{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:28:16Z","timestamp":1791282496359,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.bone.2005.07.015","type":"journal-article","created":{"date-parts":[[2005,8,27]],"date-time":"2005-08-27T11:08:27Z","timestamp":1125140907000},"page":"154-166","source":"Crossref","is-referenced-by-count":125,"title":["Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions"],"prefix":"10.1016","volume":"38","author":[{"given":"Brian T.","family":"Feeley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Krenek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington K.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth C.","family":"Gamradt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Huard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2005.07.015_bib1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1359\/jbmr.2000.15.4.663","article-title":"Essential requirement of BMPs-2\/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin","volume":"15","author":"Abe","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1006\/cyto.1999.0508","article-title":"Identification of bone morphogenetic proteins and their receptors in human breast cancer cell lines: importance of BMP2","volume":"11","author":"Arnold","year":"1999","journal-title":"Cytokine"},{"key":"10.1016\/j.bone.2005.07.015_bib3","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1038\/sj.onc.1207386","article-title":"Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells","volume":"23","author":"Baade Ro","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2005.07.015_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jcb.10679","article-title":"Bone morphogenetic protein signaling in prostate cancer cell lines","volume":"91","author":"Brubaker","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.bone.2005.07.015_bib5","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.280.5368.1455","article-title":"Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton","volume":"280","author":"Brunet","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bone.2005.07.015_bib6","doi-asserted-by":"crossref","first-page":"L81","DOI":"10.1152\/ajplung.00160.2003","article-title":"BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells","volume":"286","author":"Buckley","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bone.2005.07.015_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1359\/jbmr.2001.16.2.338","article-title":"Eficacy of etanercept for wear debris-induced osteolysis","volume":"16","author":"Childs","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/pros.10091","article-title":"Establishment and characterization of osseous prostate cancer models: intra-tibial injection of human prostate cancer cells","volume":"52","author":"Corey","year":"2002","journal-title":"Prostate"},{"key":"10.1016\/j.bone.2005.07.015_bib9","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1093\/emboj\/17.16.4735","article-title":"BMP-4 is proteolytically activated by furin and\/or PC6 during vertebrate embryonic development","volume":"17","author":"Cui","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2005.07.015_bib10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1091\/mbc.11.3.1023","article-title":"Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine\/threonine kinase receptors","volume":"11","author":"Gilboa","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bone.2005.07.015_bib11","first-page":"329","article-title":"Mechanisms of metastasis: prostate cancer","volume":"239","author":"Glaves","year":"1987","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nature01245","article-title":"Structural basis of BMP signalling inhibition by the cysteine knot protein Noggin","volume":"420","author":"Groppe","year":"2002","journal-title":"Nature"},{"issue":"Suppl 3","key":"10.1016\/j.bone.2005.07.015_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2106\/00004623-200300003-00010","article-title":"Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cysteine knot protein","volume":"85-A","author":"Groppe","year":"2003","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2005.07.015_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2106\/00004623-200401000-00013","article-title":"Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model","volume":"86-A","author":"Hannallah","year":"2004","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2005.07.015_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/pros.2990240406","article-title":"Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells","volume":"24","author":"Harris","year":"1994","journal-title":"Prostate"},{"key":"10.1016\/j.bone.2005.07.015_bib16","first-page":"5022","article-title":"Growth regulation of human prostate cancer cells by bone morphogenetic protein-2","volume":"57","author":"Ide","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2005.07.015_bib17","first-page":"16","article-title":"Establishment and characterization of a human prostatic carcinoma cell line (PC-3)","volume":"17","author":"Kaighn","year":"1979","journal-title":"Invest. Urol."},{"key":"10.1016\/j.bone.2005.07.015_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S8756-3282(00)00358-6","article-title":"Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts","volume":"27","author":"Kaneko","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.bone.2005.07.015_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1359-6101(97)00036-1","article-title":"Signal transduction by bone morphogenetic proteins","volume":"9","author":"Kawabata","year":"1998","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bone.2005.07.015_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0016-5085(99)70024-7","article-title":"Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo","volume":"116","author":"Kleeff","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bone.2005.07.015_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/(SICI)1097-0045(19990601)39:4<246::AID-PROS5>3.0.CO;2-U","article-title":"Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment","volume":"39","author":"Koeneman","year":"1999","journal-title":"Prostate"},{"key":"10.1016\/j.bone.2005.07.015_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1172\/JCI113186","article-title":"Characteristics of prostate-derived growth factors for cells of the osteoblast phenotype","volume":"80","author":"Koutsilieris","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2005.07.015_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3322\/canjclin.48.1.6","article-title":"Cancer statistics CA","volume":"28","author":"Landis","year":"1998","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.bone.2005.07.015_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1006106209527","article-title":"Mechanisms, hypotheses and questions regarding prostate cancer micrometastases to bone","volume":"17","author":"Lange","year":"1998","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bone.2005.07.015_bib25","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/carcin\/bgg100","article-title":"The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells","author":"Langenfeld","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bone.2005.07.015_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0736-0266(02)00095-5","article-title":"Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone","volume":"21","author":"Lee","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib27","first-page":"5564","article-title":"Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse model","volume":"62","author":"Lee","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2005.07.015_bib28","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2106\/00004623-200206000-00022","article-title":"The role of growth factors in the repair of bone. Biology and clinical applications","volume":"84-A","author":"Lieberman","year":"2002","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2005.07.015_bib29","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/MCB.15.7.3479","article-title":"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs","volume":"15","author":"Liu","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2005.07.015_bib30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bone.2005.07.015_bib31","first-page":"249","article-title":"Subtle differences in the mitogenic effects of recombinant human bone morphogenetic proteins-2 to -7 on DNA synthesis on primary bone-forming cells and identification of BMP-2\/4 receptor","volume":"58","author":"Mayer","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2005.07.015_bib32","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gad.12.10.1438","article-title":"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite","volume":"12","author":"McMahon","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2005.07.015_bib33","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1074\/jbc.M102750200","article-title":"The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways","volume":"277","author":"Nohe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2005.07.015_bib34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/mthe.2001.0423","article-title":"Development of an MFG-based retroviral vector system for secretion of high levels of functionally active human BMP4","volume":"4","author":"Peng","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bone.2005.07.015_bib35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1172\/JCI15153","article-title":"Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4","volume":"110","author":"Peng","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2005.07.015_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0092-8674(94)90294-1","article-title":"Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor","volume":"78","author":"Penton","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bone.2005.07.015_bib37","first-page":"277","article-title":"Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells","volume":"63","author":"Pouliot","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2005.07.015_bib38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF01300186","article-title":"Radical prostatectomy as treatment for prostate-specific antigen-detected stage T1c prostate cancer","volume":"15","author":"Pound","year":"1997","journal-title":"World J. Urol."},{"key":"10.1016\/j.bone.2005.07.015_bib39","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1073\/pnas.92.17.7632","article-title":"Cloning and characterization of a human type II receptor for bone morphogenetic proteins","volume":"92","author":"Rosenzweig","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2005.07.015_bib40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","article-title":"Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration","volume":"65","author":"Rothhammer","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2005.07.015_bib41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jor.1100170217","article-title":"Bone morphogenetic proteins: an update on basic biology and clinical relevance","volume":"17","author":"Schmitt","year":"1999","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1101\/gad.11.4.451","article-title":"A role for bone morphogenetic proteins in the induction of cardiac myogenesis","volume":"11","author":"Schultheiss","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2005.07.015_bib43","first-page":"89","article-title":"Differential expression and regulation of bone morphogenetic protein 7 in breast cancer","volume":"23","author":"Schwalbe","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bone.2005.07.015_bib44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/jcp.55.5.381","article-title":"The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter","volume":"55","author":"Sulzbacher","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bone.2005.07.015_bib45","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1210\/en.140.5.2125","article-title":"Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro","volume":"140","author":"Suzawa","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2005.07.015_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3816\/CGC.2003.n.011","article-title":"Ten-year survival in patients with metastatic prostate cancer","volume":"2","author":"Tangen","year":"2003","journal-title":"Clin. Prostate Cancer"},{"key":"10.1016\/j.bone.2005.07.015_bib47","first-page":"33","article-title":"Signal transduction of bone morphogenetic proteins in osteoblast differentiation","volume":"85-A","author":"ten Dijke","year":"2003","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2005.07.015_bib48","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1016\/S0021-9258(17)32506-1","article-title":"Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4","volume":"269","author":"ten Dijke","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2005.07.015_bib49","first-page":"253","article-title":"Bone morphogenetic protein-2 induces hypophosphorylation of Rb protein and repression of E2F in androgen-treated LNCaP human prostate cancer cells","volume":"15","author":"Tomari","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bone.2005.07.015_bib50","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2004.02.016","article-title":"BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells","volume":"316","author":"Wen","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2005.07.015_bib51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000025634","article-title":"BMP-2 gene expression and effects on human vascular smooth muscle cells","volume":"36","author":"Willette","year":"1999","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.bone.2005.07.015_bib52","first-page":"241","article-title":"Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues","volume":"8","author":"Wordinger","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bone.2005.07.015_bib53","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/pros.10349","article-title":"Intraosseous growth of human prostate cancer in implanted adult human bone: relationship of prostate cancer cells to osteoclasts in osteoblastic metastatic lesions","volume":"58","author":"Yonou","year":"2004","journal-title":"Prostate"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328205002838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328205002838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T09:18:17Z","timestamp":1683191897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328205002838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S8756328205002838"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2005.07.015","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}