{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:18Z","timestamp":1761058758591},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.bone.2008.01.001","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T12:35:45Z","timestamp":1200659745000},"page":"702-709","source":"Crossref","is-referenced-by-count":13,"title":["Effects of alendronate and pamidronate on cultured rat metatarsal bones: Failure to prevent dexamethasone-induced growth retardation"],"prefix":"10.1016","volume":"42","author":[{"given":"Terhi J.","family":"Heino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei S.","family":"Chagin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Takigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"S\u00e4vendahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.01.001_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00467-004-1790-8","article-title":"Pamidronate treatment of pediatric fracture patients on chronic steroid therapy","volume":"20","author":"Acott","year":"2005","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.bone.2008.01.001_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0889-8529(05)70348-0","article-title":"Growth suppression by glucocorticoid therapy","volume":"25","author":"Allen","year":"1996","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.bone.2008.01.001_bib3","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1359\/jbmr.2002.17.8.1512","article-title":"The comparative efficacy of drug therapies used for the management of corticosteroid-induced osteoporosis: a meta-regression","volume":"17","author":"Amin","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib4","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/1529-0131(200009)43:9<1960::AID-ANR6>3.0.CO;2-J","article-title":"Efficacy and safety of alendronate for the treatment of osteoporosis in diffuse connective tissue diseases in children: a prospective multicenter study","volume":"43","author":"Bianchi","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bone.2008.01.001_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00005792-199707000-00005","article-title":"Long-term effects of bisphosphonates on the growing skeleton. Studies of young patients with severe osteoporosis","volume":"76","author":"Brumsen","year":"1997","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bone.2008.01.001_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s002230010045","article-title":"A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta","volume":"69","author":"Camacho","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2008.01.001_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.1.06364","article-title":"Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis","volume":"188","author":"Chagin","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bone.2008.01.001_bib8","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.bone.2006.12.066","article-title":"Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones","volume":"40","author":"Chagin","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.01.001_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.0.1760331","article-title":"Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes","volume":"176","author":"Chrysis","year":"2003","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bone.2008.01.001_bib10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1210\/en.2004-1152","article-title":"Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3\u2032-kinase signaling pathway","volume":"146","author":"Chrysis","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.01.001_bib11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1210\/en.142.1.430","article-title":"Regulation of growth plate chondrogenesis by bone morphogenetic protein-2","volume":"142","author":"De Luca","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.01.001_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1359\/JBMR.051006","article-title":"Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with osteogenesis imperfecta","volume":"21","author":"DiMeglio","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S8756-3282(02)00974-2","article-title":"Alendronate affects long bone length and growth plate morphology in the oim mouse model for osteogenesis imperfecta","volume":"32","author":"Evans","year":"2003","journal-title":"Bone"},{"issue":"Suppl 2","key":"10.1016\/j.bone.2008.01.001_bib14","first-page":"989","article-title":"Bisphosphonate therapy for severe osteogenesis imperfecta","volume":"13","author":"Glorieux","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.01.001_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00001813-200203000-00006","article-title":"Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines","volume":"13","author":"Heikkila","year":"2002","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bone.2008.01.001_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2003.08.011","article-title":"Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures","volume":"477","author":"Itoh","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bone.2008.01.001_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1359\/JBMR.051207","article-title":"Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta","volume":"21","author":"Land","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib18","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bone.2006.04.004","article-title":"Vertebral morphometry in children and adolescents with osteogenesis imperfecta: effect of intravenous pamidronate treatment","volume":"39","author":"Land","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.01.001_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jbmr.5650030210","article-title":"Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate","volume":"3","author":"Lowik","year":"1988","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(00)00409-9","article-title":"Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism","volume":"28","author":"Mansfield","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.01.001_bib21","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1359\/JBMR.040805","article-title":"Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones","volume":"19","author":"Martensson","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1203\/00006450-200211000-00010","article-title":"Alendronate treatment for infants with osteogenesis imperfecta: demonstration of efficacy in a mouse model","volume":"52","author":"McCarthy","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.bone.2008.01.001_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000014214","article-title":"Dihydrotestosterone prevents glucocorticoid-negative effects on fetal rat metatarsal bone in vitro","volume":"77","author":"Picherit","year":"2000","journal-title":"Biol Neonate"},{"key":"10.1016\/j.bone.2008.01.001_bib24","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1074\/jbc.M412817200","article-title":"Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation","volume":"280","author":"Plotkin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2008.01.001_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bone.2006.02.060","article-title":"Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts\/osteocytes with novel analogs","volume":"39","author":"Plotkin","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.01.001_bib26","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1172\/JCI6800","article-title":"Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin","volume":"104","author":"Plotkin","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.01.001_bib27","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.bone.2006.11.020","article-title":"Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta","volume":"40","author":"Rauch","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.01.001_bib28","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1210\/jc.2005-2413","article-title":"Pamidronate in children and adolescents with osteogenesis imperfecta: effect of treatment discontinuation","volume":"91","author":"Rauch","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.01.001_bib29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pharmtox.38.1.375","article-title":"Mechanisms of action of bisphosphonates","volume":"38","author":"Rodan","year":"1998","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bone.2008.01.001_bib30","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.2174\/1381612033453640","article-title":"New insights into the molecular mechanisms of action of bisphosphonates","volume":"9","author":"Rogers","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bone.2008.01.001_bib31","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/rheumatology\/keh538","article-title":"Effects of once-weekly oral alendronate on bone in children on glucocorticoid treatment","volume":"44","author":"Rudge","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2008.01.001_bib32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1196\/annals.1346.041","article-title":"Bisphosphonates: from bench to bedside","volume":"1068","author":"Russell","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bone.2008.01.001_bib33","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/01.bpo.0000176162.78980.ed","article-title":"Impact of alendronate on quality of life in children with osteogenesis imperfecta","volume":"25","author":"Seikaly","year":"2005","journal-title":"J Pediatr Orthop"},{"key":"10.1016\/j.bone.2008.01.001_bib34","first-page":"3996","article-title":"Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes","volume":"49","author":"Takigawa","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.bone.2008.01.001_bib35","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1359\/jbmr.1999.14.5.784","article-title":"The effects of nitrogen-containing bisphosphonates on human epithelial (Caco-2) cells, an in vitro model for intestinal epithelium","volume":"14","author":"Twiss","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.01.001_bib36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1515\/jpem-2006-190410","article-title":"Efficacy and safety of oral alendronate treatment in children and adolescents with osteoporosis","volume":"19","author":"Unal","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.01.001_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/BTER:104:2:131","article-title":"Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations","volume":"104","author":"Vaisman","year":"2005","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.bone.2008.01.001_bib38","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/ard.61.10.925","article-title":"Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes","volume":"61","author":"Van Offel","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bone.2008.01.001_bib39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00467-006-0306-0","article-title":"Sustained beneficial effect of intravenous bisphosphonates after their discontinuation in children","volume":"22","author":"Waterhouse","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.bone.2008.01.001_bib40","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/jm020819i","article-title":"Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa)","volume":"45","author":"Widler","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bone.2008.01.001_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1191\/1078155205jp145oa","article-title":"Alendronate for steroid-induced osteopenia in children with acute lymphoblastic leukaemia or non-Hodgkin's lymphoma: results of a pilot study","volume":"11","author":"Wiernikowski","year":"2005","journal-title":"J Oncol Pharm Pract"},{"key":"10.1016\/j.bone.2008.01.001_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1096\/fj.03-0294fje","article-title":"Effects of Ca2+ sensing receptor activation in the growth plate","volume":"18","author":"Wu","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.bone.2008.01.001_bib43","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1542\/peds.111.5.1030","article-title":"Height and weight development during four years of therapy with cyclical intravenous pamidronate in children and adolescents with osteogenesis imperfecta types I, III, and IV","volume":"111","author":"Zeitlin","year":"2003","journal-title":"Pediatrics"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208000112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208000112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:56:08Z","timestamp":1708512968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328208000112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S8756328208000112"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.01.001","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}