{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:33:56Z","timestamp":1791023636223,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bone.2006.01.161","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T07:59:09Z","timestamp":1143705549000},"page":"345-352","source":"Crossref","is-referenced-by-count":138,"title":["Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: Sequential triple biopsy studies with micro-computed tomography"],"prefix":"10.1016","volume":"39","author":[{"given":"B.","family":"Borah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Dufresne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Ritman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Chmielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Sibonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.T.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.01.161_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinthera.2004.12.020","article-title":"The bone quality frame work: determinants of bone strength and their interrelationships, and implications for osteoporosis management","volume":"27","author":"Felsenberg","year":"2005","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bone.2006.01.161_bib2","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1007\/s00198-003-1489-x","article-title":"Bone quality: where do we go from here?","volume":"14","author":"Bouxsein","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.161_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1359\/jbmr.2002.17.1.11","article-title":"Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density","volume":"17","author":"Riggs","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.161_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S8756-3282(03)00236-9","article-title":"Is the paradigm shifting?","volume":"33","author":"Heaney","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S8756-3282(02)00975-4","article-title":"Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white females","volume":"32","author":"Ciarelli","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1098\/rstb.1984.0042","article-title":"Effects of differences in mineralization on the mechanical properties of bone","volume":"304","author":"Currey","year":"1984","journal-title":"Philos. Trans. R. Soc. Lond., B Biol. Sci."},{"issue":"Suppl. 5","key":"10.1016\/j.bone.2006.01.161_bib7","first-page":"S29","article-title":"The role of collagen and other organics in the mechanical properties of bone","volume":"14","author":"Currey","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.161_bib8","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/8756-3282(92)90196-4","article-title":"Implications of architecture for the pathogenesis and prevention of vertebral fracture","volume":"13","author":"Parfitt","year":"1992","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib9","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1359\/jbmr.2002.17.7.1139","article-title":"Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by 3-dimensional micro-computed tomography","volume":"17","author":"Borah","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2006.01.161_bib10","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/jbmr.5650110516","article-title":"Altered trabecular architecture induced by corticosteroids: a bone histomorphometric study","volume":"11","author":"Chappard","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.161_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S8756-3282(99)00098-8","article-title":"The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone","volume":"25","author":"Ulrich","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jama.282.14.1344","article-title":"Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial","volume":"282","author":"Harris","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.01.161_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2006.01.161_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S8756-3282(02)00946-8","article-title":"Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience","volume":"32","author":"Sorensen","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00223-003-0042-4","article-title":"Risedronate rapidly reduces the risk for nonvertebral fractures in women with postmenopausal osteoporosis","volume":"74","author":"Harrington","year":"2004","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.bone.2006.01.161_bib16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1185\/030079903125003125","article-title":"Efficacy of risedronate on clinical vertebral fractures within six months","volume":"20","author":"Roux","year":"2004","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.bone.2006.01.161_bib17","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/jbmr.2003.18.6.1051","article-title":"Relationship of early changes in bone resorption to the reduction of fracture risk with risedronate","volume":"18","author":"Eastell","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.161_bib18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bone.2003.12.013","article-title":"Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional micro-computed tomography","volume":"34","author":"Borah","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2005.03.017","article-title":"The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover","volume":"37","author":"Borah","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib20","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S8756-3282(02)00869-4","article-title":"Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis","volume":"31","author":"Eriksen","year":"2002","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2006.01.161_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00223-004-0039-7","article-title":"Five years of treatment with risedronate and its effect on bone safety in women with postmenopausal osteoporosis","volume":"75","author":"Ste-Marie","year":"2004","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.01.161_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/jcem-67-4-741","article-title":"Bone formation rate in older women: concurrent assessment with bone histomorphometry, calcium kinetics and biochemical markers","volume":"67","author":"Eastell","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.01.161_bib23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1359\/jbmr.2002.17.8.1372","article-title":"Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment","volume":"17","author":"Nuzzo","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.161_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1117\/12.279356","article-title":"Synchrotron-based micro-CT of in situ biological basic functional units and their integration","volume":"3149","author":"Ritman","year":"1997","journal-title":"SPIE"},{"key":"10.1016\/j.bone.2006.01.161_bib25","first-page":"55","article-title":"Estimation of basic stereological parameters","volume":"vol. 2","author":"Weibel","year":"1989"},{"key":"10.1016\/j.bone.2006.01.161_bib26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00223-002-2104-4","article-title":"Risedronate preserves bone architecture in early postmenopausal women in 1\u00a0year as measured by three-dimensional microcomputed tomography","volume":"73","author":"Dufresne","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.01.161_bib27","series-title":"Bone histomorphometry: techniques and interpretation","first-page":"143","article-title":"The physiologic and clinical significance of bone histomorphometric data","author":"Parfitt","year":"1983"},{"key":"10.1016\/j.bone.2006.01.161_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02012537","article-title":"Quantitative analysis on the rate of secondary mineralization","volume":"10","author":"Marotti","year":"1972","journal-title":"Calcif. Tissue Res."},{"key":"10.1016\/j.bone.2006.01.161_bib29","series-title":"The spine","first-page":"775","article-title":"Metabolic bone disease affecting the spine","author":"Parfitt","year":"1982"},{"key":"10.1016\/j.bone.2006.01.161_bib30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/03008200290000934","article-title":"Changes in bone remodeling rate influence the degree of mineralization of bone","volume":"43","author":"Boivin","year":"2002","journal-title":"Connect. Tissue Res."},{"issue":"6","key":"10.1016\/j.bone.2006.01.161_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00223-004-0286-7","article-title":"Seven years of treatment with risedronate in women with postmenopausal osteoporosis","volume":"75","author":"Mellstrom","year":"2004","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.01.161_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jbmr.5650100319","article-title":"Relations between histologic indices of bone formations: implications for the pathogenesis of osteoporosis","volume":"10","author":"Parfitt","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.01.161_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1359\/jbmr.2002.17.2.341","article-title":"Bone histomorphometric and biochemical marker results of a 2-year placebo-controlled trial of raloxifene in postmenopausal women","volume":"17","author":"Ott","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2006.01.161_bib34","first-page":"S420","article-title":"Effect of 3 and 5\u00a0year treatment with risedronate on the bone mineralization density distribution of cancellous bone in human iliac crest biopsies","volume":"36","author":"Zoehrer","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S8756-3282(01)00485-9","article-title":"Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women","volume":"29","author":"Roschger","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.01.161_bib36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S8756-3282(00)00376-8","article-title":"Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women","volume":"27","author":"Boivin","year":"2000","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2006.01.161_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1185\/030079904X20259","article-title":"Trabecular bone microarchitecture after alendronate treatment of osteoporotic women","volume":"21","author":"Recker","year":"2005","journal-title":"Curr. Med. Res. Opin."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820600202X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820600202X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T05:56:09Z","timestamp":1547704569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632820600202X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S875632820600202X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.01.161","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}