{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:35:36Z","timestamp":1791178536308,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.bone.2006.04.012","type":"journal-article","created":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T10:26:31Z","timestamp":1150021591000},"page":"773-786","source":"Crossref","is-referenced-by-count":54,"title":["Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin"],"prefix":"10.1016","volume":"39","author":[{"given":"Peter S.N.","family":"Rowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oak D.","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi N.J.","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine","family":"Oconnor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine P.","family":"Roudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimoto","family":"Yanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.04.012_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/geno.2001.6553","article-title":"Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone","volume":"74","author":"Argiro","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.bone.2006.04.012_bib2","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1210\/me.2002-0113","article-title":"Partial rescue of the hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression","volume":"16","author":"Bai","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bone.2006.04.012_bib3","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1074\/jbc.M210490200","article-title":"The autosomal dominant hypophosphatemic rickets R176Q mutation in FGF23 resists proteolytic cleavage and enhances in vivo biological potency","volume":"278","author":"Bai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10520299009108065","article-title":"Cement line staining in undecalcified thin sections of cortical bone","volume":"65","author":"Bain","year":"1990","journal-title":"Stain Technol."},{"key":"10.1016\/j.bone.2006.04.012_bib5","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","author":"Beck","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2006.04.012_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI18563","article-title":"Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent","volume":"112","author":"Berndt","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2006.04.012_bib7","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.1.05989","article-title":"Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets","volume":"183","author":"Bresler","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2006.04.012_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0031-3955(05)70485-5","article-title":"New perspectives on the biology and treatment of X-linked hypophosphatemic rickets","volume":"44","author":"Carpenter","year":"1997","journal-title":"Pediatr. Clin. North Am."},{"key":"10.1016\/j.bone.2006.04.012_bib9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1210\/jc.2004-0357","article-title":"FGF7\u2014An inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors","volume":"90","author":"Carpenter","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib10","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1210\/en.137.12.5213","article-title":"Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels","volume":"137","author":"Carpenter","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib11","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1210\/jc.81.6.2381","article-title":"24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets\u2014A clinical research center study","volume":"81","author":"Carpenter","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/en.139.1.35","article-title":"Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice","volume":"139","author":"Carpenter","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1359\/jbmr.2003.18.4.644","article-title":"Renal calcification in mice homozygous for the disrupted type IIa Na\/Pi cotransporter gene Npt2","volume":"18","author":"Chau","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1210\/en.130.1.328","article-title":"Altered proximal tubule glucose metabolism in X-linked hypophosphatemic mice","volume":"130","author":"Capparelli","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib15","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1210\/endo-128-3-1270","article-title":"Variable phosphate-mediated regulation of vitamin D metabolism in the murine hypophosphatemic rachitic\/osteomalacic disorders","volume":"128","author":"Davidai","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib16","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1359\/jbmr.2002.17.6.1102","article-title":"Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism","volume":"17","author":"De Beur","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib17","first-page":"468A","article-title":"Infusion of the bone-derived protein MEPE causes phosphaturia in rats (Abstract)","volume":"14","author":"Dobbie","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2006.04.012_bib18","doi-asserted-by":"crossref","unstructured":"M.K. Drezner, PHEX gene and hypophosphatemia. Kidney Int. 2000.Jan.;57.(1.):9.-18. 57:9\u201318; 2000.","DOI":"10.1046\/j.1523-1755.2000.00807.x"},{"key":"10.1016\/j.bone.2006.04.012_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/978-1-4684-4808-5_48","article-title":"The role of abnormal vitamin D metabolism in X-linked hypophosphatemic rickets and osteomalacia","volume":"178","author":"Drezner","year":"1984","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bone.2006.04.012_bib20","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1172\/JCI109930","article-title":"Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia","volume":"66","author":"Drezner","year":"1980","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2006.04.012_bib21","doi-asserted-by":"crossref","first-page":"C1414","DOI":"10.1152\/ajpcell.00135.2002","article-title":"Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport","volume":"283","author":"Dubois","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1210\/endo-123-2-768","article-title":"Defective bone formation by transplanted Hyp mouse bone cells into normal mice","volume":"123","author":"Ecarot-Charrier","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib23","first-page":"E33","article-title":"Phosphate transport by osteoblasts from X-linked hypophosphatemic mice","volume":"266","author":"Ecarot","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jbmr.5650070213","article-title":"Defective bone formation by Hyp mouse bone cells transplanted into normal mice: evidence in favor of an intrinsic osteoblast defect","volume":"7","author":"Ecarot","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib25","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jbmr.5650100313","article-title":"Effect of 1,25-dihydroxyvitamin D3 treatment on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice","volume":"10","author":"Ecarot","year":"1995","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2006.04.012_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/jbmr.5650070508","article-title":"Effect of dietary phosphate deprivation and supplementation of recipient mice on bone formation by transplanted cells from normal and X-linked hypophosphataemic mice","volume":"7","author":"Ecarot","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1359\/JBMR.050212","article-title":"Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype","volume":"20","author":"Erben","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib28","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1096\/fj.03-0966fje","article-title":"Three small integrin-binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases","volume":"18","author":"Fedarko","year":"2004","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bone.2006.04.012_bib29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1101\/gr.7.6.573","article-title":"Genomic organisation of the human PEX gene mutated in X-linked dominant hypophosphataemic rickets","volume":"7","author":"Francis","year":"1997","journal-title":"Gen. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib30","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1074\/jbc.M203250200","article-title":"Targeted disruption of the osteoblast\/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass","volume":"278","author":"Gowen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib31","doi-asserted-by":"crossref","first-page":"E837","DOI":"10.1152\/ajpendo.2001.281.4.E837","article-title":"Analysis of recombinant Phex: an endopeptidase in search of a substrate","volume":"281","author":"Guo","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0006-291X(02)02125-3","article-title":"Inhibition of MEPE cleavage by Phex","volume":"297","author":"Guo","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2006.04.012_bib33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S8756-3282(01)00601-9","article-title":"Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2\u2212\/\u2212 mice","volume":"29","author":"Gupta","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.012_bib34","first-page":"E141","article-title":"Comparison of 22-oxacalcitriol and 1,25(OH)2D3 on bone metabolism in young X-linked hypophosphatemic male mice","volume":"270","author":"Halstead","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib35","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI111900","article-title":"Healing of bone disease in X-linked hypophosphatemic rickets\/osteomalacia. Induction and maintenance with phosphorus and calcitriol","volume":"75","author":"Harrell","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2006.04.012_bib36","first-page":"F357","article-title":"X-linked hypophosphatemic rickets and the murine Hyp homologue","volume":"268","author":"Hruska","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng1095-130","article-title":"A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium","volume":"11","author":"HYP-consortium","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2006.04.012_bib38","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1681\/ASN.2005050573","article-title":"Fibroblast growth factor 23: roles in health and disease","volume":"16","author":"Imel","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2006.04.012_bib39","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/jc.2003-032031","article-title":"Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density","volume":"89","author":"Jain","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib40","first-page":"F479","article-title":"Matrix extracellular phosphoglycoprotein (MEPE), fragments circulate in excess in patients with tumor-induced osteomalacia (TIO) and X-linked hypophosphatemic rickets (XLH)","volume":"19","author":"Jan de Beur","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib41","first-page":"408A","article-title":"Cathepsin D (Cat D) and bone defect in hypophosphatemic (Hyp) mice [Abstract]","volume":"11","author":"Jo","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2006.04.012_bib42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbrc.2005.04.116","article-title":"Altered cathepsin D metabolism in Phex antisense human osteoblast cells","volume":"332","author":"Matsumoto","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2006.04.012_bib43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1096\/fasebj.1.6.3315809","article-title":"Trafficking of lysosomal enzymes","volume":"1","author":"Kornfeld","year":"1987","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2006.04.012_bib44","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1359\/JBMR.050815","article-title":"DMP1 Depletion decreases bone mineralization in vivo: an FTIR imaging analysis","volume":"20","author":"Ling","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib45","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1681\/ASN.2004121060","article-title":"Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia","volume":"16","author":"Liu","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2006.04.012_bib46","doi-asserted-by":"crossref","first-page":"37419","DOI":"10.1074\/jbc.M304544200","article-title":"Regulation of FGF23 expression but not degradation by phex","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib47","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1074\/jbc.M107707200","article-title":"Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype","volume":"277","author":"Liu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1210\/jcem-54-2-307","article-title":"The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia","volume":"54","author":"Lyles","year":"1982","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF02411227","article-title":"Bone response to phosphate and vitamin D metabolites in the hypophosphatemic male mouse","volume":"34","author":"Marie","year":"1982","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.04.012_bib50","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1210\/endo-111-3-904","article-title":"Healing of bone lesions with 1,25-dihydroxyvitamin D3 in the young X-linked hypophosphataemic male mouse","volume":"111","author":"Marie","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib51","doi-asserted-by":"crossref","first-page":"E123","DOI":"10.1152\/ajpendo.00562.2004","article-title":"Increased cathepsin D release by Hyp mouse osteoblast cells","volume":"289","author":"Matsumoto","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jbmr.5650110402","article-title":"Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats","volume":"11","author":"Meng","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib53","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bone.2003.12.015","article-title":"Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice","volume":"34","author":"Miao","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.012_bib54","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1210\/en.142.2.926","article-title":"Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition","volume":"142","author":"Miao","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib55","first-page":"15","article-title":"Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone","volume":"15","author":"Murshed","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2006.04.012_bib56","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1359\/jbmr.1999.14.12.2027","article-title":"Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in X-linked hypophosphatemia","volume":"14","author":"Nesbitt","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0003-9861(88)90104-X","article-title":"Identification of latent procathepsins B and L in microsomal lumen: characterization of enzymatic activation and proteolytic processing in vitro","volume":"261","author":"Nishimura","year":"1988","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bone.2006.04.012_bib58","first-page":"7","article-title":"Dentinal defects in Hyp mice not caused by hypophosphatemia alone","volume":"7","author":"Ogawa","year":"2005","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bone.2006.04.012_bib59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1523-1755.2005.00389.x","article-title":"Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)","volume":"68","author":"Ogbureke","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2006.04.012_bib60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1442-200X.1997.tb03628.x","article-title":"Medical management and complications of X-linked hypophosphatemic vitamin D resistant rickets","volume":"39","author":"Ono","year":"1997","journal-title":"Acta Paediatr. Jpn."},{"key":"10.1016\/j.bone.2006.04.012_bib61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib62","doi-asserted-by":"crossref","first-page":"36172","DOI":"10.1074\/jbc.M003622200","article-title":"Identification of osteoblast\/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes","volume":"275","author":"Petersen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib63","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002239900331","article-title":"Skeletal casein kinase activity defect in the HYP mouse","volume":"61","author":"Rifas","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.04.012_bib64","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF00334333","article-title":"Phosphate transport in osteoblasts from normal and X-linked hypophosphatemic mice","volume":"54","author":"Rifas","year":"1994","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.04.012_bib65","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF00298998","article-title":"Altered osteoblast gluconeogenesis in X-linked hypophosphatemic mice is associated with a depressed intracellular pH","volume":"57","author":"Rifas","year":"1995","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.04.012_bib66","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/adc.83.3.192","article-title":"The molecular background to hypophosphataemic rickets","volume":"83","author":"Rowe","year":"2000","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.bone.2006.04.012_bib67","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/154411130401500503","article-title":"The wrickkened-pathways of FGF23, MEPE and PHEX","volume":"15","author":"Rowe","year":"2004","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"1","key":"10.1016\/j.bone.2006.04.012_bib68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/geno.2000.6235","article-title":"MEPE, a new gene expressed in bone-marrow and tumours causing osteomalacia","volume":"67","author":"Rowe","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.bone.2006.04.012_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bone.2004.09.015","article-title":"Surface plasmon resonance (SPR) confirms MEPE binds to PHEX via the MEPE-ASARM-motif: a model for impaired mineralization in X-linked rickets (HYP)","volume":"36","author":"Rowe","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.012_bib70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02185769","article-title":"The gene for X-linked hypophosphataemic rickets maps to a 200\u2013300\u00a0kb region in Xp22.1, and is located on a single YAC containing a putative vitamin D response element (VDRE)","volume":"97","author":"Rowe","year":"1996","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bone.2006.04.012_bib71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bone.2003.10.005","article-title":"MEPE has the properties of an osteoblastic Phosphatonin and Minhibin","volume":"34","author":"Rowe","year":"2004","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2006.04.012_bib72","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/8756-3282(95)00458-0","article-title":"Candidate 56 and 58\u00a0kDa protein(s) responsible for mediating the renal defects in oncogenic hypophosphataemic osteomalacia","volume":"18","author":"Rowe","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.012_bib73","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/hmg\/6.4.539","article-title":"Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP)","volume":"6","author":"Rowe","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2006.04.012_bib74","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa010839","article-title":"Octreotide therapy for tumor-induced osteomalacia","volume":"345","author":"Seufert","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.04.012_bib75","series-title":"Theory and practice of histotechnology","author":"Sheehan","year":"1987"},{"key":"10.1016\/j.bone.2006.04.012_bib76","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1681\/ASN.V132394","article-title":"Effects of PHEX antisense in human osteoblast cells","volume":"13","author":"Shih","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2006.04.012_bib77","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2006.04.012_bib78","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/en.143.8.3179","article-title":"Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo","volume":"143","author":"Shimada","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.04.012_bib79","doi-asserted-by":"crossref","first-page":"F675","DOI":"10.1152\/ajprenal.00362.2003","article-title":"1{alpha}-Hydroxylase gene ablation and Pi supplementation inhibit renal calcification in mice homozygous for the disrupted Na\/Pi cotransporter gene Npt2a","volume":"286","author":"Tenenhouse","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib80","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJM198701153160302","article-title":"\u201cIdiopathic\u201d hypercalciuria and hereditary hypophosphatemic rickets. Two phenotypical expressions of a common genetic defect","volume":"316","author":"Tieder","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.04.012_bib81","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ndt\/16.1.48","article-title":"Autosomal recessive hypophosphataemic rickets with hypercalciuria is not caused by mutations in the type II renal sodium\/phosphate cotransporter gene","volume":"16","author":"van den Heuvel","year":"2001","journal-title":"Nephrol. Dial Transplant"},{"key":"10.1016\/j.bone.2006.04.012_bib82","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1359\/jbmr.2003.18.7.1227","article-title":"Serum FGF23 levels in normal and disordered phosphorus homeostasis","volume":"18","author":"Weber","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.04.012_bib83","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","author":"White","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2006.04.012_bib84","first-page":"E700","article-title":"Intrinsic mineralization defect in Hyp mouse osteoblasts","volume":"275","author":"Xiao","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bone.2006.04.012_bib85","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/8756-3282(92)90199-7","article-title":"Abnormal response of osteoblasts from Hyp mice to 1,25-Dihydroxyvitamin D3","volume":"13","author":"Yamamoto","year":"1992","journal-title":"Bone"},{"key":"10.1016\/j.bone.2006.04.012_bib86","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1210\/jc.2002-021105","article-title":"Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets\/osteomalacia","volume":"87","author":"Yamazaki","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.04.012_bib87","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1074\/jbc.M412911200","article-title":"Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype","volume":"280","author":"Ye","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2006.04.012_bib88","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cytogfr.2005.01.002","article-title":"FGF23 and disorders of phosphate homeostasis","volume":"16","author":"Yu","year":"2005","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206004170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206004170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T03:10:43Z","timestamp":1627441843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328206004170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S8756328206004170"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.04.012","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}