{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:52:07Z","timestamp":1768621927572,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.bone.2005.08.028","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T09:55:03Z","timestamp":1138355703000},"page":"23-27","source":"Crossref","is-referenced-by-count":10,"special_numbering":"S1","title":["Protelos: Nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis"],"prefix":"10.1016","volume":"38","author":[{"given":"S.","family":"Adami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2005.08.028_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jbmr.5650110203","article-title":"A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates","volume":"11","author":"Parfitt","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2005.08.028_bib2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJM199803123381107","article-title":"Treatment of postmenopausal osteoporosis","volume":"338","author":"Eastell","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2005.08.028_bib3","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2003-1703","article-title":"Early changes in biochemical markers of bone formation correlate with improvements in bone structure during Teriparatide therapy","volume":"90","author":"Dobnig","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2005.08.028_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jbmr.5650080512","article-title":"An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats","volume":"8","author":"Marie","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2005.08.028_bib5","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1210\/jc.87.5.2060","article-title":"Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis\u2014A 2-year randomised placebo-controlled trial","volume":"87","author":"Meunier","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2005.08.028_bib6","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1007\/s00198-002-1341-8","article-title":"Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis","volume":"14","author":"Meunier","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2005.08.028_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa022436","article-title":"The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis","volume":"350","author":"Meunier","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2005.08.028_bib8","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1210\/jc.2004-1774","article-title":"Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis treatment of peripheral osteoporosis (TROPOS) study","volume":"90","author":"Reginster","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2005.08.028_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1385\/JCD:2:1:37","article-title":"The use of different dual X-ray absorptiometry brands in a multicenter clinical trial","volume":"2","author":"Slosman","year":"1999","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bone.2005.08.028_bib10","unstructured":"Committee for Proprietary Medicinal Products. Note for guidance on post menopausal osteoporosis in women Rev. 1 (CPMP adopted January 2001)."},{"key":"10.1016\/j.bone.2005.08.028_bib11","unstructured":"FDA, Draft Guidance Postmenopausal Osteoporosis. Preclinical and clinical evaluation of agents used in the prevention and treatment of postmenopausal osteoporosis (Issued 4\/1994)."},{"key":"10.1016\/j.bone.2005.08.028_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJM200102013440503","article-title":"Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group","volume":"344","author":"McClung","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2005.08.028_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Randomized trial of the effects of risedronate on vertebral fractures in women with established post-menopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2005.08.028_bib14","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jama.282.14.1344","article-title":"Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis","volume":"282","author":"Harris","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2005.08.028_bib15","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of the effect of alendronate on risk of fracture in women with existing vertebral fractures, Fracture Intervention Trial Research Group","volume":"348","author":"Black","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2005.08.028_bib16","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1001\/jama.280.24.2077","article-title":"Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial","volume":"280","author":"Cummings","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2005.08.028_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/jech.44.3.241","article-title":"Incidence of fractures in a geographically defined population","volume":"44","author":"Donaldson","year":"1990","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.bone.2005.08.028_bib18","unstructured":"Coulombe J, Faure H, Robin B, Tsouderos Y, Ruat M. Activation of the rat and mouse cation-sensing receptor by strontium ranelate and its modulation by extracellular calcium. Osteoporos Int 13 (Suppl 1) P70MO."},{"key":"10.1016\/j.bone.2005.08.028_bib19","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1359\/jbmr.040114","article-title":"A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium","volume":"19","author":"Pi","year":"2004","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328205005314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328205005314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T15:55:23Z","timestamp":1547826923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328205005314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S8756328205005314"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2005.08.028","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}