{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:24:22Z","timestamp":1791138262380,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.bone.2008.03.024","type":"journal-article","created":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T11:13:05Z","timestamp":1208171585000},"page":"264-273","source":"Crossref","is-referenced-by-count":31,"title":["Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice"],"prefix":"10.1016","volume":"43","author":[{"given":"Luciene","family":"Machado do Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Jorgetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Delany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.03.024_bib1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0955-0674(02)00361-7","article-title":"Matricellular proteins: extracellular modulators of cell function","volume":"14","author":"Bornstein","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.bone.2008.03.024_bib2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bone.2005.11.017","article-title":"Matricellular proteins: extracellular modulators of bone development, remodeling, and regeneration","volume":"38","author":"Alford","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.03.024_bib3","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"38","article-title":"Extracellular matrix and biomineraliztion of bone","author":"Robey","year":"2003"},{"key":"10.1016\/j.bone.2008.03.024_bib4","doi-asserted-by":"crossref","first-page":"36483","DOI":"10.1074\/jbc.M504663200","article-title":"SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase","volume":"280","author":"Barker","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2008.03.024_bib5","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1210\/en.2006-0443","article-title":"Increased notch 1 expression and attenuated stimulatory G protein coupling to adenylyl cyclase in osteonectin-null osteoblasts","volume":"148","author":"Kessler","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib6","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI12939","article-title":"SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury","volume":"107","author":"Bradshaw","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.03.024_bib7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI7039","article-title":"Osteopenia and decreased bone formation in osteonectin-null mice","volume":"105","author":"Delany","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.03.024_bib8","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1359\/jbmr.2003.18.6.1005","article-title":"Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wild type controls","volume":"18","author":"Boskey","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib9","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1073\/pnas.1030790100","article-title":"SPARC-null mice exhibit increased adiposity without significant differences in overall body weight","volume":"100","author":"Bradshaw","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2008.03.024_bib10","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1210\/en.2002-221044","article-title":"Osteonectin-null mutation compromises osteoblast formation, maturation, and survival","volume":"144","author":"Delany","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMra067395","article-title":"Mechanisms of anabolic therapies for osteoporosis","volume":"357","author":"Canalis","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2008.03.024_bib12","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/jbmr.5650100718","article-title":"Extracellular matrix stoichiometry in osteoblasts from patients with osteogenesis imperfecta","volume":"10","author":"Fedarko","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/jbmr.5650070809","article-title":"Extracellular matrix formation by osteoblasts from patients with osteogenesis imperfecta","volume":"7","author":"Fedarko","year":"1992","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib14","unstructured":"Delany AM, McMahon DJ, Powell JS, Greenberg DA, Kurland ES. Osteonectin\/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis and healthy male controls. Osteoporosis Int. in press."},{"key":"10.1016\/j.bone.2008.03.024_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/35067016","article-title":"mRNA localization: message on the move","volume":"4","author":"Jansen","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bone.2008.03.024_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(01)00583-9","article-title":"When the message goes awry: disease-producing mutations that influence mRNA content and performance","volume":"107","author":"Mendell","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bone.2008.03.024_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1210\/en.2004-0766","article-title":"Skeletal overexpression of gremlin impairs bone formation and causes osteopenia","volume":"146","author":"Gazzerro","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1359\/jbmr.070507","article-title":"Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice","volume":"22","author":"Glatt","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1359\/JBMR.041204","article-title":"\u0392-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice","volume":"20","author":"Bouxsein","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib20","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1359\/jbmr.060726","article-title":"T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy","volume":"21","author":"Lee","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib21","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.140.8.3552","article-title":"Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation","volume":"140","author":"Lee","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1359\/JBMR.0301226","article-title":"PTH differentially regulates expression of RANKL and OPG","volume":"19","author":"Huang","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1359\/JBMR.051007","article-title":"Identification of multiple osteoclast precursor populations in murine bone marrow","volume":"21","author":"Jacquin","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1359\/jbmr.071020","article-title":"A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men","volume":"23","author":"Riggs","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib25","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbrc.2004.11.069","article-title":"Parathyroid hormone and parathyroid homrone-related peptide, and their receptors","volume":"328","author":"Gensure","year":"2005","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/j.bone.2008.03.024_bib26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/en.2004-1283","article-title":"G\u03b112\/G\u03b113 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells","volume":"146","author":"Singh","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib27","doi-asserted-by":"crossref","first-page":"E826","DOI":"10.1152\/ajpendo.00422.2004","article-title":"Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss","volume":"288","author":"Wang","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.03.024_bib28","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1210\/me.2002-0049","article-title":"Parathyroid hormone receptor recycling: role of receptor dephosphorylation and \u03b2-arrestin","volume":"16","author":"Chauvin","year":"2002","journal-title":"Mod Endocrinol"},{"key":"10.1016\/j.bone.2008.03.024_bib29","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1210\/en.2004-1282","article-title":"Bone response to intermittent parathyroid hormone is altered in mice null for \u03b2-arrestin2","volume":"146","author":"Ferrari","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.0105-2896.2005.00325.x","article-title":"Role of ITAM-containing adapter proteins and their receptors in the immune system and bone","volume":"208","author":"Humphrey","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bone.2008.03.024_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1083\/jcb.134.3.771","article-title":"Identification of stromal cell products that interact with pre-B cells","volume":"134","author":"Oritani","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bone.2008.03.024_bib32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.gene.6364388","article-title":"Splenic and immune alterations in the Sparc-null mouse accompany a lack of immune response","volume":"8","author":"Rempel","year":"2007","journal-title":"Genes Immun"},{"key":"10.1016\/j.bone.2008.03.024_bib33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1189\/jlb.1105664","article-title":"SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration","volume":"81","author":"Kelly","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.bone.2008.03.024_bib34","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2006-08-041384","article-title":"Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bone.2008.03.024_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(96)01495-0","article-title":"Expression of the cell-adhesion molecule VCAM-1 by stromal cells is necessary for osteoclastogenesis","volume":"402","author":"Feuerbach","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bone.2008.03.024_bib36","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood.V96.5.1953","article-title":"Cell\u2013cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast stimulating activity","volume":"96","author":"Michigami","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bone.2008.03.024_bib37","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1210\/en.2002-220996","article-title":"Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation","volume":"144","author":"Kitahara","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.03.024_bib38","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1073\/pnas.96.14.8156","article-title":"Osteopontin-deficient mice are resistant to ovariectomy-induced bone loss","volume":"96","author":"Yoshitake","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bone.2008.03.024_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1359\/jbmr.2002.17.4.661","article-title":"Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice","volume":"17","author":"Ishijima","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.03.024_bib40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.matbio.2005.05.008","article-title":"Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice","volume":"24","author":"Hankenson","year":"2005","journal-title":"Matrix Biol"},{"key":"10.1016\/j.bone.2008.03.024_bib41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bone.2005.08.027","article-title":"Mice lacking thrombospondin 2 show atypical pattern of endocoritcal loading and periosteal bone formation I response to mechanical loading","volume":"38","author":"Hankenson","year":"2006","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820800183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632820800183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T08:47:49Z","timestamp":1588582069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632820800183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S875632820800183X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.03.024","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}