{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T01:45:54Z","timestamp":1764121554492,"version":"3.46.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Neoplasia"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bneo.2025.100162","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:06:44Z","timestamp":1756116404000},"page":"100162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of the International Working Group MDS molecular taxonomy classes to a single institution cohort"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4964-6449","authenticated-orcid":false,"given":"Rohiverth","family":"Guarecuco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-416X","authenticated-orcid":false,"given":"Lisa","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J.","family":"Aubrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-0697","authenticated-orcid":false,"given":"Robert P.","family":"Hasserjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bneo.2025.100162_bib1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphological, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bneo.2025.100162_bib2","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00428-022-03465-7","article-title":"Advances in myelodysplastic\/myeloproliferative neoplasms","volume":"482","author":"Prakash","year":"2023","journal-title":"Virchows Arch"},{"issue":"20","key":"10.1016\/j.bneo.2025.100162_bib4","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1182\/blood.2020005488","article-title":"Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes","volume":"136","author":"Nagata","year":"2020","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bneo.2025.100162_bib5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1200\/JCO.20.01659","article-title":"Classification and personalized prognostic assessment on the basis of clinical and genomic features in myelodysplastic syndromes","volume":"39","author":"Bersanelli","year":"2021","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib6","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41375-023-01855-7","article-title":"MDS subclassification-do we still have to count blasts?","volume":"37","author":"Huber","year":"2023","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib7","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1038\/s41467-023-38515-4","article-title":"Molecular patterns identify distinct subclasses of myeloid neoplasia","volume":"14","author":"Kewan","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00277-014-2252-4","article-title":"Interobserver variance in myelodysplastic syndromes with less than 5 % bone marrow blasts: unilineage vs. multilineage dysplasia and reproducibility of the threshold of 2 % blasts","volume":"94","author":"Font","year":"2015","journal-title":"Ann Hematol"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00277-012-1565-4","article-title":"Inter-observer variance with the diagnosis of myelodysplastic syndromes (MDS) following the 2008 WHO classification","volume":"92","author":"Font","year":"2013","journal-title":"Ann Hematol"},{"issue":"13","key":"10.1016\/j.bneo.2025.100162_bib10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1182\/blood.2023023717","article-title":"Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement","volume":"145","author":"Borate","year":"2025","journal-title":"Blood"},{"issue":"26","key":"10.1016\/j.bneo.2025.100162_bib11","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1182\/blood.2023020078","article-title":"Diagnosis and classification of myelodysplastic syndromes","volume":"142","author":"Hasserjian","year":"2023","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41375-024-02484-4","article-title":"Relevance of blast counts for genetic subclassification in MDS","volume":"39","author":"Huber","year":"2025","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.bneo.2025.100162_bib13","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised international prognostic scoring system for myelodysplastic syndromes","volume":"120","author":"Greenberg","year":"2012","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bneo.2025.100162_bib14","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200008","article-title":"Molecular international prognostic scoring system for myelodysplastic syndromes","volume":"1","author":"Bernard","year":"2022","journal-title":"NEJM Evid"},{"issue":"15","key":"10.1016\/j.bneo.2025.100162_bib15","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1182\/blood.2023023727","article-title":"Molecular taxonomy of myelodysplastic syndromes and its clinical implications","volume":"144","author":"Bernard","year":"2024","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jmoldx.2016.02.003","article-title":"Validation and implementation of a custom next-generation sequencing clinical assay for hematologic malignancies","volume":"18","author":"Kluk","year":"2016","journal-title":"J Mol Diagn"},{"issue":"12","key":"10.1016\/j.bneo.2025.100162_bib17","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/nm.3729","article-title":"Anchored multiplex PCR for targeted next-generation sequencing","volume":"20","author":"Zheng","year":"2014","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib18","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41375-021-01486-w","article-title":"Marrow ring sideroblasts are highly predictive for TP53 mutation in MDS with excess blasts","volume":"36","author":"Swoboda","year":"2022","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.bneo.2025.100162_bib19","doi-asserted-by":"crossref","first-page":"E420","DOI":"10.1002\/ajh.26325","article-title":"Myelodysplastic syndromes with no somatic mutations detected by next-generation sequencing display similar features to myelodysplastic syndromes with detectable mutations","volume":"96","author":"Wang","year":"2021","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41408-024-01031-9","article-title":"Comparison of the 2022 world health organization classification and international consensus classification in myelodysplastic syndromes\/neoplasms","volume":"14","author":"Lee","year":"2024","journal-title":"Blood Cancer J"},{"issue":"3","key":"10.1016\/j.bneo.2025.100162_bib21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/bjh.19217","article-title":"Characteristics and long-term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic","volume":"204","author":"Casta\u00f1o-D\u00edez","year":"2024","journal-title":"Br J Haematol"},{"issue":"10","key":"10.1016\/j.bneo.2025.100162_bib22","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3324\/haematol.2019.222059","article-title":"Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions","volume":"104","author":"Valent","year":"2019","journal-title":"Haematologica"},{"issue":"14","key":"10.1016\/j.bneo.2025.100162_bib23","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1182\/blood-2010-10-311019","article-title":"Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A","volume":"118","author":"Jankowska","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bneo.2025.100162_bib24","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1182\/blood.2023021199","article-title":"Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022","volume":"143","author":"Baumgartner","year":"2024","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bneo.2025.100162_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1182\/bloodadvances.2018024216","article-title":"Invariant phenotype and molecular association of biallelic TET2 mutant myeloid neoplasia","volume":"3","author":"Awada","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.bneo.2025.100162_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.813149","article-title":"Lessons from pediatric MDS: approaches to germline predisposition to hematologic malignancies","volume":"12","author":"Avagyan","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib27","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/s41467-017-01590-5","article-title":"The genomic landscape of pediatric myelodysplastic syndromes","volume":"8","author":"Schwartz","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.bneo.2025.100162_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1470-2045(08)70339-5","article-title":"A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study","volume":"10","author":"Den Boer","year":"2009","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.bneo.2025.100162_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia","volume":"360","author":"Mullighan","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bneo.2025.100162_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11790","article-title":"Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia","volume":"7","author":"Lilljebj\u00f6rn","year":"2016","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.bneo.2025.100162_bib31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/gcc.22464","article-title":"ETV6\/RUNX1-like acute lymphoblastic leukemia: a novel B-cell precursor leukemia subtype associated with the CD27\/CD44 immunophenotype","volume":"56","author":"Zaliova","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"issue":"10399","key":"10.1016\/j.bneo.2025.100162_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0140-6736(23)00874-7","article-title":"Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial","volume":"402","author":"Platzbecker","year":"2023","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.bneo.2025.100162_bib33","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1158\/1078-0432.CCR-21-3467","article-title":"Impact of Venetoclax and Azacitidine in Treatment-Na\u00efve Patients with Acute Myeloid Leukemia and IDH1\/2 Mutations","volume":"28","author":"Pollyea","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"7","key":"10.1016\/j.bneo.2025.100162_bib34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s41375-018-0351-2","article-title":"TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups","volume":"33","author":"Haase","year":"2019","journal-title":"Leukemia"},{"issue":"16","key":"10.1016\/j.bneo.2025.100162_bib35","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1182\/blood.2024023840","article-title":"Influence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion","volume":"144","author":"Montoro","year":"2024","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib36","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1002\/ajh.26845","article-title":"TP53 mutations and variant allele frequency in myelodysplastic syndromes with del(5q): A Mayo-Moffitt study of 156 informative cases","volume":"98","author":"Fleti","year":"2023","journal-title":"Am J Hematol"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib37","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.3324\/haematol.2017.181404","article-title":"Emergence and evolution of TP53 mutations are key features of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide","volume":"103","author":"Lod\u00e9","year":"2018","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.bneo.2025.100162_bib38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3324\/haematol.2016.152025","article-title":"Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations","volume":"102","author":"Scharenberg","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.bneo.2025.100162_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2025.107736","article-title":"Molecular taxonomy of MDS\/CMML patients influences responses to hypomethylating agents and clinical outcomes","volume":"156","author":"Molina","year":"2025","journal-title":"Leuk Res"},{"issue":"1","key":"10.1016\/j.bneo.2025.100162_bib40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/leu.2014.262","article-title":"The importance of central pathology review in international trials: a comparison of local versus central bone marrow reticulin grading","volume":"29","author":"Pozdnyakova","year":"2015","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.bneo.2025.100162_bib41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/ijlh.13212","article-title":"Concordance among hematopathologists in classifying blasts plus promonocytes: A bone marrow pathology group study","volume":"42","author":"Foucar","year":"2020","journal-title":"Int J Lab Hematol"}],"container-title":["Blood Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328025000974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328025000974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T01:41:42Z","timestamp":1764121302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950328025000974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2950328025000974"],"URL":"https:\/\/doi.org\/10.1016\/j.bneo.2025.100162","relation":{},"ISSN":["2950-3280"],"issn-type":[{"type":"print","value":"2950-3280"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of the International Working Group MDS molecular taxonomy classes to a single institution cohort","name":"articletitle","label":"Article Title"},{"value":"Blood Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bneo.2025.100162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100162"}}