{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:40:24Z","timestamp":1793356824513,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Neoplasia"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bneo.2026.100265","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:21:30Z","timestamp":1783095690000},"page":"100265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lineage switch in leukemia and lymphoma: case reports and molecular and cellular mechanisms"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5020-3656","authenticated-orcid":false,"given":"Jesse","family":"Adkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-0269","authenticated-orcid":false,"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/blood.2024026655","article-title":"Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia","volume":"146","author":"Silbert","year":"2025","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41408-024-00983-2","article-title":"Genetics and pathologic landscape of lineage switch of acute leukemia during therapy","volume":"14","author":"Zhou","year":"2024","journal-title":"Blood Cancer J"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1365-2141.2001.02841.x","article-title":"True histiocytic lymphoma following B-acute lymphoblastic leukaemia: case report with evidence for a common clonal origin in both neoplasms","volume":"113","author":"Bouabdallah","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bneo.2026.100265_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/406796","article-title":"Lineage switching in acute leukemias: a consequence of stem cell plasticity?","volume":"2012","author":"Dorantes-Acosta","year":"2012","journal-title":"Bone Marrow Res"},{"issue":"9","key":"10.1016\/j.bneo.2026.100265_bib6","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/pbc.26054","article-title":"A case of T-cell acute lymphoblastic leukemia relapsed as myeloid acute leukemia","volume":"63","author":"Paganin","year":"2016","journal-title":"Pediatr Blood Cancer"},{"issue":"7727","key":"10.1016\/j.bneo.2026.100265_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-018-0436-0","article-title":"The genetic basis and cell of origin of mixed phenotype acute leukaemia","volume":"562","author":"Alexander","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bneo.2026.100265_bib8","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1182\/blood-2007-11-124792","article-title":"Clonally related follicular lymphomas and histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone","volume":"111","author":"Feldman","year":"2008","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bneo.2026.100265_bib9","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/modpathol.2011.102","article-title":"Clonally related histiocytic\/dendritic cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a study of seven cases","volume":"24","author":"Shao","year":"2011","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2024.2329132","article-title":"Myeloid neoplasms post cytotoxic therapy: epidemiology, pathogenesis outcomes, prognostic factors, and treatment options","volume":"56","author":"Ma","year":"2024","journal-title":"Ann Med"},{"issue":"3","key":"10.1016\/j.bneo.2026.100265_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1182\/blood.V64.3.701.701","article-title":"Lineage switch in acute leukemia","volume":"64","author":"Stass","year":"1984","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib12","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1182\/blood.V74.6.2088.2088","article-title":"Molecular heterogeneity in acute leukemia lineage switch","volume":"74","author":"Gagnon","year":"1989","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bneo.2026.100265_bib13","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ajh.23266","article-title":"Lineage switch in childhood acute leukemia: an unusual event with poor outcome","volume":"87","author":"Rossi","year":"2012","journal-title":"Am J Hematol"},{"issue":"20","key":"10.1016\/j.bneo.2026.100265_bib14","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood-2015-08-665547","article-title":"Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy","volume":"127","author":"Gardner","year":"2016","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1470-2045(04)01428-7","article-title":"Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin","volume":"5","author":"Feldman","year":"2004","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/pbc.22810","article-title":"Pediatric histiocytic sarcoma clonally related to precursor B-cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4A","volume":"56","author":"Kumar","year":"2011","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.1016\/j.bneo.2026.100265_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28200","article-title":"Secondary histiocytic sarcoma with BRAFV600E mutation after T-cell acute lymphoblastic leukemia in a very young child with dramatic response to dabrafenib and trametinib","volume":"67","author":"Venkataraman","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ajcp\/aqx055","article-title":"Lineage switch between b-lymphoblastic leukemia and acute myeloid leukemia intermediated by \"occult\" myelodysplastic neoplasm: two cases of adult patients with evidence of genomic instability and clonal selection by chemotherapy","volume":"148","author":"Wu","year":"2017","journal-title":"Am J Clin Pathol"},{"issue":"9","key":"10.1016\/j.bneo.2026.100265_bib38","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3324\/haematol.2009.021212","article-title":"Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity","volume":"95","author":"Ratei","year":"2010","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.bneo.2026.100265_bib35","first-page":"1120","article-title":"Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia","volume":"74","author":"Brown","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib36","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/j.leukres.2009.08.020","article-title":"Clonal relationship between precursor B-cell acute lymphoblastic leukemia and histiocytic sarcoma: a case report and discussion in the context of similar cases","volume":"34","author":"McClure","year":"2010","journal-title":"Leuk Res"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s12185-009-0300-y","article-title":"Histiocytic\/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature","volume":"89","author":"Zhang","year":"2009","journal-title":"Int J Hematol"},{"issue":"5","key":"10.1016\/j.bneo.2026.100265_bib18","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/10428191003699845","article-title":"Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular\/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution","volume":"51","author":"Wang","year":"2010","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.bneo.2026.100265_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/PAS.0b013e3182098799","volume":"35","author":"Wang","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/labmed\/lmw011","article-title":"Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman","volume":"47","author":"Steussy","year":"2016","journal-title":"Lab Med"},{"issue":"3","key":"10.1016\/j.bneo.2026.100265_bib26","first-page":"729","article-title":"A rare B-myeloid conversion of follicular lymphoma into clonally related acute myeloid leukemia: a case report","volume":"13","author":"Yan","year":"2023","journal-title":"Life (Basel)"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib19","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1309\/AJCPWQ0I0DGXBMHO","article-title":"Transformation of chronic lymphocytic leukemia\/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone","volume":"132","author":"Fraser","year":"2009","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"10.1016\/j.bneo.2026.100265_bib20","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1200\/JCO.2011.38.8553","article-title":"Histiocytic sarcoma arising from clonally related mantle cell lymphoma","volume":"30","author":"Hure","year":"2012","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/ajcp\/aqac087","article-title":"Histiocytic sarcoma with CCND1 gene rearrangement clonally related and transdifferentiated from mantle cell lymphoma","volume":"158","author":"Kumar","year":"2022","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib22","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/bjh.17582","article-title":"Marginal zone lymphoma transdifferentiated to histiocytic sarcoma","volume":"194","author":"Sabatini","year":"2021","journal-title":"Br J Haematol"},{"issue":"8","key":"10.1016\/j.bneo.2026.100265_bib23","first-page":"737","article-title":"[Histiocytic sarcoma derived from the same origin as splenic marginal zone lymphoma revealed by exome analysis]","volume":"65","author":"Komata","year":"2024","journal-title":"Rinsho Ketsueki"},{"key":"10.1016\/j.bneo.2026.100265_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1609694","article-title":"Case report: histiocytic sarcoma as transdifferentiation of a marginal zone lymphoma-a case presentation based on postmortem examination and review of the literature","volume":"15","author":"Jauch","year":"2025","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib30","first-page":"78","article-title":"T-lymphoblastic lymphoma terminating as malignant histiocytosis with rearrangement of immunoglobulin heavy chain gene","volume":"5","author":"van der Kwast","year":"1991","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.bneo.2026.100265_bib27","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.3324\/haematol.2013.096750","article-title":"First description of the t(10;11)(q22;q23)\/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia","volume":"98","author":"Ittel","year":"2013","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cancergen.2016.05.070","article-title":"Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse","volume":"209","author":"Higuchi","year":"2016","journal-title":"Cancer Genet"},{"key":"10.1016\/j.bneo.2026.100265_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.21037\/sci.2019.05.02","article-title":"Lineage switch from T-cell lymphoblastic leukemia\/lymphoma to acute myeloid leukemia and back to T-cell lymphoblastic leukemia\/lymphoma in a patient diagnosed during pregnancy","volume":"6","author":"Aujla","year":"2019","journal-title":"Stem Cell Investig"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13000-018-0692-1","article-title":"Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing","volume":"13","author":"Gralewski","year":"2018","journal-title":"Diagn Pathol"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib32","first-page":"361","article-title":"Transdifferentiation of multiple myeloma into histiocytic sarcoma: case report of a highly unusual phenomenon","volume":"92","author":"Seth","year":"2025","journal-title":"Pathobiology"},{"issue":"10","key":"10.1016\/j.bneo.2026.100265_bib39","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.2024024006","article-title":"New frameworks for hematopoiesis derived from single-cell genomics","volume":"144","author":"Safina","year":"2024","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bneo.2026.100265_bib40","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1182\/blood-2004-07-2839","article-title":"Identification of a human B-cell\/myeloid common progenitor by the absence of CXCR4","volume":"105","author":"Hou","year":"2005","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib79","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/bloodadvances.2016003194","article-title":"Quantification and three-dimensional microanatomical organization of the bone marrow","volume":"1","author":"Nombela-Arrieta","year":"2017","journal-title":"Blood Adv"},{"issue":"25","key":"10.1016\/j.bneo.2026.100265_bib80","doi-asserted-by":"crossref","first-page":"14541","DOI":"10.1073\/pnas.261562798","article-title":"Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells","volume":"98","author":"Christensen","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.bneo.2026.100265_bib81","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1182\/blood-2004-06-2159","article-title":"Identification of Lin(-)Sca1(+)kit(+)CD34(+) Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients","volume":"105","author":"Yang","year":"2005","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.bneo.2026.100265_bib82","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1002\/j.1460-2075.1996.tb00949.x","article-title":"Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities","volume":"15","author":"McKercher","year":"1996","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib83","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.stem.2007.07.004","article-title":"Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages","volume":"1","author":"Arinobu","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib84","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2005.02.013","article-title":"Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment","volume":"121","author":"Adolfsson","year":"2005","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib85","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1074-7613(02)00366-7","article-title":"Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow","volume":"17","author":"Igarashi","year":"2002","journal-title":"Immunity"},{"issue":"7188","key":"10.1016\/j.bneo.2026.100265_bib86","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature06840","article-title":"The earliest thymic progenitors for T cells possess myeloid lineage potential","volume":"452","author":"Bell","year":"2008","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bneo.2026.100265_bib87","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1182\/blood-2010-09-309989","article-title":"Identification of Flt3+CD150- myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential","volume":"118","author":"Chi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bneo.2026.100265_bib88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-60761-421-0_13","article-title":"Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow","volume":"595","author":"Onai","year":"2010","journal-title":"Methods Mol Biol"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib41","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.stem.2011.11.012","article-title":"Historical origins of transdifferentiation and reprogramming","volume":"9","author":"Graf","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib42","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(87)90585-X","article-title":"Expression of a single transfected cDNA converts fibroblasts to myoblasts","volume":"51","author":"Davis","year":"1987","journal-title":"Cell"},{"issue":"7284","key":"10.1016\/j.bneo.2026.100265_bib43","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"Vierbuchen","year":"2010","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bneo.2026.100265_bib44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bneo.2026.100265_bib46","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1038\/nprot.2007.418","article-title":"Induction of pluripotent stem cells from fibroblast cultures","volume":"2","author":"Takahashi","year":"2007","journal-title":"Nat Protoc"},{"issue":"6753","key":"10.1016\/j.bneo.2026.100265_bib47","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the B-lymphoid lineage depends on the transcription factor Pax5","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib48","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.immuni.2007.05.010","article-title":"The transcriptional regulation of B cell lineage commitment","volume":"26","author":"Nutt","year":"2007","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.bneo.2026.100265_bib49","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.4049\/jimmunol.166.10.6091","article-title":"Role for transcription Pax5A factor in maintaining commitment to the B cell lineage by selective inhibition of granulocyte-macrophage colony-stimulating factor receptor expression","volume":"166","author":"Chiang","year":"2001","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib50","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1074-7613(02)00472-7","article-title":"Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1","volume":"17","author":"Souabni","year":"2002","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bneo.2026.100265_bib51","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1182\/blood-2002-06-1797","article-title":"Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing\/reactivation of the EBF\/Pax5 pathway","volume":"101","author":"Yu","year":"2003","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bneo.2026.100265_bib52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","article-title":"Stepwise reprogramming of B-cells into macrophages","volume":"117","author":"Xie","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib53","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.immuni.2004.11.006","article-title":"Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C\/EBP alpha","volume":"21","author":"Zhang","year":"2004","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib54","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.celrep.2013.03.003","article-title":"C\/EBP\u03b1 induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity","volume":"3","author":"Rapino","year":"2013","journal-title":"Cell Rep"},{"issue":"13","key":"10.1016\/j.bneo.2026.100265_bib55","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1073\/pnas.1413383112","article-title":"Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages","volume":"112","author":"McClellan","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.bneo.2026.100265_bib56","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.celrep.2017.02.029","article-title":"A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors","volume":"18","author":"Itoh-Nakadai","year":"2017","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/j.bneo.2026.100265_bib57","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0145-2126(92)90153-X","article-title":"Interleukin 6 induces myeloid differentiation of a human biphenotypic leukemic cell line","volume":"16","author":"Cohen","year":"1992","journal-title":"Leuk Res"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molcel.2012.08.007","article-title":"Tet2 facilitates the de-repression of myeloid target genes during C\/EBPa induced transdifferentiation of pre-B cells","volume":"48","author":"Kallin","year":"2012","journal-title":"Mol Cell"},{"issue":"23","key":"10.1016\/j.bneo.2026.100265_bib59","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1182\/blood.V126.23.1368.1368","article-title":"TET2 mutations are highly associated with RUNX1-RUNX1T1 translocations and NPMc+ in childhood AML: a report from Children's Oncology Group AAML03P1, AAML0531 and NCI\/COG target AML initiative","volume":"126","author":"Kutny","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bneo.2026.100265_bib60","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.stem.2018.11.001","article-title":"Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate","volume":"23","author":"Sardina","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"7487","key":"10.1016\/j.bneo.2026.100265_bib61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature12885","article-title":"C\/EBP\u03b1 poises B cells for rapid reprogramming into induced pluripotent stem cells","volume":"506","author":"Di Stefano","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib62","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41375-019-0643-1","article-title":"B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation","volume":"34","author":"Bueno-Costa","year":"2020","journal-title":"Leukemia"},{"issue":"17","key":"10.1016\/j.bneo.2026.100265_bib63","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood.2021015036","article-title":"Epigenetic regulator genes direct lineage switching in MLL\/AF4 leukemia","volume":"140","author":"Tirtakusuma","year":"2022","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib64","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1182\/blood.2019001438","article-title":"Coactivation of NF-\u03baB and notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion","volume":"135","author":"Xiu","year":"2020","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.bneo.2026.100265_bib65","doi-asserted-by":"crossref","first-page":"29804","DOI":"10.18632\/oncotarget.7772","article-title":"Notch signaling: its roles and therapeutic potential in hematological malignancies","volume":"7","author":"Gu","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/biomedicines5020027","article-title":"NF-\u03baB in hematological malignancies","volume":"5","author":"Imbert","year":"2017","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.bneo.2026.100265_bib67","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/nm.3247","article-title":"BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint","volume":"19","author":"Swaminathan","year":"2013","journal-title":"Nat Med"},{"issue":"24","key":"10.1016\/j.bneo.2026.100265_bib68","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1182\/bloodadvances.2020002726","article-title":"CLL dedifferentiation to clonally related myeloid cells","volume":"4","author":"Dong","year":"2020","journal-title":"Blood Adv"},{"issue":"suppl 1","key":"10.1016\/j.bneo.2026.100265_bib69","first-page":"64","article-title":"To B- or not to B-: a review of lineage switched acute leukemia","volume":"44","author":"Kurzer","year":"2022","journal-title":"IntJ Lab"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib70","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/s12887-025-05847-7","article-title":"Global, regional, and national burden of childhood leukemia from 1990 to 2021","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Pediatr"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib71","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41591-022-01720-7","article-title":"Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia","volume":"28","author":"Khabirova","year":"2022","journal-title":"Nat Med"},{"issue":"14","key":"10.1016\/j.bneo.2026.100265_bib72","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1182\/blood.2021013442","article-title":"Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia","volume":"139","author":"Chen","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.bneo.2026.100265_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1724473","article-title":"Flow cytometric detection of leukemic stem cells in acute myeloid leukemia: current status and future directions","volume":"16","author":"Youssef","year":"2025","journal-title":"Front Pharmacol"},{"issue":"7954","key":"10.1016\/j.bneo.2026.100265_bib74","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41586-023-05812-3","article-title":"The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia","volume":"615","author":"Issa","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bneo.2026.100265_bib75","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1182\/blood.2025029260","article-title":"Postimmunotherapy lineage switch: where to from here [commentary]?","volume":"146","author":"Kuzich","year":"2025","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bneo.2026.100265_bib76","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1182\/blood.2024024517","article-title":"How I treat postimmunotherapy relapsed B-ALL","volume":"145","author":"Lamble","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.bneo.2026.100265_bib77","author":"Faulk"},{"issue":"2","key":"10.1016\/j.bneo.2026.100265_bib78","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41379-020-00673-x","article-title":"The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy","volume":"34","author":"Egan","year":"2021","journal-title":"Mod Pathol"}],"updated-by":[{"DOI":"10.1016\/j.bneo.2026.100327","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000}}],"container-title":["Blood Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950328026000762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:38:59Z","timestamp":1787737139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950328026000762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2950328026000762"],"URL":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100265","relation":{},"ISSN":["2950-3280"],"issn-type":[{"value":"2950-3280","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lineage switch in leukemia and lymphoma: case reports and molecular and cellular mechanisms","name":"articletitle","label":"Article Title"},{"value":"Blood Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bneo.2026.100265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100265"}}