{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:11:12Z","timestamp":1779297072159,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000650","name":"Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004636","name":"Myeloma UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1298\/A8362"],"award-info":[{"award-number":["C1298\/A8362"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011723","name":"Myeloma UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"CRUK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Neoplasia"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bneo.2026.100191","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:34:16Z","timestamp":1768433656000},"page":"100191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteome-wide Mendelian randomization identifies protein associations and therapeutic targets for B-cell malignancy"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-975X","authenticated-orcid":false,"given":"Molly","family":"Went","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-7549","authenticated-orcid":false,"given":"Charlie","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-0164","authenticated-orcid":false,"given":"Amit","family":"Sud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0609-2644","authenticated-orcid":false,"given":"Sina A.","family":"Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-4611","authenticated-orcid":false,"given":"Philip J.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-6446","authenticated-orcid":false,"given":"Codie","family":"Gerlach-Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-4804","authenticated-orcid":false,"given":"Martin F.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Houlston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bneo.2026.100191_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017"},{"issue":"4","key":"10.1016\/j.bneo.2026.100191_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"K\u00fcppers","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"10.1016\/j.bneo.2026.100191_bib3","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nri953","article-title":"Lymphoid malignancies: the dark side of B-cell differentiation","volume":"2","author":"Shaffer","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.bneo.2026.100191_bib4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41375-023-01852-w","article-title":"Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment","volume":"37","author":"Hemminki","year":"2023","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.bneo.2026.100191_bib5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.bneo.2026.100191_bib6","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/s41591-024-03142-z","article-title":"Proteomic signatures improve risk prediction for common and rare diseases","volume":"30","author":"Carrasco-Zanini","year":"2024","journal-title":"Nat Med"},{"issue":"10290","key":"10.1016\/j.bneo.2026.100191_bib7","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/S0140-6736(21)00731-5","article-title":"Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","volume":"397","author":"Menon","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib8","first-page":"105","article-title":"The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal","volume":"3","author":"Ballehaninna","year":"2012","journal-title":"J Gastrointest Oncol"},{"issue":"7982","key":"10.1016\/j.bneo.2026.100191_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41576-020-0268-2","article-title":"Genetics meets proteomics: perspectives for large population-based studies","volume":"22","author":"Suhre","year":"2021","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib11","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/s41467-024-46927-z","article-title":"Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers","volume":"15","author":"Went","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.bneo.2026.100191_bib12","series-title":"Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation","year":"2015"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gepi.22506","article-title":"Statistical methods for cis-Mendelian randomization with two-sample summary-level data","volume":"47","author":"Gkatzionis","year":"2023","journal-title":"Genet Epidemiol"},{"issue":"suppl 1","key":"10.1016\/j.bneo.2026.100191_bib14","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J Anaesth"},{"issue":"8","key":"10.1016\/j.bneo.2026.100191_bib15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/ng.2652","article-title":"Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia","volume":"45","author":"Berndt","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.bneo.2026.100191_bib16","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1038\/ncomms6751","article-title":"A genome-wide association study of marginal zone lymphoma shows association to the HLA region","volume":"6","author":"Vijai","year":"2015","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.bneo.2026.100191_bib17","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/ng.3105","article-title":"Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma","volume":"46","author":"Cerhan","year":"2014","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.bneo.2026.100191_bib18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ajhg.2014.09.004","article-title":"Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region","volume":"95","author":"Skibola","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib19","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41467-017-00320-1","article-title":"Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility","volume":"8","author":"Sud","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib20","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1038\/s41467-024-50932-7","article-title":"Deciphering the genetics and mechanisms of predisposition to multiple myeloma","volume":"15","author":"Went","year":"2024","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.bneo.2026.100191_bib21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"CRP CHD genetics collaboration. Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001383","article-title":"Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts","volume":"10","author":"Vimaleswaran","year":"2013","journal-title":"PLoS Med"},{"issue":"5","key":"10.1016\/j.bneo.2026.100191_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.bneo.2026.100191_bib24","series-title":"Tabula Sapiens Single-Cell Dataset","author":"Pisco","year":"2021"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13059-020-1950-6","article-title":"Decontamination of ambient RNA in single-cell RNA-seq with DecontX","volume":"21","author":"Yang","year":"2020","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib29","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1038\/s41467-022-33944-z","article-title":"Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis","volume":"13","author":"Boiarsky","year":"2022","journal-title":"Nat Commun"},{"issue":"D1","key":"10.1016\/j.bneo.2026.100191_bib30","doi-asserted-by":"crossref","first-page":"D1467","DOI":"10.1093\/nar\/gkae1128","article-title":"Open targets platform: facilitating therapeutic hypotheses building in drug discovery","volume":"53","author":"Buniello","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.149.2.655","article-title":"Soluble forms of CD40 inhibit biologic responses of human B cells","volume":"149","author":"Fanslow","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.bneo.2026.100191_bib32","doi-asserted-by":"crossref","first-page":"107709","DOI":"10.1016\/j.pharmthera.2020.107709","article-title":"Molecular basis and therapeutic implications of CD40\/CD40L immune checkpoint","volume":"219","author":"Tang","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"7982","key":"10.1016\/j.bneo.2026.100191_bib33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.bneo.2026.100191_bib34","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1182\/blood-2016-01-691162","article-title":"APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment","volume":"127","author":"Tai","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bneo.2026.100191_bib35","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1182\/blood-2003-06-1984","article-title":"BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone","volume":"103","author":"Moreaux","year":"2004","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bneo.2026.100191_bib36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"3-4","key":"10.1016\/j.bneo.2026.100191_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cytogfr.2008.04.006","article-title":"TACI, an enigmatic BAFF\/APRIL receptor, with new unappreciated biochemical and biological properties","volume":"19","author":"Mackay","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4049\/jimmunol.1402070","article-title":"The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity","volume":"194","author":"Hoffmann","year":"2015","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib39","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood-2003-06-2043","article-title":"Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival","volume":"103","author":"Novak","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41467-021-27853-w","article-title":"A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers","volume":"13","author":"Wong","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.bneo.2026.100191_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2024.2314322","article-title":"CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells","volume":"25","author":"Wang","year":"2024","journal-title":"Cancer Biol Ther"},{"issue":"33","key":"10.1016\/j.bneo.2026.100191_bib42","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1200\/JCO.2014.59.1503","article-title":"Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma","volume":"33","author":"Walker","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bneo.2026.100191_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.628332","article-title":"The TRAIL in the treatment of human cancer: an update on clinical trials","volume":"8","author":"Snajdauf","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"2","key":"10.1016\/j.bneo.2026.100191_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41418-022-01059-z","article-title":"Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries","volume":"30","author":"Montinaro","year":"2023","journal-title":"Cell Death Differ"},{"issue":"11","key":"10.1016\/j.bneo.2026.100191_bib45","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00251-012-0619-z","article-title":"The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response","volume":"64","author":"Afrache","year":"2012","journal-title":"Immunogenetics"},{"issue":"4","key":"10.1016\/j.bneo.2026.100191_bib46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41423-024-01135-z","article-title":"Unsynchronized butyrophilin molecules dictate cancer cell evasion of V\u03b39V\u03b42 T-cell killing","volume":"21","author":"Wu","year":"2024","journal-title":"Cell Mol Immunol"}],"container-title":["Blood Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:26:15Z","timestamp":1779294375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950328026000026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2950328026000026"],"URL":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100191","relation":{},"ISSN":["2950-3280"],"issn-type":[{"value":"2950-3280","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteome-wide Mendelian randomization identifies protein associations and therapeutic targets for B-cell malignancy","name":"articletitle","label":"Article Title"},{"value":"Blood Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100191"}}