{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:37:28Z","timestamp":1791020248397,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bone.2006.01.145","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T13:48:25Z","timestamp":1142344105000},"page":"260-267","source":"Crossref","is-referenced-by-count":57,"title":["Combined treatment with a \u03b2-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice"],"prefix":"10.1016","volume":"39","author":[{"given":"Dominique D.","family":"Pierroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Bouxsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge L.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.01.145_bib1","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1359\/jbmr.2001.16.9.1665","article-title":"Human parathyroid hormone 1\u201334 reverses bone loss in ovariectomized mice","volume":"16","author":"Alexander","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1677\/joe.0.1700529","article-title":"Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice","volume":"170","author":"Andersson","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2006.01.145_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0167-4889(03)00042-9","article-title":"Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells","volume":"1640","author":"Arai","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bone.2006.01.145_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/8756-3282(94)00036-Y","article-title":"Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats","volume":"16","author":"Baumann","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.145_bib5","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa031975","article-title":"The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis","volume":"349","author":"Black","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.145_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1359\/JBMR.041204","article-title":"beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice","volume":"20","author":"Bouxsein","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib7","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1359\/JBMR.050205","article-title":"Comparison insight bone measurements by histomorphometry and microCT","volume":"20","author":"Chappard","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1359\/jbmr.2001.16.5.925","article-title":"Parathyroid hormone added to established hormone therapy: effects on vertebral fracture and maintenance of bone mass after parathyroid hormone withdrawal","volume":"16","author":"Cosman","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib9","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1359\/jbmr.2001.16.10.1846","article-title":"Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study","volume":"16","author":"Dempster","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bone.2006.01.145_bib11","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1210\/en.2004-1282","article-title":"Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2","volume":"146","author":"Ferrari","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.01.145_bib12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa035725","article-title":"The effects of parathyroid hormone, alendronate, or both in men with osteoporosis","volume":"349","author":"Finkelstein","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.145_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000145910","article-title":"Effect of guanethidine-induced sympathectomy on osteoblastic activity in the rat femur evaluated by 3H-proline autoradiography","volume":"120","author":"Herskovits","year":"1984","journal-title":"Acta. Anat. (Basel)"},{"key":"10.1016\/j.bone.2006.01.145_bib14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01495739708936692","article-title":"Quantification of bone microarchitecture with the structure model index","volume":"1","author":"Hildebrand","year":"1997","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.bone.2006.01.145_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00319037","article-title":"Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat","volume":"264","author":"Hill","year":"1991","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bone.2006.01.145_bib17","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1359\/jbmr.1999.14.4.536","article-title":"Anabolic effects of human biosynthetic parathyroid hormone fragment (1\u201334), LY333334, on remodeling and mechanical properties of cortical bone in rabbits","volume":"14","author":"Hirano","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.3518059","article-title":"Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers","volume":"232","author":"Hohmann","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.bone.2006.01.145_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1385\/JCD:6:1:25","article-title":"Precision, accuracy, and reproducibility of dual X-ray absorptiometry measurements in mice in vivo","volume":"6","author":"Iida-Klein","year":"2003","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bone.2006.01.145_bib20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1359\/jbmr.2002.17.5.808","article-title":"Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice","volume":"17","author":"Iida-Klein","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib21","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1359\/jbmr.2003.18.11.1932","article-title":"Recombinant human parathyroid hormone (1\u201334) [teriparatide] improves both cortical and cancellous bone structure","volume":"18","author":"Jiang","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib22","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJMe038143","article-title":"Parathyroid hormone plus alendronate\u2014A combination that does not add up","volume":"349","author":"Khosla","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.145_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S8756-3282(00)00448-8","article-title":"Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1\u201334)","volume":"28","author":"Kneissel","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.145_bib24","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1210\/en.142.10.4295","article-title":"OPG and PTH-(1\u201334) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats","volume":"142","author":"Kostenuik","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.01.145_bib25","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0031-3203(96)00009-X","article-title":"Performance analysis for a class of iterative image thresholding algorithms","volume":"29","author":"Leung","year":"1996","journal-title":"Pattern Recogn."},{"key":"10.1016\/j.bone.2006.01.145_bib26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/jor.1100090613","article-title":"Effects of propranolol on bone metabolism in the rat","volume":"9","author":"Minkowitz","year":"1991","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S8756-3282(00)00355-0","article-title":"Comparison of bone formation responses to parathyroid hormone(1\u201334), (1\u201331), and (2\u201334) in mice","volume":"27","author":"Mohan","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.145_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0169-6009(08)80105-5","article-title":"Characterization of beta-adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture","volume":"23","author":"Moore","year":"1993","journal-title":"Bone Miner."},{"key":"10.1016\/j.bone.2006.01.145_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2362.1984.tb02095.x","article-title":"Effect of propranolol treatment on bone mass, bone mineral content, bone remodelling, parathyroid function and vitamin D metabolism in hyperthyroidism","volume":"14","author":"Mosekilde","year":"1984","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bone.2006.01.145_bib30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.01.145_bib31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1359\/jbmr.0301214","article-title":"Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study","volume":"19","author":"Pasco","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/JBMR.041202","article-title":"beta-blocker use, BMD, and fractures in the study of osteoporotic fractures","volume":"20","author":"Reid","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib34","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1210\/jc.2005-0573","article-title":"Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial","volume":"90","author":"Reid","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.01.145_bib35","first-page":"630","article-title":"Picture thresholding using an iterative selection method","author":"Ridler","year":"1978","journal-title":"IEEE Trans Syst. Man Cybern. SMC-8"},{"key":"10.1016\/j.bone.2006.01.145_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1359\/JBMR.041114","article-title":"Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling","volume":"20","author":"Riggs","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.145_bib37","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1001\/jama.292.11.1326","article-title":"Use of beta-blockers and risk of fractures","volume":"292","author":"Schlienger","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.01.145_bib38","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00296285","article-title":"Effects of combined and separate intermittent administration of low-dose human parathyroid hormone fragment (1\u201334) and 17 beta-estradiol on bone histomorphometry in ovariectomized rats with established osteopenia","volume":"50","author":"Shen","year":"1992","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.01.145_bib39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bone.2006.01.145_bib40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0006-2952(00)00591-8","article-title":"Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells","volume":"61","author":"Takeuchi","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bone.2006.01.145_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jemt.10121","article-title":"Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells","volume":"58","author":"Togari","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bone.2006.01.145_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(97)00649-6","article-title":"Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells","volume":"233","author":"Togari","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bone.2006.01.145_bib43","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S8756-3282(03)00057-7","article-title":"Anabolic action of parathyroid hormone on cortical and cancellous bone differs between axial and appendicular skeletal sites in mice","volume":"32","author":"Zhou","year":"2003","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206002006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206002006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T21:50:43Z","timestamp":1547761843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328206002006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S8756328206002006"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.01.145","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}