{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:35:09Z","timestamp":1790516109008,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.bone.2006.04.006","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T21:11:45Z","timestamp":1149196305000},"page":"767-772","source":"Crossref","is-referenced-by-count":44,"title":["Alteration of femoral bone morphology and density in COX-2\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"39","author":[{"given":"Galen","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis J.","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Guldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.04.006_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1359\/JBMR.041124","article-title":"Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene","volume":"20","author":"Alam","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbmr.5650110106","article-title":"Aspirin and NSAID use in older women: effect on bone mineral density and fracture risk. Study of Osteoporotic Fractures Research Group","volume":"11","author":"Bauer","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib3","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1359\/jbmr.1999.14.12.2159","article-title":"Growing C57Bl\/6 mice increase whole bone mechanical properties by increasing geometric and material properties","volume":"14","author":"Brodt","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00223-002-0009-x","article-title":"Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice","volume":"73","author":"Chen","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2006.04.006_bib5","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1359\/jbmr.2002.17.8.1430","article-title":"Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo","volume":"17","author":"Chikazu","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00302070","article-title":"Mechanotransduction and the functional response of bone to mechanical strain","volume":"57","author":"Duncan","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2006.04.006_bib7","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/jbmr.5650111112","article-title":"Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo","volume":"11","author":"Forwood","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib8","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0736-0266(02)00079-7","article-title":"COX-2 selective NSAID decreases bone ingrowth in vivo","volume":"20","author":"Goodman","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.bone.2006.04.006_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0005-2760(95)00194-8","article-title":"Prostaglandin synthase 2","volume":"1229","author":"Herschman","year":"1996","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.bone.2006.04.006_bib10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01495739708936692","article-title":"Quantification of bone microarchitecture with the structure model index","volume":"1","author":"Hildebrand","year":"1997","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"10.1016\/j.bone.2006.04.006_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0169-6009(91)90109-D","article-title":"Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats","volume":"15","author":"Jee","year":"1991","journal-title":"Bone Miner"},{"key":"10.1016\/j.bone.2006.04.006_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/15419060109080738","article-title":"Mechanical stimulation of gap junctions in bone osteocytes is mediated by prostaglandin E2","volume":"8","author":"Jiang","year":"2001","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.bone.2006.04.006_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1359\/JBMR.040110","article-title":"Genetically linked site-specificity of disuse osteoporosis","volume":"19","author":"Judex","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1359\/JBMR.040101","article-title":"Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology","volume":"19","author":"Judex","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI118066","article-title":"Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae","volume":"96","author":"Kawaguchi","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2006.04.006_bib17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1210\/en.135.3.1157","article-title":"Regulation of the two prostaglandin G\/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae","volume":"135","author":"Kawaguchi","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.006_bib18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/bbrc.1998.8632","article-title":"Mechanotransduction in stretched osteocytes\u2014temporal expression of immediate early and other genes","volume":"246","author":"Kawata","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2006.04.006_bib19","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1359\/jbmr.1998.13.11.1648","article-title":"Quantitative trait loci affecting peak bone mineral density in mice","volume":"13","author":"Klein","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib20","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.1016\/S0021-9258(18)98774-0","article-title":"TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase\/cyclooxygenase homologue","volume":"266","author":"Kujubu","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2006.04.006_bib21","first-page":"1132","article-title":"Aspirin and nonsteroidal antiinflammatory drug use in elderly women: effects on a marker of bone resorption. The Study of Osteoporotic Fractures Research Group","volume":"24","author":"Lane","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.bone.2006.04.006_bib22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0092-8674(95)90126-4","article-title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","volume":"83","author":"Langenbach","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bone.2006.04.006_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s007740050065","article-title":"Mechanical responses and signal transduction pathways in stretched osteocytes","volume":"17","author":"Mikuni-Takagaki","year":"1999","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bone.2006.04.006_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90125-6","article-title":"Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse","volume":"83","author":"Morham","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bone.2006.04.006_bib25","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1359\/jbmr.1998.13.12.1924","article-title":"Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study","volume":"13","author":"Morton","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib26","doi-asserted-by":"crossref","first-page":"23261","DOI":"10.1016\/S0021-9258(18)54491-4","article-title":"A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein","volume":"266","author":"O'Banion","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2006.04.006_bib27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1172\/JCI8195","article-title":"Prostaglandin G\/H synthase-2 is required for maximal formation of osteoclast-like cells in culture","volume":"105","author":"Okada","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2006.04.006_bib28","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1359\/jbmr.2001.16.11.1962","article-title":"Sex specificity in the genetic determinants of peak bone mass","volume":"16","author":"Orwoll","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib29","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1210\/en.138.11.4672","article-title":"Transforming growth factor-beta1 regulation of prostaglandin G\/H synthase-2 expression in osteoblastic MC3T3-E1 cells","volume":"138","author":"Pilbeam","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.006_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1053\/joca.1998.0230","article-title":"Prostaglandins and bone: physiology and pathophysiology","volume":"7","author":"Raisz","year":"1999","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.bone.2006.04.006_bib31","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/endo-126-2-1076","article-title":"Effects of prostaglandin F2 alpha on bone formation and resorption in cultured neonatal mouse calvariae: role of prostaglandin E2 production","volume":"126","author":"Raisz","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.006_bib32","first-page":"S20","article-title":"The effects of cyclooxygenase-2 inhibitors on bone mineral density: results from the CaMos study","volume":"20","author":"Richards","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1359\/jbmr.2002.17.6.963","article-title":"Cyclo-oxygenase 2 function is essential for bone fracture healing","volume":"17","author":"Simon","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib34","doi-asserted-by":"crossref","first-page":"11586","DOI":"10.1016\/S0021-9258(19)49951-1","article-title":"Hormona regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat prevulatory follicles. Induction in vivo and in vitro","volume":"267","author":"Sirois","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2006.04.006_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00223-003-0101-x","article-title":"Growth of C57BL\/6 mice and the material and mechanical properties of cortical bone from the tibia","volume":"74","author":"Somerville","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2006.04.006_bib36","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1210\/en.137.12.5435","article-title":"Parathyroid hormone induces prostaglandin G\/H synthase-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in the murine osteoblastic cell line MC3T3-E1","volume":"137","author":"Tetradis","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.006_bib37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-291X(02)02124-1","article-title":"Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway","volume":"297","author":"Wadhwa","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2006.04.006_bib38","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1359\/jbmr.2002.17.2.266","article-title":"Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway","volume":"17","author":"Wadhwa","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1006\/bbrc.1999.1606","article-title":"Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts","volume":"264","author":"Wadleigh","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bone.2006.04.006_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S8756-3282(00)00447-6","article-title":"Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue","volume":"28","author":"Weinreb","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.006_bib41","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1210\/en.2004-0734","article-title":"Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism?","volume":"146","author":"Xu","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.006_bib42","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1359\/jbmr.2001.16.4.660","article-title":"Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis","volume":"16","author":"Zhang","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2006.04.006_bib43","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1172\/JCI0215681","article-title":"Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair","volume":"109","author":"Zhang","year":"2002","journal-title":"J Clin Invest"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206004273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206004273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T23:03:33Z","timestamp":1627427013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328206004273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S8756328206004273"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.04.006","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}