{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:42:18Z","timestamp":1788428538520,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.bone.2007.02.028","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T20:40:43Z","timestamp":1176324043000},"page":"13-18","source":"Crossref","is-referenced-by-count":17,"title":["PTH has the potential to rescue disturbed bone growth in achondroplasia"],"prefix":"10.1016","volume":"41","author":[{"given":"Koso","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Seino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2007.02.028_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bone.2003.08.009","article-title":"Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development","volume":"34","author":"Amizuka","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2007.02.028_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.136.1.205","article-title":"Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development","volume":"136","author":"Amling","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2007.02.028_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1432-1033.1992.tb16919.x","article-title":"Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10","volume":"206","author":"Apte","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bone.2007.02.028_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1096-8628(19990702)85:1<53::AID-AJMG10>3.0.CO;2-F","article-title":"Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3","volume":"85","author":"Bellus","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng0795-357","article-title":"A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia","volume":"10","author":"Bellus","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib6","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1172\/JCI6690","article-title":"Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis","volume":"104","author":"Chen","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2007.02.028_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","article-title":"Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3","volume":"12","author":"Colvin","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1043-2760(98)00120-9","article-title":"Control of bone growth by fibroblast growth factors","volume":"10","author":"De Luca","year":"1999","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2007.02.028_bib9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","article-title":"Fibroblast growth factor receptor 3 is a negative regulator of bone growth","volume":"84","author":"Deng","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bone.2007.02.028_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2007.02.028_bib11","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1359\/jbmr.2003.18.11.2043","article-title":"Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK","volume":"18","author":"Koike","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2007.02.028_bib12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/en.134.1.441","article-title":"Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids","volume":"134","author":"Lee","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2007.02.028_bib13","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1210\/en.137.11.5109","article-title":"Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development","volume":"137","author":"Lee","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2007.02.028_bib14","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1242\/dev.125.24.4977","article-title":"Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3","volume":"125","author":"Naski","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bone.2007.02.028_bib15","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2007.02.028_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s007740200011","article-title":"Human PTH (1\u201334) induces longitudinal bone growth in rats","volume":"20","author":"Ogawa","year":"2002","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2007.02.028_bib17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/371252a0","article-title":"Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia","volume":"371","author":"Rousseau","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bone.2007.02.028_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1651-2227.1999.tb14369.x","article-title":"Molecular defects in achondroplasia and the effects of growth hormone treatment","volume":"88","author":"Seino","year":"1999","journal-title":"Acta Paediatr. Suppl."},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2007.02.028_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000023534","article-title":"Growth hormone therapy in achondroplasia","volume":"53","author":"Seino","year":"2000","journal-title":"Horm. Res."},{"key":"10.1016\/j.bone.2007.02.028_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","article-title":"Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia","volume":"78","author":"Shiang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bone.2007.02.028_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/eje.0.1380275","article-title":"Effect of growth hormone therapy in children with achondroplasia: growth pattern, hypothalamic\u2013pituitary function, and genotype","volume":"138","author":"Tanaka","year":"1998","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bone.2007.02.028_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1086\/302275","article-title":"A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene","volume":"64","author":"Tavormina","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib23","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/hmg\/4.11.2175","article-title":"Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I","volume":"4","author":"Tavormina","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0395-321","article-title":"Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3","volume":"9","author":"Tavormina","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2007.02.028_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1210\/er.21.1.23","article-title":"The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans","volume":"21","author":"Vajo","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bone.2007.02.028_bib26","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.96.8.4455","article-title":"A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3","volume":"96","author":"Wang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2007.02.028_bib27","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/MCB.16.8.4081","article-title":"Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type","volume":"16","author":"Webster","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bone.2007.02.028_bib28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/j.1460-2075.1996.tb00384.x","article-title":"Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia","volume":"15","author":"Webster","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2007.02.028_bib29","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.93.19.10240","article-title":"Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation","volume":"93","author":"Weir","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2007.02.028_bib30","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1359\/jbmr.2003.18.8.1395","article-title":"PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation","volume":"18","author":"Yamanaka","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2007.02.028_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000074503","article-title":"Molecular basis for the treatment of achondroplasia","volume":"60","author":"Yamanaka","year":"2003","journal-title":"Horm. Res."},{"key":"10.1016\/j.bone.2007.02.028_bib32","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.1074\/jbc.273.19.11695","article-title":"Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide\/guanylyl cyclase-B pathway","volume":"273","author":"Yasoda","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328207000609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328207000609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T12:39:04Z","timestamp":1628771944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328207000609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S8756328207000609"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2007.02.028","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}