{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:33:46Z","timestamp":1783485226137,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.bone.2008.05.007","type":"journal-article","created":{"date-parts":[[2008,5,17]],"date-time":"2008-05-17T04:55:30Z","timestamp":1211000130000},"page":"418-426","source":"Crossref","is-referenced-by-count":109,"title":["Critical role of the hypothalamic\u2013pituitary\u2013thyroid axis in bone"],"prefix":"10.1016","volume":"43","author":[{"given":"J.H. Duncan","family":"Bassett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2008.05.007_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","article-title":"TSH is a negative regulator of skeletal remodeling","volume":"115","author":"Abe","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bone.2008.05.007_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1359\/jbmr.070302","article-title":"Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats","volume":"22","author":"Sampath","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.05.007_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/105072503322238854","article-title":"Hyperthyroidism, bone mineral, and fracture risk\u2014a meta-analysis","volume":"13","author":"Vestergaard","year":"2003","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1530\/EJE-07-0247","article-title":"Low TSH levels are not associated with osteoporosis in childhood","volume":"157","author":"Papadimitriou","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/PL00000941","article-title":"The TSH receptor and its role in thyroid disease","volume":"58","author":"Kopp","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.bone.2008.05.007_bib6","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/j.1460-2075.1996.tb00664.x","article-title":"Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function","volume":"15","author":"Forrest","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.bone.2008.05.007_bib7","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1074\/jbc.M511530200","article-title":"Dominant role of thyrotropin-releasing hormone in the hypothalamic\u2013pituitary\u2013thyroid axis","volume":"281","author":"Nikrodhanond","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2008.05.007_bib8","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1172\/JCI26031","article-title":"Thyrotropin receptor-associated diseases: from adenomata to Graves disease","volume":"115","author":"Davies","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.05.007_bib9","doi-asserted-by":"crossref","first-page":"C1056","DOI":"10.1152\/ajpcell.00058.2002","article-title":"TSH signaling and cell survival in 3T3-L1 preadipocytes","volume":"283","author":"Bell","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bone.2008.05.007_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI0216234","article-title":"The TSH receptor reveals itself","volume":"110","author":"Davies","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.05.007_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/08916930310001603019","article-title":"Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid","volume":"36","author":"Klein","year":"2003","journal-title":"Autoimmunity"},{"key":"10.1016\/j.bone.2008.05.007_bib12","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1210\/jcem.85.11.6991","article-title":"Expression of the thyroid-stimulating hormone receptor in the folliculo-stellate cells of the human anterior pituitary","volume":"85","author":"Prummel","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.05.007_bib13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/mend.14.5.0458","article-title":"Involvement of JAK\/STAT (Janus kinase\/signal transducer and activator of transcription) in the thyrotropin signaling pathway","volume":"14","author":"Park","year":"2000","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib14","first-page":"596","article-title":"The thyrotropin receptor and the regulation of thyrocyte function and growth","volume":"13","author":"Vassart","year":"1992","journal-title":"Endocr Rev"},{"key":"10.1016\/j.bone.2008.05.007_bib15","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1172\/JCI30380","article-title":"Thyrocyte-specific Gq\/G11 deficiency impairs thyroid function and prevents goiter development","volume":"117","author":"Kero","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.05.007_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1073\/pnas.93.1.116","article-title":"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families","volume":"93","author":"Laugwitz","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2008.05.007_bib17","doi-asserted-by":"crossref","first-page":"36601","DOI":"10.1074\/jbc.M406232200","article-title":"A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor","volume":"279","author":"Cleator","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bone.2008.05.007_bib18","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1210\/en.2006-0390","article-title":"Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice","volume":"147","author":"Dumitrescu","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib19","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1210\/me.2005-0256","article-title":"Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism","volume":"20","author":"Friesema","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/thy.2005.15.757","article-title":"Thyroid hormone transporters in health and disease","volume":"15","author":"Jansen","year":"2005","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib21","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1172\/JCI29812","article-title":"Deiodinases: implications of the local control of thyroid hormone action","volume":"116","author":"Bianco","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.05.007_bib22","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","article-title":"Physiological and molecular basis of thyroid hormone action","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bone.2008.05.007_bib23","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/BF01955262","article-title":"Catch-up growth after prolonged hypothyroidism","volume":"155","author":"Boersma","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.bone.2008.05.007_bib24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJM198803103181003","article-title":"Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature","volume":"318","author":"Rivkees","year":"1988","journal-title":"N Engl J Med"},{"issue":"Suppl 5","key":"10.1016\/j.bone.2008.05.007_bib25","first-page":"1277","article-title":"The aftermath of childhood hyperthyroidism","volume":"14","author":"Segni","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.05.007_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2265.2004.02053.x","article-title":"The thyroid and the skeleton","volume":"61","author":"Murphy","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bone.2008.05.007_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","article-title":"Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group","volume":"332","author":"Cummings","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2008.05.007_bib28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1056\/NEJM199803123381103","article-title":"Mortality after the treatment of hyperthyroidism with radioactive iodine","volume":"338","author":"Franklyn","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2008.05.007_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/thy.2000.10.341","article-title":"Fracture risk in patients treated for hyperthyroidism","volume":"10","author":"Vestergaard","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/105072502760043503","article-title":"Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients","volume":"12","author":"Vestergaard","year":"2002","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0889-8529(18)30338-4","article-title":"Effects of thyroid hormones on bone and mineral metabolism","volume":"19","author":"Mosekilde","year":"1990","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.bone.2008.05.007_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/thy.2006.16.583","article-title":"The effects of thyrotropin-suppressive therapy on bone metabolism in patients with well-differentiated thyroid carcinoma","volume":"16","author":"Heemstra","year":"2006","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jso.10043","article-title":"Bone mineral density in well-differentiated thyroid cancer patients treated with suppressive thyroxine: a systematic overview of the literature","volume":"79","author":"Quan","year":"2002","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.bone.2008.05.007_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-134-7-200104030-00009","article-title":"Risk for fracture in women with low serum levels of thyroid-stimulating hormone","volume":"134","author":"Bauer","year":"2001","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.bone.2008.05.007_bib35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2265.2005.02422.x","article-title":"Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women","volume":"64","author":"Kim","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bone.2008.05.007_bib36","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bone.2006.12.001","article-title":"The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women","volume":"40","author":"Morris","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.05.007_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2265.2007.03016.x","article-title":"Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study","volume":"68","author":"van der Deure","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bone.2008.05.007_bib38","first-page":"401","article-title":"Treatment of resistance to thyroid hormone\u2014primum non nocere","volume":"84","author":"Weiss","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bone.2008.05.007_bib39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0889-8529(05)70349-2","article-title":"Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone","volume":"25","author":"Weiss","year":"1996","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.bone.2008.05.007_bib40","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJM199712043372307","article-title":"The thyrotropin receptor in thyroid diseases","volume":"337","author":"Paschke","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bone.2008.05.007_bib41","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1359\/JBMR.041126","article-title":"Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma","volume":"20","author":"Mazziotti","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bone.2008.05.007_bib42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.14310\/horm.2002.1111026","article-title":"Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappaBeta ligand in patients under evaluation for differentiated thyroid carcinoma","volume":"6","author":"Giusti","year":"2007","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.bone.2008.05.007_bib43","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1210\/me.2007-0033","article-title":"Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism","volume":"21","author":"Bassett","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib44","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/me.2007-0157","article-title":"Thyroid status during skeletal development determines adult bone structure and mineralization","volume":"21","author":"Bassett","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib45","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1210\/me.2005-0224","article-title":"Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta","volume":"19","author":"O'Shea","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib46","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1210\/me.2002-0296","article-title":"A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone","volume":"17","author":"O'Shea","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib47","doi-asserted-by":"crossref","first-page":"e011","DOI":"10.1621\/nrs.04011","article-title":"Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression","volume":"4","author":"O'Shea","year":"2006","journal-title":"Nucl Recept Signal"},{"key":"10.1016\/j.bone.2008.05.007_bib48","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1210\/en.2005-0762","article-title":"Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis","volume":"146","author":"Barnard","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib49","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","article-title":"Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network","volume":"126","author":"Bookout","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bone.2008.05.007_bib50","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1101\/gad.13.10.1329","article-title":"Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary\u2013thyroid axis, growth, and bone maturation","volume":"13","author":"Gothe","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.bone.2008.05.007_bib51","doi-asserted-by":"crossref","first-page":"15776","DOI":"10.1073\/pnas.242322099","article-title":"Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice","volume":"99","author":"Marians","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2008.05.007_bib52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/en.2002-220715","article-title":"Regulation of iodothyronine deiodinases in the Pax8\u2212\/\u2212 mouse model of congenital hypothyroidism","volume":"144","author":"Friedrichsen","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib53","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1210\/me.2007-0221","article-title":"A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism","volume":"22","author":"Bassett","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bone.2008.05.007_bib54","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/en.2007-0993","article-title":"Catch-up growth after hypothyroidism is caused by delayed growth plate senescence","volume":"149","author":"Marino","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib55","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/endo.141.12.7839","article-title":"Expression of cyclin-dependent kinase inhibitors in epiphyseal chondrocytes induced to terminally differentiate with thyroid hormone","volume":"141","author":"Ballock","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/endo.134.1.8275930","article-title":"Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption","volume":"134","author":"Britto","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/8756-3282(95)00102-J","article-title":"Tri-iodothyronine (T3) and dexamethasone interact to modulate osteoprogenitor cell differentiation in fetal rat calvaria cell cultures","volume":"16","author":"Ishida","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.bone.2008.05.007_bib58","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1210\/endo.139.5.5992","article-title":"Thyroid hormone excess increases insulin-like growth factor I transcripts in bone marrow cell cultures: divergent effects on vertebral and femoral cell cultures","volume":"139","author":"Milne","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib59","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI108497","article-title":"Direct stimulation of bone resorption by thyroid hormones","volume":"58","author":"Mundy","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bone.2008.05.007_bib60","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/jcp.1041610318","article-title":"Thyroid hormone suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances functional activities of mature osteoblasts in cultured rat calvaria cells","volume":"161","author":"Ohishi","year":"1994","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bone.2008.05.007_bib61","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1210\/endo.141.10.7733","article-title":"Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation","volume":"141","author":"Robson","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2008.05.007_bib62","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/thy.1998.8.1059","article-title":"Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells","volume":"8","author":"Inoue","year":"1998","journal-title":"Thyroid"},{"key":"10.1016\/j.bone.2008.05.007_bib63","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1073\/pnas.0600427103","article-title":"TNFalpha mediates the skeletal effects of thyroid-stimulating hormone","volume":"103","author":"Hase","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2008.05.007_bib64","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1073\/pnas.0712395105","article-title":"Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss","volume":"105","author":"Sun","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bone.2008.05.007_bib65","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF02554999","article-title":"Calcitonin and bone mass status in congenital hypothyroidism","volume":"46","author":"Demeester-Mirkine","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bone.2008.05.007_bib66","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1530\/eje.0.1510689","article-title":"Effect of long-term L-thyroxine treatment on bone mineral density in young adults with congenital hypothyroidism","volume":"151","author":"Salerno","year":"2004","journal-title":"Eur J Endocrinol"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208002421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328208002421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T07:26:33Z","timestamp":1708932393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328208002421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S8756328208002421"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2008.05.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1124537.581743","asserted-by":"object"}]},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}