{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:04:56Z","timestamp":1790373896091,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004338","name":"Saint Joseph University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bone.2006.01.140","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:49:44Z","timestamp":1140594584000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?"],"prefix":"10.1016","volume":"39","author":[{"given":"Asma","family":"Arabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafic","family":"Baddoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassane","family":"Awada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Salamoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazi","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"El-Hajj Fuleihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.01.140_bib1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/ajcn\/78.5.912","article-title":"Long-latency deficiency disease: insights from calcium and vitaminD","volume":"78","author":"Heaney","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2006.01.140_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00198-003-1566-1","article-title":"Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women","volume":"15","author":"Bhattoa","year":"2004","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s001980050141","article-title":"High prevalence of hypovitaminosis D among free-living postmenopausal women referred to an osteoporosis outpatient clinic in northern Italy for initial screening","volume":"9","author":"Bettica","year":"1999","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00198-003-1390-7","article-title":"Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors","volume":"14","author":"Isaia","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s001980050030","article-title":"Prevalence of vitamin D insufficiency in an adult normal population","volume":"7","author":"Chapuy","year":"1997","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.amjmed.2003.12.029","article-title":"Positive association between 25-hydroxyvitamin D levels and bone mineral density: a population-based study of younger and older adults","volume":"116","author":"Bischoff-Ferrari","year":"2004","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bone.2006.01.140_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF02672505","article-title":"Vitamin D and bone mineral density","volume":"8","author":"Collins","year":"1998","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s001980170153","article-title":"Vitamin D and bone mineral density in ambulatory women living in Buenos Aires, Argentina","volume":"12","author":"Fradinger","year":"2001","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ajcn\/36.5.1014","article-title":"Vitamin D and bone health in the elderly","volume":"36","author":"Parfitt","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2006.01.140_bib10","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1359\/jbmr.1997.12.12.2119","article-title":"Age-related (type II) femoral neck osteoporosis in men: biochemical evidence for both hypovitaminosis D- and androgen deficiency-induced bone resorption","volume":"12","author":"Boonen","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib11","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/jama.281.16.1505","article-title":"Occult vitamin D deficiency in postmenopausal US women with acute hip fracture","volume":"281","author":"LeBoff","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.01.140_bib12","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1046\/j.1532-5415.2003.51510.x","article-title":"Serum vitamin D and falls in older women in residential care in Australia","volume":"51","author":"Flicker","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bone.2006.01.140_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1532-5415.2004.52060.x","article-title":"Alfacalcidol reduces the number of fallers in a community-dwelling elderly population with a minimum calcium intake of more than 500 mg daily","volume":"52","author":"Dukas","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bone.2006.01.140_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s001980200023","article-title":"Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study","volume":"13","author":"Chapuy","year":"2002","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib15","first-page":"1052","article-title":"Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial","volume":"80","author":"Ooms","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.01.140_bib16","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1056\/NEJM199709043371003","article-title":"Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older","volume":"337","author":"Dawson-Hughes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.140_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1359\/jbmr.2003.18.2.343","article-title":"Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial","volume":"18","author":"Bischoff","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib18","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1001\/jama.291.16.1999","article-title":"Effect of Vitamin D on falls: a meta-analysis","volume":"291","author":"Bischoff-Ferrari","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.01.140_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1359\/jbmr.1997.12.1.144","article-title":"Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women?","volume":"12","author":"Chen","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jbmr.5650110618","article-title":"Relationship between body composition and bone mass in women","volume":"11","author":"Khosla","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib21","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1210\/jc.2003-030604","article-title":"Longitudinal Aging Study Amsterdam low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam","volume":"88","author":"Visser","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.01.140_bib22","unstructured":"Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal."},{"key":"10.1016\/j.bone.2006.01.140_bib23","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1359\/jbmr.2001.16.8.1408","article-title":"Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women","volume":"16","author":"Mezquita-Raya","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator variable distinction in social psychological research: conceptual strategic and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J. Pers. Soc. Psychol."},{"key":"10.1016\/j.bone.2006.01.140_bib25","first-page":"1004","article-title":"Universal standardization for dual energy X-ray absorptiometry: patient and phantom cross-calibration result","volume":"10","author":"Genant","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib26","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s001980070024","article-title":"The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women","volume":"11","author":"Sigurdsson","year":"2000","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s001980200012","article-title":"Vitamin D and muscle function","volume":"13","author":"Pfeifer","year":"2002","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.140_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0003-9993(99)90307-6","article-title":"Muscle strength in the elderly: Its relation to vitamin D metabolites","volume":"80","author":"Bischoff","year":"1999","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bone.2006.01.140_bib29","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bone.2004.04.003","article-title":"Vitamin D deficiency and secondary hyperparathyroidism and the association with bone mineral density in persons with Pakistani and Norwegian background living in Oslo, Norway, The Oslo Health Study","volume":"35","author":"Meyer","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.140_bib30","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1359\/jbmr.2001.16.11.2142","article-title":"determinants of bone mineral density in older men and women: body composition as mediator","volume":"16","author":"Pluijm","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.140_bib31","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/ajcn\/80.5.1428","article-title":"Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents","volume":"80","author":"Arabi","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2006.01.140_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bone.2004.03.005","article-title":"vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways","volume":"35","author":"Duque","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.140_bib33","doi-asserted-by":"crossref","first-page":"19301","DOI":"10.1074\/jbc.274.27.19301","article-title":"STAT3 activation in stromal\/osteoblastic cells is required for induction of the receptor activator of NF-kB ligand and stimulation of osteoclastogenesis by gp 130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone","volume":"274","author":"O'Brien","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 6","key":"10.1016\/j.bone.2006.01.140_bib34","doi-asserted-by":"crossref","first-page":"S1730","DOI":"10.1093\/ajcn\/80.6.1730S","article-title":"Genomic and proteomic approaches for probing the role of vitamin D on health","volume":"80","author":"Fleet","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2006.01.140_bib35","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJM199803193381201","article-title":"Hypovitaminosis D in medical inpatients","volume":"338","author":"Thomas","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.140_bib36","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jama.1995.03530210037027","article-title":"Vitamin D deficiency in homebound elderly persons","volume":"274","author":"Gloth","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.01.140_bib37","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/clinchem\/46.10.1657","article-title":"Comparison of commercially available I-based RIA methods for the determination of circulating 25-D. Hydroxyvitamin","volume":"46","author":"Hollis","year":"2000","journal-title":"Clin. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206001906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206001906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:36:27Z","timestamp":1762659387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328206001906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S8756328206001906"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.01.140","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2006.01.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}