{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:25:49Z","timestamp":1768447549555,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009810","name":"Wera Ekstr\u00f6ms Stiftelse f\u00f6r Pediatrisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006741","name":"Stiftelsen Frimurare Barnhuset i Stockholm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009757","name":"H.K.H. Kronprinsessan Lovisas F\u00f6rening f\u00f6r Barnasjukv\u00e5rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.bone.2006.12.066","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T10:27:03Z","timestamp":1168424823000},"page":"1415-1424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones"],"prefix":"10.1016","volume":"40","author":[{"given":"Andrei S.","family":"Chagin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Karimian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farasat","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Takigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionisios","family":"Chrysis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"S\u00e4vendahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2006.12.066_bib1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJM199808273390905","article-title":"Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency","volume":"339","author":"Bilezikian","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.12.066_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.1.06364","article-title":"Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis","volume":"188","author":"Chagin","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2006.12.066_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.1.06364","article-title":"Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis","volume":"188","author":"Chagin","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2006.12.066_bib4","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1210\/en.2004-1152","article-title":"Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3\u2032-kinase signaling pathway","volume":"146","author":"Chrysis","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.12.066_bib5","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1001\/jama.283.10.1318","article-title":"Monitoring osteoporosis therapy with bone densitometry: misleading changes and regression to the mean. Fracture Intervention Trial Research Group","volume":"283","author":"Cummings","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2006.12.066_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bone.2006.12.066_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1210\/endo.142.1.7901","article-title":"Regulation of growth plate chondrogenesis by bone morphogenetic protein-2","volume":"142","author":"De Luca","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.12.066_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1515\/IJAMH.2003.15.4.359","article-title":"Tamoxifen treatment for pubertal gynecomastia","volume":"15","author":"Derman","year":"2003","journal-title":"Int. J. Adolesc. Med. Health"},{"key":"10.1016\/j.bone.2006.12.066_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0022-3476(03)00128-8","article-title":"Tamoxifen treatment for precocious puberty in McCune\u2013Albright syndrome: a multicenter trial","volume":"143","author":"Eugster","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bone.2006.12.066_bib10","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1182\/blood.V92.12.4808","article-title":"Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species","volume":"92","author":"Fadeel","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bone.2006.12.066_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.bjc.6690042","article-title":"Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines","volume":"79","author":"Ferlini","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bone.2006.12.066_bib12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/j.1939-4640.2004.tb02823.x","article-title":"Comparison of tamoxifen and testosterone propionate in male rats: differential prevention of orchidectomy effects on sex organs, bone mass, growth, and the growth hormone\u2013IGF-I axis","volume":"25","author":"Fitts","year":"2004","journal-title":"J. Androl."},{"key":"10.1016\/j.bone.2006.12.066_bib13","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1210\/endo.142.10.8445","article-title":"Estrogen and tamoxifen interplay with T(3) in male rats: pharmacologically distinct classes of estrogen responses affecting growth, bone, and lipid metabolism, and their relation to serum GH and IGF-I","volume":"142","author":"Fitts","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.12.066_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/cmt.4.3.181.193","article-title":"Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9\u201312 June 2001, Opera del Duomo, Pisa, Italy","volume":"4","author":"Genazzani","year":"2001","journal-title":"Climacteric"},{"key":"10.1016\/j.bone.2006.12.066_bib15","first-page":"5147","article-title":"Drug and hormone sensitivity of estrogen receptor-positive and -negative human breast cancer cells in vitro","volume":"42","author":"Goldenberg","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2006.12.066_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1210\/jcem-16-2-249","article-title":"Treatment of excessive growth in the adolescent female","volume":"16","author":"Goldzieher","year":"1956","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.12.066_bib17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with Bax activation","volume":"423","author":"Guo","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bone.2006.12.066_bib18","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1158\/1078-0432.CCR-03-0538","article-title":"Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial","volume":"10","author":"Kisanga","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bone.2006.12.066_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0960-0760(03)00051-7","article-title":"Tamoxifen administration and metabolism in nude mice and nude rats","volume":"84","author":"Kisanga","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2006.12.066_bib20","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1542\/peds.2005-0577","article-title":"The use of tamoxifen to improve height potential in short pubertal boys","volume":"116","author":"Kreher","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.bone.2006.12.066_bib21","first-page":"2421","article-title":"Localization of estrogen receptor-alpha in human and rabbit skeletal tissues","volume":"83","author":"Kusec","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.12.066_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpeds.2004.03.057","article-title":"Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia","volume":"145","author":"Lawrence","year":"2004","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bone.2006.12.066_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s002239900122","article-title":"The effect of tamoxifen on bone metabolism and skeletal growth is different in ovariectomized and intact rats","volume":"59","author":"Li","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2006.12.066_bib24","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1056\/NEJM199203263261302","article-title":"Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer","volume":"326","author":"Love","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.12.066_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1023\/A:1012437607881","article-title":"Mechanisms of tamoxifen-induced apoptosis","volume":"6","author":"Mandlekar","year":"2001","journal-title":"Apoptosis"},{"key":"10.1016\/j.bone.2006.12.066_bib26","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1359\/JBMR.040805","article-title":"Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones","volume":"19","author":"Martensson","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2006.12.066_bib27","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1071884","article-title":"Connections and regulation of the human estrogen receptor","volume":"296","author":"McDonnell","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bone.2006.12.066_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2004.02855.x","article-title":"Activated JNK brings about accelerated apoptosis of Bcl-2-overexpressing C6 glioma cells on treatment with tamoxifen","volume":"92","author":"Moodbidri","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bone.2006.12.066_bib29","first-page":"3689","article-title":"Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens","volume":"80","author":"Morishima","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.12.066_bib30","first-page":"370","article-title":"Demonstration of estrogen receptor-beta immunoreactivity in human growth plate cartilage","volume":"84","author":"Nilsson","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2006.12.066_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1677\/joe.0.1730407","article-title":"Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate","volume":"173","author":"Nilsson","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2006.12.066_bib32","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1210\/en.2002-221108","article-title":"Raloxifene acts as an estrogen agonist on the rabbit growth plate","volume":"144","author":"Nilsson","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.12.066_bib33","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1210\/en.2004-1114","article-title":"Tamoxifen stimulates cancellous bone formation in long bones of female mice","volume":"146","author":"Perry","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2006.12.066_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF02307030","article-title":"Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells","volume":"2","author":"Perry","year":"1995","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.bone.2006.12.066_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0090-9556(25)07102-8","article-title":"Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient","volume":"19","author":"Robinson","year":"1991","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bone.2006.12.066_bib36","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/emboj\/17.6.1675","article-title":"Two CD95 (APO-1\/Fas) signaling pathways","volume":"17","author":"Scaffidi","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2006.12.066_bib37","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1056\/NEJM199410203311604","article-title":"Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man","volume":"331","author":"Smith","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2006.12.066_bib38","first-page":"3996","article-title":"Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes","volume":"49","author":"Takigawa","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2006.12.066_bib39","doi-asserted-by":"crossref","first-page":"pe44","DOI":"10.1126\/stke.3582006pe44","article-title":"Caspase inhibitors promote alternative cell death pathways","volume":"2006","author":"Vandenabeele","year":"2006","journal-title":"Sci. STKE"},{"key":"10.1016\/j.bone.2006.12.066_bib40","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(04)17274-7","article-title":"Oestrogen treatment to reduce the adult height of tall girls: long-term effects on fertility","volume":"364","author":"Venn","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2006.12.066_bib41","doi-asserted-by":"crossref","first-page":"29964","DOI":"10.1074\/jbc.M500710200","article-title":"Fas binding to calmodulin regulates apoptosis in osteoclasts","volume":"280","author":"Wu","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206009197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328206009197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:36:51Z","timestamp":1762659411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328206009197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S8756328206009197"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2006.12.066","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2006.12.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}