higher-order G-quadruplexes in promoters are untapped drug targets","volume":"11","author":"Monsen","year":"2023","journal-title":"Front Chem"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01847-6","article-title":"RNA G-quadruplex structures control ribosomal protein production","volume":"11","author":"Varshney","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib48","article-title":"Analysis of translation using polysome profiling","volume":"45","author":"Chass\u00e9","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","article-title":"Cell cycle control in cancer","volume":"23","author":"Matthews","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.bneo.2025.100072_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108166","article-title":"BRD4 prevents R-loop formation and transcription-replication conflicts by ensuring efficient transcription elongation","volume":"32","author":"Edwards","year":"2020","journal-title":"Cell Rep"},{"issue":"23","key":"10.1016\/j.bneo.2025.100072_bib51","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113104","article-title":"RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart","volume":"42","author":"Heuz\u00e9","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/j.bneo.2025.100072_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.983181","article-title":"The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance","volume":"13","author":"Ovejero","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib53","first-page":"131","article-title":"IMiD resistance in multiple myeloma: current understanding of the underpinning biology and clinical impact","volume":"142","author":"Bird","year":"2023","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bneo.2025.100072_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174884","article-title":"Utilizing BMP-2 muteins for treatment of multiple myeloma","volume":"12","author":"Seher","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib55","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/10428190290012182","article-title":"Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells","volume":"43","author":"Kawamura","year":"2002","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"10.1016\/j.bneo.2025.100072_bib56","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1158\/0008-5472.CAN-17-1900","article-title":"Germline lysine-specific demethylase 1 (LSD1\/KDM1A) mutations confer susceptibility to multiple myeloma","volume":"78","author":"Wei","year":"2018","journal-title":"Cancer Res"},{"issue":"15","key":"10.1016\/j.bneo.2025.100072_bib57","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1158\/0008-5472.CAN-07-1015","article-title":"Proteasome function is required for DNA damage response and Fanconi anemia pathway activation","volume":"67","author":"Jacquemont","year":"2007","journal-title":"Cancer Res"},{"issue":"24","key":"10.1016\/j.bneo.2025.100072_bib58","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1182\/blood-2011-06-363911","article-title":"Bortezomib-induced \u201cBRCAness\u201d sensitizes multiple myeloma cells to PARP inhibitors","volume":"118","author":"Neri","year":"2011","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.bneo.2025.100072_bib59","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.15252\/embj.201797208","article-title":"Human THO\u2013Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability","volume":"36","author":"Salas-Armenteros","year":"2017","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib60","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/bjh.14525","article-title":"RNA polymerase I inhibition with CX-5461 as a novel therapeutic strategy to target MYC in multiple myeloma","volume":"177","author":"Lee","year":"2017","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib61","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-020-17503-y","article-title":"BRD4 prevents the accumulation of R-loops and protects against transcription\u2013replication collision events and DNA damage","volume":"11","author":"Lam","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.bneo.2025.100072_bib62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/hon.3016","article-title":"Dissecting the impact of bromodomain inhibitors on the interferon regulatory factor 4-MYC oncogenic axis in multiple myeloma","volume":"40","author":"Agnarelli","year":"2022","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.bneo.2025.100072_bib63","doi-asserted-by":"crossref","first-page":"957023","DOI":"10.3389\/fgene.2022.957023","article-title":"Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components","volume":"13","author":"Fang","year":"2022","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2013.12.015","article-title":"Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy","volume":"25","author":"Lohr","year":"2014","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib65","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS\u2013STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bneo.2025.100072_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.702584","article-title":"The replication stress response on a narrow path between genomic instability and inflammation","volume":"9","author":"T\u00e9cher","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.bneo.2025.100072_bib67","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molcel.2022.12.023","article-title":"p53 engages the cGAS\/STING cytosolic DNA sensing pathway for tumor suppression","volume":"83","author":"Ghosh","year":"2023","journal-title":"Mol Cell"},{"issue":"12","key":"10.1016\/j.bneo.2025.100072_bib68","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1093\/nar\/gkad365","article-title":"A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression","volume":"51","author":"Deiana","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bneo.2025.100072_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129384","article-title":"A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461","volume":"91","author":"Jin","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"10.1016\/j.bneo.2025.100072_bib70","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1158\/2159-8290.CD-18-1455","article-title":"First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study","volume":"9","author":"Khot","year":"2019","journal-title":"Cancer Discov"},{"issue":"1","key":"10.1016\/j.bneo.2025.100072_bib71","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1038\/s41467-022-31199-2","article-title":"Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies","volume":"13","author":"Hilton","year":"2022","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib72","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.18632\/aging.101282","article-title":"The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons","volume":"9","author":"Moruno-Manchon","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bneo.2025.100072_bib73","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52283","article-title":"Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons","volume":"9","author":"Moruno-Manchon","year":"2020","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.bneo.2025.100072_bib74","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1093\/nar\/gkab500","article-title":"G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells","volume":"49","author":"Miglietta","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"10.1016\/j.bneo.2025.100072_bib75","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1021\/acs.jmedchem.2c01058","article-title":"Discovery of a novel G-quadruplex and histone deacetylase (HDAC) dual-targeting agent for the treatment of triple-negative breast cancer","volume":"65","author":"Jiang","year":"2022","journal-title":"J Med Chem"},{"issue":"7","key":"10.1016\/j.bneo.2025.100072_bib76","doi-asserted-by":"crossref","DOI":"10.4161\/21624011.2014.941742","article-title":"Lenalidomide induces degradation of IKZF1 and IKZF3","volume":"3","author":"Kr\u00f6nke","year":"2014","journal-title":"OncoImmunology"},{"issue":"9","key":"10.1016\/j.bneo.2025.100072_bib77","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/s41416-021-01321-0","article-title":"Achieving clinical success with BET inhibitors as anti-cancer agents","volume":"124","author":"Shorstova","year":"2021","journal-title":"Br J Cancer"}],"container-title":["Blood Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032802500007X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032802500007X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:36:59Z","timestamp":1778938619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S295032802500007X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S295032802500007X"],"URL":"https:\/\/doi.org\/10.1016\/j.bneo.2025.100072","relation":{},"ISSN":["2950-3280"],"issn-type":[{"value":"2950-3280","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma","name":"articletitle","label":"Article Title"},{"value":"Blood Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bneo.2025.100072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100072"}}