{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:13:14Z","timestamp":1789755194466,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004337","name":"F Hoffmann-La Roche Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Neoplasia"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bneo.2026.100264","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:32:03Z","timestamp":1783009923000},"page":"100264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low lymphoma macrophage infiltration predicts poor outcomes for R-CHOP\u2013 but not Pola-R-CHP\u2013treated patients with DLBCL"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-9824","authenticated-orcid":false,"given":"Franck","family":"Morschhauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-7415","authenticated-orcid":false,"given":"Alex F.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3990","authenticated-orcid":false,"given":"Christopher R.","family":"Flowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-6073","authenticated-orcid":false,"given":"Marek","family":"Trn\u011bn\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-6710","authenticated-orcid":false,"given":"John M.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Zhou","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-7708","authenticated-orcid":false,"given":"Philipp B.","family":"Staber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-2559","authenticated-orcid":false,"given":"Eliza A.","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-8057","authenticated-orcid":false,"given":"Koji","family":"Izutsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-2128","authenticated-orcid":false,"given":"Steven","family":"Le Gouill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Belada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-7463","authenticated-orcid":false,"given":"Alessandra","family":"Tucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-1274","authenticated-orcid":false,"given":"Will","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Bolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7373-362X","authenticated-orcid":false,"given":"Jamie","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Jardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-0307","authenticated-orcid":false,"given":"Katerina","family":"Hatzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/asheducation-2017.1.610","article-title":"Role of the microenvironment across histological subtypes of NHL","volume":"2017","author":"Tarte","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"8","key":"10.1016\/j.bneo.2026.100264_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrc3774","article-title":"The tumour microenvironment in B cell lymphomas","volume":"14","author":"Scott","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"10.1016\/j.bneo.2026.100264_bib3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1182\/blood.2023021002","article-title":"Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma","volume":"143","author":"Cerchietti","year":"2024","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bneo.2026.100264_bib4","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.bneo.2026.100264_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/j.seminhematol.2010.01.011","article-title":"Rituximab: mechanism of action","volume":"47","author":"Weiner","year":"2010","journal-title":"Semin Hematol"},{"issue":"6","key":"10.1016\/j.bneo.2026.100264_bib6","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1158\/2159-8290.CD-20-0839","article-title":"Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures","volume":"11","author":"Kotlov","year":"2021","journal-title":"Cancer Discov"},{"issue":"10","key":"10.1016\/j.bneo.2026.100264_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2021.08.011","article-title":"The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma","volume":"39","author":"Steen","year":"2021","journal-title":"Cancer Cell"},{"issue":"22","key":"10.1016\/j.bneo.2026.100264_bib8","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.bneo.2026.100264_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.06.002","article-title":"Large B cell lymphoma microenvironment archetype profiles","volume":"43","author":"Li","year":"2025","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-020-00900-7","article-title":"A randomized, open-label, phase III study of obinutuzumab or rituximab plus CHOP in patients with previously untreated diffuse large B-Cell lymphoma: final analysis of GOYA","volume":"13","author":"Sehn","year":"2020","journal-title":"J Hematol Oncol"},{"issue":"8","key":"10.1016\/j.bneo.2026.100264_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3324\/haematol.2013.100818","article-title":"R-CHOP with or without bevacizumab in patients with previously untreated diffuse large B-cell lymphoma: final MAIN study outcomes","volume":"99","author":"Seymour","year":"2014","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.bneo.2026.100264_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma","volume":"386","author":"Tilly","year":"2022","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.bneo.2026.100264_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3324\/haematol.2015.124008","article-title":"Tumor-associated macrophages in diffuse large B-cell lymphoma","volume":"100","author":"Kridel","year":"2015","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib14","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1186\/s12885-019-6208-x","article-title":"Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count","volume":"19","author":"Li","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bneo.2026.100264_bib15","article-title":"The prognostic value of tumor-associated macrophages detected by immunostaining in diffuse large B cell lymphoma: a meta-analysis","volume":"12","author":"Lin","year":"2022","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100264_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3324\/haematol.2014.113472","article-title":"Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial","volume":"100","author":"Riihijarvi","year":"2015","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-019-0638-6","article-title":"Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data","volume":"11","author":"Finotello","year":"2019","journal-title":"Genome Med"},{"key":"10.1016\/j.bneo.2026.100264_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-1-0716-0327-7_16","article-title":"Immunedeconv: an R package for unified access to computational methods for estimating immune cell fractions from bulk RNA-sequencing data","volume":"2120","author":"Sturm","year":"2020","journal-title":"Methods Mol Biol"},{"issue":"5","key":"10.1016\/j.bneo.2026.100264_bib20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1080\/10428194.2024.2446613","article-title":"gneSeqCOO: a novel method for classifying diffuse large B-cell lymphoma cell of origin based on bulk tumor RNA sequencing profiles","volume":"66","author":"Harris","year":"2025","journal-title":"Leuk Lymphoma"},{"issue":"15","key":"10.1016\/j.bneo.2026.100264_bib21","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1182\/bloodadvances.2021004770","article-title":"Prognostic significance of FCGR2B expression for the response of DLBCL patients to rituximab or obinutuzumab treatment","volume":"5","author":"Nowicka","year":"2021","journal-title":"Blood Adv"},{"issue":"20","key":"10.1016\/j.bneo.2026.100264_bib22","first-page":"2493","article-title":"Molecular determinants of clinical outcomes in a real-world diffuse large B-cell lymphoma population","volume":"141","author":"Alduaij","year":"2023","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.bneo.2026.100264_bib23","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1182\/bloodadvances.2023010402","article-title":"Distribution and clinical impact of molecular subtypes with Dark Zone signature of DLBCL in a Japanese real-world study","volume":"7","author":"Urata","year":"2023","journal-title":"Blood Adv"},{"issue":"4","key":"10.1016\/j.bneo.2026.100264_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.03.015","article-title":"A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications","volume":"37","author":"Wright","year":"2020","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib25","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/s41467-024-46220-z","article-title":"Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma","volume":"15","author":"Liu","year":"2024","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.bneo.2026.100264_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"9","key":"10.1016\/j.bneo.2026.100264_bib27","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1158\/2159-8290.CD-23-0802","article-title":"Molecular determinants of sensitivity to polatuzumab vedotin in diffuse large B cell lymphoma","volume":"14","author":"Corcoran","year":"2024","journal-title":"Cancer Discov"},{"issue":"4","key":"10.1016\/j.bneo.2026.100264_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1182\/bloodadvances.2018020602","article-title":"PD-L1 and tumor-associated macrophages in de novo DLBCL","volume":"3","author":"McCord","year":"2019","journal-title":"Blood Adv"},{"issue":"12","key":"10.1016\/j.bneo.2026.100264_bib29","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.bneo.2026.100264_bib30","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ccell.2024.04.002","article-title":"A temporal perspective for tumor-associated macrophage identities and functions","volume":"42","author":"Bleriot","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bneo.2026.100264_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ni.3324","article-title":"New insights into the multidimensional concept of macrophage ontogeny, activation and function","volume":"17","author":"Ginhoux","year":"2016","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.bneo.2026.100264_bib32","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s12032-011-0123-6","article-title":"High expression of tumor-infiltrating macrophages correlates with poor prognosis in patients with diffuse large B-cell lymphoma","volume":"29","author":"Cai","year":"2012","journal-title":"Med Oncol"},{"issue":"8","key":"10.1016\/j.bneo.2026.100264_bib33","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1056\/NEJMc2306105","article-title":"Cell-of-origin subtypes and therapeutic benefit from polatuzumab vedotin","volume":"389","author":"Palmer","year":"2023","journal-title":"N Engl J Med"}],"container-title":["Blood Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:54:31Z","timestamp":1789754071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950328026000750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2950328026000750"],"URL":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100264","relation":{},"ISSN":["2950-3280"],"issn-type":[{"value":"2950-3280","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low lymphoma macrophage infiltration predicts poor outcomes for R-CHOP\u2013 but not Pola-R-CHP\u2013treated patients with DLBCL","name":"articletitle","label":"Article Title"},{"value":"Blood Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100264"}}